ID you entered:  ENSP00000302621

Ensembl protein: ENSP00000302621   

          Protein sequence 
Name: LRG1
Description: leucine-rich alpha-2-glycoprotein 1 [Source:HGNC Symbol;Acc:HGNC:29480]
Location:
            chr19 p13.3
Gene Ontology:
           Biological process 
           Molecular function 
           Cellular localization 
Interactions:   
          Interaction partner with cancer_related variations :    NA
          Interaction partner with cancer related differentially expressed proteins :    NA

  • Cancer-related variations in CanProVar:
    • NO.csIDvariationchange conservation+Domaincancer namePubMeddata source++validated dbSNP*interface
    1cs66003V275M1PF00560  Ovarian Cancer21720365   COSMIC
    2cs56949R291Q1Head and Neck Cancer21798893   COSMIC

    +Conservation of amino acid substitutions are defined here according to the BLOSUM62 matrix, conservative changes were those having a positive or neutral sign in the matrix, whereas non-conservative changes were those having a negative value (Cargill, et al. 1999).
    ++Data sources:  HPI,  COSMIC,  OMIM,  TCGA,  BIOMART,  Greenman2007,  Sjoblom2006,  Ding2008
    *Cross-reference databases: dbSNP
    Interface information was collected from Wang 2012


  • Non-cancer specific variations derived from database dbSNP:

    • NO.dbSNP_IDvariationvalidated
    1rs144276105S5RFrequency
    2rs116733978R8*Cluster,Frequency,1000Genome
    3rs115514161R8QCluster,Frequency,1000Genome
    4rs202194743D42VCluster
    5rs115346350R47C1000Genome
    6rs7251081G64SCluster,Frequency,1000Genome
    7rs192599339E96D1000Genome
    8rs114158631V120M1000Genome
    9rs966384P133SCluster,Frequency,1000Genome
    10rs139572824F136LFrequency
    11rs146014281L145VCluster
    12rs114295397E197KCluster,Frequency,1000Genome
    13rs149316385R216WFrequency
    14rs116144652P234LCluster,Frequency,1000Genome
    15rs116652365L248PCluster,Frequency,1000Genome
    16rs114858360R250SFrequency,1000Genome
    17rs150365846R260WCluster,Frequency,1000Genome
    18rs149207556L262MCluster
    19rs145196834N270IFrequency
    20rs139646557L279FCluster
    21rs144112190R291QFrequency
    22rs146810940R291WFrequency
    23rs148677930R328HFrequency
    24rs202102463T339MCluster


  • Cancer-related differential expression proteins derived from database dbDEPC:

    • NO.dbDEPC_IDchangeratiocancer namedesignsample_controlsample_casesamplepubmed
    1EXP002951.2Ovarian CancerNormal vs. Cancerserum of non-cancer controlsserum of ovarian carcinomatissue20162585  
    2EXP002951.4Ovarian CancerNormal vs. Cancerserum of non-cancer controlsserum of ovarian carcinomatissue20162585  
    3EXP002951.5Ovarian CancerNormal vs. Cancerserum of non-cancer controlsserum of ovarian carcinomatissue20162585  
    4EXP001111.9Hepatocellular CarcinomaTreatment (none vs curative radiofrequency ablation treatment)serum samples of HCC patient before treatment serum samples of HCC patients after curative radiofrequency ablation treatmenttissue16254924  
    5EXP002913.1Ovarian CancerTreatment (chemotherapy-sensitive vs. chemotherapy-resistant)"chemosensitive tissue (serous histology, stage IIIC ovarian cancer, progression-free interval of 23 months)""chemoresistant tissue (serous histology, stage IIIC ovarian cancer, progression-free interval of 0 months)"tissue19422301  



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