ID you entered:  ENSP00000300954

Ensembl protein: ENSP00000300954   

          Protein sequence 
Name: PCSK4
Description: proprotein convertase subtilisin/kexin type 4 [Source:HGNC Symbol;Acc:HGNC:8746]
Location:
            chr19 p13.3
Gene Ontology:
           Biological process 
           Molecular function 
           Cellular localization 
Interactions:   
          Interaction partner with cancer_related variations :    NA
          Interaction partner with cancer related differentially expressed proteins :    NA

  • Cancer-related variations in CanProVar:
    • NO.csIDvariationchange conservation+Domaincancer namePubMeddata source++validated dbSNP*interface
    1cs22198V111G-3Ovarian Cancer21720365   COSMIC
    2cs26325S540C-1PF01483  Head and Neck Cancer21798893   COSMIC

    +Conservation of amino acid substitutions are defined here according to the BLOSUM62 matrix, conservative changes were those having a positive or neutral sign in the matrix, whereas non-conservative changes were those having a negative value (Cargill, et al. 1999).
    ++Data sources:  HPI,  COSMIC,  OMIM,  TCGA,  BIOMART,  Greenman2007,  Sjoblom2006,  Ding2008
    *Cross-reference databases: dbSNP
    Interface information was collected from Wang 2012


  • Non-cancer specific variations derived from database dbSNP:

    • NO.dbSNP_IDvariationvalidated
    1rs73516829P21SCluster,1000Genome
    2rs139319644Q81EFrequency
    3rs12972390R90HCluster,Frequency,1000Genome
    4rs143050585V116MFrequency
    5rs149457286T119MFrequency
    6rs200424032N130KCluster
    7rs200520395E132KCluster
    8rs200944148Q141*Cluster
    9rs183537877I161V1000Genome
    10rs186224387A221T1000Genome
    11rs143716976A224TFrequency
    12rs374835547G234SCluster
    13rs139666108S246NFrequency
    14rs116422632E262KFrequency
    15rs141648948D264NFrequency
    16rs137925566R266HFrequency
    17rs36123574T267MCluster,Frequency,1000Genome
    18rs143366021E277KCluster,Frequency,1000Genome
    19rs149185728R280WCluster,Frequency,1000Genome
    20rs138345395T292MCluster
    21rs374332963V322MCluster
    22rs184261134R330H1000Genome
    23rs138039746R330C1000Genome
    24rs150360487C338Y1000Genome
    25rs142695530G364RFrequency
    26rs11878809A456VCluster,Frequency,1000Genome,HapMap
    27rs202047165V476ICluster,1000Genome
    28rs202047165V476LCluster,1000Genome
    29rs141663994L510VFrequency
    30rs143738061F563LFrequency
    31rs113642524P586LCluster,Frequency
    32rs61733913T592ICluster,Frequency,1000Genome
    33rs116368142T641AFrequency,1000Genome
    34rs78359732C649FFrequency,1000Genome
    35rs76450268H703YCluster,Frequency,1000Genome
    36rs150434057S708WFrequency
    37rs114544630P747ACluster,Frequency,1000Genome


  • Cancer-related differential expression proteins derived from database dbDEPC:


    • No entry in dbDEPC was found



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