ID you entered:  ENSP00000263097

Ensembl protein: ENSP00000263097   

          Protein sequence 
Name: CNN2
Description: calponin 2 [Source:HGNC Symbol;Acc:HGNC:2156]
Location:
            chr19 p13.3
Gene Ontology:
           Biological process 
           Molecular function 
           Cellular localization 
Interactions:   
          Interaction partner with cancer_related variations :  (  pvalue=0.724056, hypergeometric test )
                 1 
          Interaction partner with cancer related differentially expressed proteins :  (  pvalue=0.21215, hypergeometric test )
                 1 
                         

  • Cancer-related variations in CanProVar:
    • NO.csIDvariationchange conservation+Domaincancer namePubMeddata source++validated dbSNP*interface
    1cs90880P284L-3Skin Cancer21984974   COSMIC
    2cs21786P301L-3Skin Cancer21984974   COSMIC
    3cs64576*310S-4Ovarian Cancer21720365   COSMIC

    +Conservation of amino acid substitutions are defined here according to the BLOSUM62 matrix, conservative changes were those having a positive or neutral sign in the matrix, whereas non-conservative changes were those having a negative value (Cargill, et al. 1999).
    ++Data sources:  HPI,  COSMIC,  OMIM,  TCGA,  BIOMART,  Greenman2007,  Sjoblom2006,  Ding2008
    *Cross-reference databases: dbSNP
    Interface information was collected from Wang 2012


  • Non-cancer specific variations derived from database dbSNP:

    • NO.dbSNP_IDvariationvalidated
    1rs149506955R35HFrequency
    2rs112302763V72ICluster,Frequency
    3rs142432171N109KCluster,Frequency
    4rs140890265G139RCluster,Frequency
    5rs138515103D156NCluster
    6rs148071782G185S1000Genome
    7rs181979586D202N1000Genome
    8rs199840457K234RCluster,Frequency
    9rs200505828T237IFrequency
    10rs200699249D238NCluster,Frequency
    11rs200177867M249TFrequency
    12rs201532581M249IFrequency
    13rs199741851G250VFrequency
    14rs77830704G263SCluster
    15rs78386506R266QCluster,1000Genome
    16rs75676484P271HCluster,Frequency
    17rs75676484P271RCluster,Frequency
    18rs78797154T278PCluster,Frequency
    19rs75602230T287ACluster,Frequency
    20rs74612849D292GCluster
    21rs76549406V296ACluster,Frequency
    22rs78251590P301HCluster
    23rs200263294Y309CCluster


  • Cancer-related differential expression proteins derived from database dbDEPC:

    • NO.dbDEPC_IDchangeratiocancer namedesignsample_controlsample_casesamplepubmed
    1EXP00001Non-small cell lung carcinomaMetastasisnon-metastatic CL1-0 lung cancer cellhighly metastatic CL1-5 lung cancer cellcell line17537172  
    2EXP00288Ovarian CancerMetastasislow malignant potential human epithelial ovarian cancer cell lines TOV-81Dhighly proliferative human epithelial ovarian cancer cell lines TOV-112Dcell line17892554  
    3EXP002360.59Breast CancerNormal vs. Cancernon-cancerous, normal breast epithelial (NBE) samplesestrogen receptor (ER)-positive (luminal subtype), invasive malignant breast epithelial (MBE) samplestissue20739354  
    4EXP002370.59Breast CancerNormal vs. Cancernon-cancerous, normal breast epithelial (NBE) samplesestrogen receptor (ER)-positive (luminal subtype), invasive malignant breast epithelial (MBE) samplestissue20739354  
    5EXP002791.7NonmelanomaNormal vs. Cancernon-HPV8-EXPressing adult keratinocytes cellsHPV8-E7 and HPV8-CEREXPressing adult keratinocytes cellscell line19243805  
    6EXP002112.1Breast CancerTreatment (tamoxifen-sensitive vs. tamoxifen-resistant)tumors were sensitive to tamoxifen therapytumors were resistant to therapytissue19329653  



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