CanProVar is designed to store and display single amino acid alterations including both germline and somatic variations in the human proteome, especially those related to the genesis or development of human cancer based on the published literatures and sources . Cancer-related variations and their comprehensive annotations can be queried through the web-interface using not only protein names/ IDs, cancer type, but also protein list, chromosome location or pathway, in which user is interested.

Furthermore, the FASTA sequence of proteins and their variation information can be downloaded as well as the searchable mutant peptides for shotgun proteomics.