ID you entered:  ENSP00000301452

Ensembl protein: ENSP00000301452   

          Protein sequence 
Name: ACER1
Description: alkaline ceramidase 1 [Source:HGNC Symbol;Acc:HGNC:18356]
Location:
            chr19 p13.3
Gene Ontology:
           Biological process 
           Molecular function 
           Cellular localization 
Interactions:   
          Interaction partner with cancer_related variations :    NA
          Interaction partner with cancer related differentially expressed proteins :    NA

  • Cancer-related variations in CanProVar:
    • NO.csIDvariationchange conservation+Domaincancer namePubMeddata source++validated dbSNP*interface
    1cs86289R55C-3PF05875  Pancreatic Cancer21930502  21930507   BIOMART

    +Conservation of amino acid substitutions are defined here according to the BLOSUM62 matrix, conservative changes were those having a positive or neutral sign in the matrix, whereas non-conservative changes were those having a negative value (Cargill, et al. 1999).
    ++Data sources:  HPI,  COSMIC,  OMIM,  TCGA,  BIOMART,  Greenman2007,  Sjoblom2006,  Ding2008
    *Cross-reference databases: dbSNP
    Interface information was collected from Wang 2012


  • Non-cancer specific variations derived from database dbSNP:

    • NO.dbSNP_IDvariationvalidated
    1rs138171486N18TFrequency
    2rs149195870S22L1000Genome
    3rs202229449L47VCluster
    4rs72981971M74VCluster,Frequency,1000Genome
    5rs190388447I92T1000Genome
    6rs187325437V157M1000Genome
    7rs147699720V177MCluster,1000Genome
    8rs147053887V182ICluster,Frequency,1000Genome
    9rs151165925R191PCluster,1000Genome
    10rs151165925R191HCluster,1000Genome
    11rs76925618M221ICluster,Frequency,1000Genome
    12rs80167519R245WCluster,1000Genome


  • Cancer-related differential expression proteins derived from database dbDEPC:


    • No entry in dbDEPC was found



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