ID you entered:  ENSP00000245908

Ensembl protein: ENSP00000245908   

          Protein sequence 
Name: SH2D3A
Description: SH2 domain containing 3A [Source:HGNC Symbol;Acc:HGNC:16885]
Location:
            chr19 p13.3
Gene Ontology:
           Biological process 
           Molecular function 
           Cellular localization 
Interactions:   
          Interaction partner with cancer_related variations :  (  pvalue=0.104267, hypergeometric test )
                 7 
          Interaction partner with cancer related differentially expressed proteins :    NA
                         

  • Cancer-related variations in CanProVar:
    • NO.csIDvariationchange conservation+Domaincancer namePubMeddata source++validated dbSNP*interface
    1cs52799S225F-2Skin Cancer21984974   COSMIC
    2cs1801E265G-2Breast Cancer18428421  16959974   HPI, COSMIC, Sjoblom2006
    3cs88588R436*-4PF00617  Skin Cancer21984974   COSMIC

    +Conservation of amino acid substitutions are defined here according to the BLOSUM62 matrix, conservative changes were those having a positive or neutral sign in the matrix, whereas non-conservative changes were those having a negative value (Cargill, et al. 1999).
    ++Data sources:  HPI,  COSMIC,  OMIM,  TCGA,  BIOMART,  Greenman2007,  Sjoblom2006,  Ding2008
    *Cross-reference databases: dbSNP
    Interface information was collected from Wang 2012


  • Non-cancer specific variations derived from database dbSNP:

    • NO.dbSNP_IDvariationvalidated
    1rs7258236N32DCluster,Frequency,1000Genome
    2rs7254471A39TCluster,Frequency,1000Genome
    3rs185333277R68H1000Genome
    4rs76024146Y95CCluster,1000Genome
    5rs149620409R121*Cluster,1000Genome
    6rs150449347I136TFrequency
    7rs142658713R142TCluster,Frequency,1000Genome
    8rs147966200M155TFrequency
    9rs148876828R157WCluster,Frequency,1000Genome
    10rs62125124R157QCluster,Frequency,1000Genome
    11rs76568513S173TCluster,Frequency,1000Genome
    12rs199768523R177QCluster
    13rs145013085D196NCluster,Frequency
    14rs144111577D196GCluster,1000Genome
    15rs139285655R199GFrequency
    16rs148100115S201FCluster,Frequency,1000Genome
    17rs187868330D202N1000Genome
    18rs141846132L205FFrequency
    19rs76213282A209TCluster,Frequency,1000Genome
    20rs139813452R215QFrequency
    21rs12608960D223GCluster,Frequency,1000Genome,HapMap
    22rs143491346P229LFrequency
    23rs10404295V235MCluster,Frequency
    24rs142596297Q248*Cluster
    25rs191413930E266K1000Genome
    26rs140434613R295QCluster
    27rs151282649S316NCluster,Frequency,1000Genome
    28rs180742911V396I1000Genome
    29rs146711285R427GFrequency
    30rs143503063P452SFrequency
    31rs184596900H502Y1000Genome
    32rs61729851A555V1000Genome


  • Cancer-related differential expression proteins derived from database dbDEPC:


    • No entry in dbDEPC was found



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