ID you entered:  ENSP00000263094

Ensembl protein: ENSP00000263094   

          Protein sequence 
Name: ABCA7
Description: ATP-binding cassette, sub-family A (ABC1), member 7 [Source:HGNC Symbol;Acc:HGNC:37]
Location:
            chr19 p13.3
Gene Ontology:
           Biological process 
           Molecular function 
           Cellular localization 
Interactions:   
          Interaction partner with cancer_related variations :  (  pvalue=0.724056, hypergeometric test )
                 1 
          Interaction partner with cancer related differentially expressed proteins :    NA
                         

  • Cancer-related variations in CanProVar:
    • NO.csIDvariationchange conservation+Domaincancer namePubMeddata source++validated dbSNP*interface
    1cs90301M153I1Ovarian Cancer18772890  21720365   TCGA, COSMIC
    2cs49437R286C-3Central Nervous System Neoplasms18772396   COSMIC
    3cs32477R1007H0Pancreatic Cancer21252315   COSMIC

    +Conservation of amino acid substitutions are defined here according to the BLOSUM62 matrix, conservative changes were those having a positive or neutral sign in the matrix, whereas non-conservative changes were those having a negative value (Cargill, et al. 1999).
    ++Data sources:  HPI,  COSMIC,  OMIM,  TCGA,  BIOMART,  Greenman2007,  Sjoblom2006,  Ding2008
    *Cross-reference databases: dbSNP
    Interface information was collected from Wang 2012


  • Non-cancer specific variations derived from database dbSNP:

    • NO.dbSNP_IDvariationvalidated
    1rs199776416N58KCluster
    2rs148580487P68AFrequency
    3rs146597357L85MFrequency
    4rs151054304P152LCluster,Frequency,1000Genome
    5rs3764645E188GCluster,Frequency,1000Genome,HapMap
    6rs138777686L190VFrequency
    7rs142809982A196VFrequency
    8rs72973581G215SCluster,Frequency,1000Genome
    9rs150820818S231NFrequency
    10rs77403558R285*Cluster,Frequency
    11rs3752232T319ACluster,Frequency,1000Genome
    12rs146086314R334WFrequency
    13rs143296441M354TCluster,1000Genome
    14rs146982710P364RFrequency
    15rs3764647H395RCluster,Frequency,1000Genome
    16rs10405305A414GCluster,Frequency,1000Genome
    17rs150867671R433QCluster,Frequency,1000Genome
    18rs3752233R463HCluster,Frequency,1000Genome
    19rs142700284P492TFrequency
    20rs200770980V499M1000Genome
    21rs144979723A589VFrequency
    22rs138819755L591PFrequency
    23rs144852598L620PFrequency
    24rs140710007F635L1000Genome
    25rs59851484A676TCluster,Frequency,1000Genome
    26rs3752239N718TCluster,Frequency,1000Genome
    27rs76282929Q758HCluster,Frequency,1000Genome
    28rs149949633G776RFrequency
    29rs199517653G826RCluster
    30rs149652747T849NFrequency
    31rs139251928D871HFrequency
    32rs74176364A877TCluster,Frequency,1000Genome
    33rs139415355A878TCluster
    34rs143718918R880QCluster,Frequency,1000Genome
    35rs111940546A914SCluster,Frequency
    36rs139214131R989HFrequency
    37rs143226982T990MFrequency
    38rs141322593R1026CFrequency
    39rs150012110G1111SFrequency
    40rs139615270L1116F1000Genome
    41rs147086830R1177QFrequency
    42rs142601420P1181L1000Genome
    43rs148143428G1190RCluster,Frequency
    44rs150557489A1223T1000Genome
    45rs114614802R1237HFrequency,1000Genome
    46rs138363826V1244MFrequency
    47rs3745842R1349QHapMap,1000Genome,Cluster,Frequency
    48rs139467472G1351SCluster,Frequency,1000Genome
    49rs144595576R1385QFrequency
    50rs112719199F1390LCluster,Frequency
    51rs145667385R1397CFrequency
    52rs145321888R1400HFrequency
    53rs149196228K1407RCluster,Frequency,1000Genome
    54rs140313804G1421VFrequency
    55rs145232000S1428LCluster,1000Genome
    56rs142617105A1441VCluster
    57rs138567176G1448DFrequency
    58rs144562001R1453GCluster,Frequency,1000Genome
    59rs144562001R1453CCluster,Frequency,1000Genome
    60rs151112873R1489QFrequency
    61rs201941781A1493TCluster
    62rs141113429R1496HCluster
    63rs149824618G1502VFrequency
    64rs113269196R1505HCluster,Frequency,1000Genome
    65rs192694824A1507T1000Genome
    66rs3752246G1527ACluster,Frequency,1000Genome,HapMap
    67rs140816246V1538IFrequency
    68rs145632609C1541Y1000Genome
    69rs187233122L1581F1000Genome
    70rs117187003V1599MCluster,Frequency,1000Genome
    71rs184590335S1629L1000Genome
    72rs143083561P1632LFrequency
    73rs141237099V1643MCluster,1000Genome
    74rs187637927S1645R1000Genome
    75rs4147918Q1686RCluster,Frequency,1000Genome
    76rs184218896I1690T1000Genome
    77rs142462701R1715HFrequency
    78rs146448899Q1722*Cluster,Frequency
    79rs73505232S1723LCluster,Frequency,1000Genome
    80rs188971580G1731S1000Genome
    81rs146448899Q1740*Cluster,Frequency
    82rs200364821R1764QCluster
    83rs139765732G1770ECluster,Frequency,1000Genome
    84rs145071620E1774K1000Genome
    85rs147558402R1778H1000Genome
    86rs148891749R1780WFrequency
    87rs200364821R1782QCluster
    88rs114782266R1812HCluster,Frequency,1000Genome
    89rs189602802A1919S1000Genome
    90rs114787084R1932CCluster,Frequency,1000Genome
    91rs142573667C1988F1000Genome
    92rs4147934A2045SCluster,Frequency,1000Genome
    93rs190013803F2071C1000Genome
    94rs139706726E2108K1000Genome


  • Cancer-related differential expression proteins derived from database dbDEPC:


    • No entry in dbDEPC was found



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