ID you entered:  ENSP00000262968

Ensembl protein: ENSP00000262968   

          Protein sequence 
Name: TJP3
Description: tight junction protein 3 (zona occludens 3) [Source:HGNC Symbol;Acc:11829]
Location:
            chr19 p13.3
Gene Ontology:
           Biological process 
           Molecular function 
           Cellular localization 
Interactions:   
          Interaction partner with cancer_related variations :  (  pvalue=0.104267, hypergeometric test )
                 7 
          Interaction partner with cancer related differentially expressed proteins :    NA
                         

  • Cancer-related variations in CanProVar:
    • NO.csIDvariationchange conservation+Domaincancer namePubMeddata source++validated dbSNP*interface
    1cs82977A587V0Central Nervous System Neoplasms18772396   COSMIC
    2cs63670E647K1Head and Neck Cancer21798893   COSMIC

    +Conservation of amino acid substitutions are defined here according to the BLOSUM62 matrix, conservative changes were those having a positive or neutral sign in the matrix, whereas non-conservative changes were those having a negative value (Cargill, et al. 1999).
    ++Data sources:  HPI,  COSMIC,  OMIM,  TCGA,  BIOMART,  Greenman2007,  Sjoblom2006,  Ding2008
    *Cross-reference databases: dbSNP
    Interface information was collected from Wang 2012


  • Non-cancer specific variations derived from database dbSNP:

    • NO.dbSNP_IDvariationvalidated
    1rs147886229L14PFrequency
    2rs138247981A31TCluster,Frequency,1000Genome
    3rs2067019R38HHapMap,1000Genome,Cluster,Frequency
    4rs34029995G47RCluster
    5rs148558078R49QCluster,Frequency,1000Genome
    6rs140801428A91TFrequency
    7rs147974910V143G1000Genome
    8rs192340711D144H1000Genome
    9rs150904142R164C1000Genome
    10rs138301512L195MCluster,Frequency,1000Genome
    11rs149642887V207M1000Genome
    12rs137857763R248CCluster,Frequency,1000Genome
    13rs140861719R248HCluster,Frequency,1000Genome
    14rs141380658R274*Frequency
    15rs192628262I276T1000Genome
    16rs139712661R291HFrequency
    17rs34246692P299RCluster,Frequency,1000Genome
    18rs139837206S303CFrequency
    19rs184889448P324T1000Genome
    20rs140665995R366WFrequency
    21rs186577742P389S1000Genome
    22rs150084019D395NFrequency
    23rs138412311R418HCluster,Frequency,1000Genome
    24rs147011106G426RFrequency
    25rs2302306V435MCluster,Frequency,1000Genome
    26rs138076745S440FFrequency
    27rs150612107E486KFrequency
    28rs61729585T492MCluster,Frequency,1000Genome
    29rs181931412D533N1000Genome
    30rs35628485R569WCluster,Frequency,1000Genome
    31rs138611755R609WFrequency
    32rs146122641E641QFrequency
    33rs182665341V644M1000Genome
    34rs190555817R652H1000Genome
    35rs150181963R652CCluster,Frequency,1000Genome
    36rs148817261H706QCluster,Frequency,1000Genome
    37rs115816600E734KCluster,Frequency,1000Genome
    38rs34479626R751GCluster,Frequency
    39rs142067032R752HFrequency
    40rs138265239T798MFrequency
    41rs144396449R799QFrequency
    42rs35335659R799WCluster,Frequency,1000Genome
    43rs10408494G847DCluster,Frequency,1000Genome
    44rs150992573A848VFrequency
    45rs145696916E853KFrequency
    46rs149440570P871LFrequency
    47rs145549896L875V1000Genome
    48rs182553957R893C1000Genome
    49rs80268715M918TCluster,Frequency,1000Genome
    50rs1046268M931TCluster,Frequency,1000Genome


  • Cancer-related differential expression proteins derived from database dbDEPC:


    • No entry in dbDEPC was found



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