ID you entered:  ENSP00000304467

Ensembl protein: ENSP00000304467   

          Protein sequence 
Name: THOP1
Description: thimet oligopeptidase 1 [Source:HGNC Symbol;Acc:HGNC:11793]
Location:
            chr19 p13.3
Gene Ontology:
           Biological process 
           Molecular function 
           Cellular localization 
Interactions:   
          Interaction partner with cancer_related variations :  (  pvalue=0.329512, hypergeometric test )
                 5 
          Interaction partner with cancer related differentially expressed proteins :    NA
                         

  • Cancer-related variations in CanProVar:
    • NO.csIDvariationchange conservation+Domaincancer namePubMeddata source++validated dbSNP*interface
    1cs14247D109N1Ovarian Cancer18772890  21720365   TCGA, COSMIC
    2cs92629L182M2Ovarian Cancer18772890  21720365   TCGA, COSMIC
    3cs77262A573V0PF01432  Skin Cancer21984974   COSMIC

    +Conservation of amino acid substitutions are defined here according to the BLOSUM62 matrix, conservative changes were those having a positive or neutral sign in the matrix, whereas non-conservative changes were those having a negative value (Cargill, et al. 1999).
    ++Data sources:  HPI,  COSMIC,  OMIM,  TCGA,  BIOMART,  Greenman2007,  Sjoblom2006,  Ding2008
    *Cross-reference databases: dbSNP
    Interface information was collected from Wang 2012


  • Non-cancer specific variations derived from database dbSNP:

    • NO.dbSNP_IDvariationvalidated
    1rs76198851R36CCluster,Frequency,1000Genome
    2rs142015327E42KCluster,Frequency,1000Genome
    3rs141520907S106P1000Genome
    4rs143179443T186MFrequency
    5rs146186757L204VCluster,Frequency,1000Genome
    6rs142317993A299VCluster
    7rs146411808P327AFrequency
    8rs185080096R348H1000Genome
    9rs148139735C350RFrequency
    10rs141574284R418W1000Genome
    11rs138112717R441HCluster,Frequency,1000Genome
    12rs17855443Y471FCluster,Frequency
    13rs151055831T494IFrequency
    14rs182189341T566R1000Genome
    15rs199651055A607TCluster
    16rs187807565R626C1000Genome
    17rs139083127S635GFrequency
    18rs201634731P684LCluster


  • Cancer-related differential expression proteins derived from database dbDEPC:


    • No entry in dbDEPC was found



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