ID you entered:  ENSP00000262971

Ensembl protein: ENSP00000262971   

          Protein sequence 
Name: PIAS4
Description: protein inhibitor of activated STAT, 4 [Source:HGNC Symbol;Acc:HGNC:17002]
Location:
            chr19 p13.3
Gene Ontology:
           Biological process 
           Molecular function 
           Cellular localization 
Interactions:   
          Interaction partner with cancer_related variations :  (  pvalue=0.00204686, hypergeometric test )
                 71 
          Interaction partner with cancer related differentially expressed proteins :    NA
                         

  • Cancer-related variations in CanProVar:
    • NO.csIDvariationchange conservation+Domaincancer namePubMeddata source++validated dbSNP*interface
    1cs10441E157*-4Pancreatic Cancer COSMIC
    2cs25108G381R-2Skin Cancer21984974   COSMIC

    +Conservation of amino acid substitutions are defined here according to the BLOSUM62 matrix, conservative changes were those having a positive or neutral sign in the matrix, whereas non-conservative changes were those having a negative value (Cargill, et al. 1999).
    ++Data sources:  HPI,  COSMIC,  OMIM,  TCGA,  BIOMART,  Greenman2007,  Sjoblom2006,  Ding2008
    *Cross-reference databases: dbSNP
    Interface information was collected from Wang 2012


  • Non-cancer specific variations derived from database dbSNP:

    • NO.dbSNP_IDvariationvalidated
    1rs142623244P77LFrequency
    2rs2289867P100QCluster,Frequency
    3rs148740518K128MCluster,Frequency,1000Genome
    4rs150447524M141T1000Genome
    5rs141113403V223IFrequency
    6rs200365509A254TCluster
    7rs7255988C342WCluster,Frequency,1000Genome
    8rs182911350M364V1000Genome
    9rs139150317P373SFrequency
    10rs145338811R413HCluster,Frequency
    11rs112334040N430SCluster,Frequency,1000Genome
    12rs151289664P434LFrequency
    13rs189209303G440R1000Genome
    14rs76518919A463TCluster,Frequency,1000Genome


  • Cancer-related differential expression proteins derived from database dbDEPC:


    • No entry in dbDEPC was found



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