ID you entered:  ENSP00000246117

Ensembl protein: ENSP00000246117   

          Protein sequence 
Name: NCLN
Description: nicalin [Source:HGNC Symbol;Acc:HGNC:26923]
Location:
            chr19 p13.3
Gene Ontology:
           Biological process 
           Molecular function 
           Cellular localization 
Interactions:   
          Interaction partner with cancer_related variations :  (  pvalue=0.289088, hypergeometric test )
                 3 
          Interaction partner with cancer related differentially expressed proteins :    NA
                         

  • Cancer-related variations in CanProVar:
    • NO.csIDvariationchange conservation+Domaincancer namePubMeddata source++validated dbSNP*interface
    1cs49021Q121K1Skin Cancer21984974   COSMIC

    +Conservation of amino acid substitutions are defined here according to the BLOSUM62 matrix, conservative changes were those having a positive or neutral sign in the matrix, whereas non-conservative changes were those having a negative value (Cargill, et al. 1999).
    ++Data sources:  HPI,  COSMIC,  OMIM,  TCGA,  BIOMART,  Greenman2007,  Sjoblom2006,  Ding2008
    *Cross-reference databases: dbSNP
    Interface information was collected from Wang 2012


  • Non-cancer specific variations derived from database dbSNP:

    • NO.dbSNP_IDvariationvalidated
    1rs117922207V141I1000Genome
    2rs75377748K157QCluster,1000Genome
    3rs11671067E214DCluster,Frequency,1000Genome,HapMap
    4rs201906521R316QCluster
    5rs149150446G394SCluster
    6rs182602270S477G1000Genome
    7rs201065233D489ECluster,1000Genome
    8rs200188235V490M1000Genome
    9rs138437194H494RFrequency
    10rs2288949K551RCluster,Frequency,1000Genome,HapMap
    11rs144584009V558LFrequency


  • Cancer-related differential expression proteins derived from database dbDEPC:


    • No entry in dbDEPC was found



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