ID you entered:  ENSP00000246115

Ensembl protein: ENSP00000246115   

          Protein sequence 
Name: S1PR4
Description: sphingosine-1-phosphate receptor 4 [Source:HGNC Symbol;Acc:HGNC:3170]
Location:
            chr19 p13.3
Gene Ontology:
           Biological process 
           Molecular function 
           Cellular localization 
Interactions:   
          Interaction partner with cancer_related variations :  (  pvalue=0.239535, hypergeometric test )
                 2 
          Interaction partner with cancer related differentially expressed proteins :    NA
                         

  • Cancer-related variations in CanProVar:
    • NO.csIDvariationchange conservation+Domaincancer namePubMeddata source++validated dbSNP*interface
    1cs13452Y163C-2PF00001  Lung Cancer20668451   COSMIC
    2cs17031V215I3PF00001  Melanoma21499247   COSMIC
    3cs33001S308F-2Head and Neck Cancer21798893   COSMIC
    4cs25056S379C-1Head and Neck Cancer21798893   COSMIC

    +Conservation of amino acid substitutions are defined here according to the BLOSUM62 matrix, conservative changes were those having a positive or neutral sign in the matrix, whereas non-conservative changes were those having a negative value (Cargill, et al. 1999).
    ++Data sources:  HPI,  COSMIC,  OMIM,  TCGA,  BIOMART,  Greenman2007,  Sjoblom2006,  Ding2008
    *Cross-reference databases: dbSNP
    Interface information was collected from Wang 2012


  • Non-cancer specific variations derived from database dbSNP:

    • NO.dbSNP_IDvariationvalidated
    1rs192182269G45S1000Genome
    2rs183974832R143H1000Genome
    3rs142173388E153KFrequency
    4rs150230356G164SFrequency
    5rs147876709A174TFrequency
    6rs3826936A189SCluster,1000Genome
    7rs3826936A189TCluster,1000Genome
    8rs148909695R192H1000Genome
    9rs143964699A213TCluster,Frequency,1000Genome
    10rs61731111R243CCluster,Frequency,1000Genome
    11rs200375168R247CCluster
    12rs184404641R287Q1000Genome
    13rs145561195V318MFrequency
    14rs141031634R362H1000Genome
    15rs3746072R365LCluster,Frequency,1000Genome
    16rs201301306R372W1000Genome
    17rs200756648S376C1000Genome


  • Cancer-related differential expression proteins derived from database dbDEPC:


    • No entry in dbDEPC was found



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