CanProVar 2.0:Human Cancer Proteome Variation Database

ID you entered: ENSP00000245816

Ensembl protein: ENSP00000245816

Protein sequence

Name: CLPP

Description: caseinolytic mitochondrial matrix peptidase proteolytic subunit [Source:HGNC Symbol;Acc:HGNC:2084]

Location:

chr19 p13.3

Gene Ontology:

Biological process

Molecular function

Cellular localization

Interactions:

Interaction partner with cancer_related variations : ( pvalue=0.202152, hypergeometric test )

Interaction partner with cancer related differentially expressed proteins : ( pvalue=0.00559039, hypergeometric test )

Cancer-related variations in CanProVar:

NO.	csID	variation	change conservation⁺	Domain	cancer name	PubMed	data source⁺⁺	validated dbSNP*	interface
1	cs29386	R228H	0	PF00574	Ovarian Cancer	18772890 21720365	TCGA, COSMIC

⁺Conservation of amino acid substitutions are defined here according to the BLOSUM62 matrix, conservative changes were those having a positive or neutral sign in the matrix, whereas non-conservative changes were those having a negative value (Cargill, et al. 1999).
⁺⁺Data sources: HPI, COSMIC, OMIM, TCGA, BIOMART, Greenman2007, Sjoblom2006, Ding2008
*Cross-reference databases: dbSNP
Interface information was collected from Wang 2012

Non-cancer specific variations derived from database dbSNP:

NO.	dbSNP_ID	variation	validated
1	rs76439648	Q187K	Cluster
2	rs112719208	V264A	Frequency

Cancer-related differential expression proteins derived from database dbDEPC:

NO.	dbDEPC_ID	change	ratio	cancer name	design	sample_control	sample_case	sample	pubmed
1	EXP00336		0.3	Pancreatic Cancer	Normal vs. Cancer	pooled pancreatic juices from 10 normal controls	pancreatic cancerous juice	tissue	16739137

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