ID you entered:  ENSP00000301293

Ensembl protein: ENSP00000301293   

          Protein sequence 
Name: SEMA6B
Description: sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B [Source:HGNC Symbol;Acc:10739]
Location:
            chr19 p13.3
Gene Ontology:
           Biological process 
           Molecular function 
           Cellular localization 
Interactions:   
          Interaction partner with cancer_related variations :    NA
          Interaction partner with cancer related differentially expressed proteins :    NA

  • Cancer-related variations in CanProVar:
    • NO.csIDvariationchange conservation+Domaincancer namePubMeddata source++validated dbSNP*interface
    1cs42760E89Q2PF01403  Head and Neck Cancer21798893   COSMIC

    +Conservation of amino acid substitutions are defined here according to the BLOSUM62 matrix, conservative changes were those having a positive or neutral sign in the matrix, whereas non-conservative changes were those having a negative value (Cargill, et al. 1999).
    ++Data sources:  HPI,  COSMIC,  OMIM,  TCGA,  BIOMART,  Greenman2007,  Sjoblom2006,  Ding2008
    *Cross-reference databases: dbSNP
    Interface information was collected from Wang 2012


  • Non-cancer specific variations derived from database dbSNP:

    • NO.dbSNP_IDvariationvalidated
    1rs146754257N114SFrequency
    2rs142686737P366L1000Genome
    3rs146077209A390T1000Genome
    4rs142864702A408VCluster,Frequency,1000Genome
    5rs186951396T453R1000Genome
    6rs139857831V454IFrequency
    7rs183820829V518M1000Genome
    8rs142268874T579AFrequency
    9rs189240925R781L1000Genome


  • Cancer-related differential expression proteins derived from database dbDEPC:


    • No entry in dbDEPC was found



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