ID you entered:  ENSP00000014112

Ensembl protein: ENSP00000014112   

          Protein sequence 
Name: PTBP1
Description: polypyrimidine tract binding protein 1 [Source:HGNC Symbol;Acc:HGNC:9583]
Location:
            chr19 p13.3
Gene Ontology:
           Biological process 
           Molecular function 
           Cellular localization 
Interactions:   
          Interaction partner with cancer_related variations :  (  pvalue=0.145809, hypergeometric test )
                 25 
          Interaction partner with cancer related differentially expressed proteins :  (  pvalue=0.0196533, hypergeometric test )
                 12 
                         

  • Cancer-related variations in CanProVar:
    • NO.csIDvariationchange conservation+Domaincancer namePubMeddata source++validated dbSNP*interface
    1cs18875*532R-4Breast Cancer20668451   COSMIC

    +Conservation of amino acid substitutions are defined here according to the BLOSUM62 matrix, conservative changes were those having a positive or neutral sign in the matrix, whereas non-conservative changes were those having a negative value (Cargill, et al. 1999).
    ++Data sources:  HPI,  COSMIC,  OMIM,  TCGA,  BIOMART,  Greenman2007,  Sjoblom2006,  Ding2008
    *Cross-reference databases: dbSNP
    Interface information was collected from Wang 2012


  • Non-cancer specific variations derived from database dbSNP:

    • NO.dbSNP_IDvariationvalidated
    1rs140010693S16F1000Genome
    2rs202040078F29L1000Genome
    3rs140945539A54T1000Genome
    4rs11549885R64WHapMap
    5rs11549886S116LHapMap
    6rs150661031A173TFrequency
    7rs144400768A176V1000Genome
    8rs189076650H201Q1000Genome
    9rs201221864A229VCluster
    10rs147259741S288LCluster,Frequency,1000Genome
    11rs189842365A312T1000Genome
    12rs146498992V481IFrequency


  • Cancer-related differential expression proteins derived from database dbDEPC:

    • NO.dbDEPC_IDchangeratiocancer namedesignsample_controlsample_casesamplepubmed
    1EXP00024Uterine CancerNormal vs. CancerNegative for Intraepithelial Lesions or Malignancy (NILM)High-Grade Squamous Intraepithelial Lesion(HSIL) tissue17902640  
    2EXP00070Breast CancerTreatment (Antiestrogen-sensitive vs. Antiestrogen-resistant)human breast carcinoma cell line T47DAntiestrogen-resistant Derivative T47D-rcell line14557597  
    3EXP00284Testicular CancerNormal vs. CancerHuman embryonic stem cells (hESC) line HUES-7 Human embryonal carcinoma cells (hECCs) line NT2/D1cell line18489135  
    4EXP001760.4Non-small cell lung carcinomaTreatment (none vs CIGB-300 treatment)The non-small cell lung cancer(NSCLC) cell line NCI-H125NCI-H125 cell line incubated with 200 ??mol/L of CIGB-300 during 45 mincell line20804217  



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