CanProVar 2.0:Human Cancer Proteome Variation Database

ID you entered: ENSP00000262947

Ensembl protein: ENSP00000262947

Protein sequence

Name: C19orf10

Description: chromosome 19 open reading frame 10 [Source:HGNC Symbol;Acc:HGNC:16948]

Location:

chr19 p13.3

Gene Ontology:

Biological process

Molecular function

Cellular localization

Interactions:

Interaction partner with cancer_related variations : ( pvalue=0.329512, hypergeometric test )

Interaction partner with cancer related differentially expressed proteins : ( pvalue=0.0933677, hypergeometric test )

Cancer-related variations in CanProVar:

NO.	csID	variation	change conservation⁺	Domain	cancer name	PubMed	data source⁺⁺	validated dbSNP*	interface
1	cs68479	*174R	-4		Skin Cancer	21984974	COSMIC

⁺Conservation of amino acid substitutions are defined here according to the BLOSUM62 matrix, conservative changes were those having a positive or neutral sign in the matrix, whereas non-conservative changes were those having a negative value (Cargill, et al. 1999).
⁺⁺Data sources: HPI, COSMIC, OMIM, TCGA, BIOMART, Greenman2007, Sjoblom2006, Ding2008
*Cross-reference databases: dbSNP
Interface information was collected from Wang 2012

Non-cancer specific variations derived from database dbSNP:

NO.	dbSNP_ID	variation	validated
1	rs2270090	G12R	Cluster,Frequency,1000Genome
2	rs151144686	T36R	Frequency
3	rs181353637	H53Q	1000Genome
4	rs190764117	D86N	1000Genome
5	rs145965245	D86A	Frequency
6	rs199958063	F128I	Cluster
7	rs201436134	G153E	Cluster
8	rs143824265	S169L	Cluster,Frequency

Cancer-related differential expression proteins derived from database dbDEPC:

NO.	dbDEPC_ID	change	ratio	cancer name	design	sample_control	sample_case	sample	pubmed
1	EXP00197			Gastric Cancer	Cancer vs. Cancer (good vs. proo survival)	Eight gastric cancer patients with relatively early TNM stage and survival time >34 months were identified as good survival (group G)	the other eight with late stage and survival time <15 months as poor survival (group P)	tissue	18830628
2	EXP00244		3.2	Oral Cancer	Normal vs. Cancer	oral leukoplakia control tissues	OSCC tumor tissues	tissue	19691830

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