CanProVar 2.0:Human Cancer Proteome Variation Database

ID you entered: ENSP00000221566

Ensembl protein: ENSP00000221566

Protein sequence

Name: SGTA

Description: small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha [Source:HGNC Symbol;Acc:HGNC:10819]

Location:

chr19 p13.3

Gene Ontology:

Biological process

Molecular function

Cellular localization

Interactions:

Interaction partner with cancer_related variations : ( pvalue=0.139778, hypergeometric test )

Interaction partner with cancer related differentially expressed proteins : ( pvalue=0.006476, hypergeometric test )

Cancer-related variations in CanProVar:

NO.	csID	variation	change conservation⁺	Domain	cancer name	PubMed	data source⁺⁺	validated dbSNP*	interface
1	cs25524	E187D	2	PF00515 PF07719	Ovarian Cancer	21720365	COSMIC		SGTA

⁺Conservation of amino acid substitutions are defined here according to the BLOSUM62 matrix, conservative changes were those having a positive or neutral sign in the matrix, whereas non-conservative changes were those having a negative value (Cargill, et al. 1999).
⁺⁺Data sources: HPI, COSMIC, OMIM, TCGA, BIOMART, Greenman2007, Sjoblom2006, Ding2008
*Cross-reference databases: dbSNP
Interface information was collected from Wang 2012

Non-cancer specific variations derived from database dbSNP:

NO.	dbSNP_ID	variation	validated
1	rs147785576	R20Q	Cluster,Frequency
2	rs144833700	G23R	Frequency
3	rs145050792	P82L	Cluster
4	rs200270910	G253V	1000Genome

Cancer-related differential expression proteins derived from database dbDEPC:

NO.	dbDEPC_ID	ratio	cancer name	design	sample_control	sample_case	sample	pubmed
1	EXP00061	0.48	Esophageal Cancer	Normal vs. Cancer	matched normal mucosal tissues from 82 ESCC (esophageal squamous cell carcinoma) patients	primary tumor tissues from 82 ESCC (esophageal squamous cell carcinoma) patients	tissue	19142970
2	EXP00015	1.9	Gastric Cancer	Metastasis	the noninvasive gastric cancer SC-M1 cell	the metastatic gastric cancer TMC-1 cells	cell line	17022644
3	EXP00186	1.9	Gastric Cancer	Metastasis	the noninvasive gastric cancer SC-M1 cell(a well-established human gastric carcinoma cell line, originally cultured from a poorly differentiated adenocarcinoma that invaded through the stomach wall but showed no metastasis to lymph nodes or adjacent organs)	the metastatic gastric cancer TMC-1 cells(derived from the lymph node of an individual with a moderately differentiated adenocarcinoma of the stomach and exhibited highly tumorigenic features)	cell line	17022644

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