ID you entered:  ENSP00000221856

Ensembl protein: ENSP00000221856   

          Protein sequence 
Name: FSD1
Description: fibronectin type III and SPRY domain containing 1 [Source:HGNC Symbol;Acc:HGNC:13745]
Location:
            chr19 p13.3
Gene Ontology:
           Biological process 
           Molecular function 
           Cellular localization 
Interactions:   
          Interaction partner with cancer_related variations :  (  pvalue=0.274799, hypergeometric test )
                 4 
          Interaction partner with cancer related differentially expressed proteins :    NA
                         

  • Cancer-related variations in CanProVar:
    • NO.csIDvariationchange conservation+Domaincancer namePubMeddata source++validated dbSNP*interface
    1cs38131L134F0Breast Cancer21930502  21930507   BIOMART
    2cs40133D179G-1PF00041  Head and Neck Cancer21798893   COSMIC
    3cs65295V246G-3PF00041  Melanoma21499247   COSMIC

    +Conservation of amino acid substitutions are defined here according to the BLOSUM62 matrix, conservative changes were those having a positive or neutral sign in the matrix, whereas non-conservative changes were those having a negative value (Cargill, et al. 1999).
    ++Data sources:  HPI,  COSMIC,  OMIM,  TCGA,  BIOMART,  Greenman2007,  Sjoblom2006,  Ding2008
    *Cross-reference databases: dbSNP
    Interface information was collected from Wang 2012


  • Non-cancer specific variations derived from database dbSNP:

    • NO.dbSNP_IDvariationvalidated
    1rs76548334V17GCluster
    2rs138205709M32ICluster,Frequency
    3rs149694101T88MFrequency
    4rs145281893A127TFrequency
    5rs141559654R153W1000Genome
    6rs45575337P210LCluster,Frequency,1000Genome
    7rs35139245L232VCluster,Frequency,1000Genome
    8rs189542513R271H1000Genome
    9rs150751084G307SFrequency
    10rs111498394K308ECluster
    11rs139108551T311MFrequency
    12rs182090774G353S1000Genome
    13rs148882494E363KFrequency
    14rs200289353R439HCluster


  • Cancer-related differential expression proteins derived from database dbDEPC:


    • No entry in dbDEPC was found



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