ID you entered:  ENSP00000215591

Ensembl protein: ENSP00000215591   

          Protein sequence 
Name: POLRMT
Description: polymerase (RNA) mitochondrial (DNA directed) [Source:HGNC Symbol;Acc:9200]
Location:
            chr19 p13.3
Gene Ontology:
           Biological process 
           Molecular function 
           Cellular localization 
Interactions:   
          Interaction partner with cancer_related variations :  (  pvalue=0.278331, hypergeometric test )
                 6 
          Interaction partner with cancer related differentially expressed proteins :  (  pvalue=0.286972, hypergeometric test )
                 2 
                         

  • Cancer-related variations in CanProVar:
    • NO.csIDvariationchange conservation+Domaincancer namePubMeddata source++validated dbSNP*interface
    1cs34678E826Q2Ovarian Cancer20826764   COSMIC

    +Conservation of amino acid substitutions are defined here according to the BLOSUM62 matrix, conservative changes were those having a positive or neutral sign in the matrix, whereas non-conservative changes were those having a negative value (Cargill, et al. 1999).
    ++Data sources:  HPI,  COSMIC,  OMIM,  TCGA,  BIOMART,  Greenman2007,  Sjoblom2006,  Ding2008
    *Cross-reference databases: dbSNP
    Interface information was collected from Wang 2012


  • Non-cancer specific variations derived from database dbSNP:

    • NO.dbSNP_IDvariationvalidated
    1rs12610885P38SCluster,Frequency,1000Genome,HapMap
    2rs150947088Q47HCluster,Frequency
    3rs139758373V60MCluster,Frequency,1000Genome
    4rs140649984V78MFrequency
    5rs189184481S96N1000Genome
    6rs77466198M109I1000Genome
    7rs113148837R131QCluster,Frequency,1000Genome
    8rs150838232F148LFrequency
    9rs149933500R159CCluster,Frequency,1000Genome
    10rs146345748C174F1000Genome
    11rs182390676P210L1000Genome
    12rs145312875R253WCluster,1000Genome
    13rs140683573R256QFrequency
    14rs115263594I316VFrequency
    15rs138732981Q322LCluster,Frequency,1000Genome
    16rs143022703M323ICluster,Frequency,1000Genome
    17rs41553913F400LCluster,Frequency,1000Genome
    18rs144770419A409VFrequency
    19rs142443929V417MFrequency
    20rs148655029A444VFrequency
    21rs144179084R447QFrequency
    22rs146178977R481PFrequency
    23rs141490879M482VFrequency
    24rs115950441E545K1000Genome
    25rs2238549E555AHapMap,1000Genome,Cluster,Frequency
    26rs41545023P566SCluster
    27rs61745193R598HCluster,Frequency,1000Genome
    28rs150982430T656KFrequency
    29rs10421235V713LCluster,1000Genome
    30rs61743194R759HFrequency
    31rs139383492D870NCluster,Frequency,1000Genome
    32rs143734190A912VFrequency
    33rs151235528E947KCluster,Frequency,1000Genome
    34rs147740567R1173CCluster,Frequency,1000Genome
    35rs142850300S1193FCluster,Frequency,1000Genome
    36rs138715064I1198LFrequency
    37rs151287767L1199SFrequency


  • Cancer-related differential expression proteins derived from database dbDEPC:

    • NO.dbDEPC_IDchangeratiocancer namedesignsample_controlsample_casesamplepubmed
    1EXP00284Testicular CancerNormal vs. CancerHuman embryonic stem cells (hESC) line HUES-7 Human embryonal carcinoma cells (hECCs) line NT2/D1cell line18489135  



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