ID you entered:  ENSP00000306335

Ensembl protein: ENSP00000306335   

          Protein sequence 
Name: RFX2
Description: regulatory factor X, 2 (influences HLA class II expression) [Source:HGNC Symbol;Acc:HGNC:9983]
Location:
            chr19 p13.3
Gene Ontology:
           Biological process 
           Molecular function 
           Cellular localization 
Interactions:   
          Interaction partner with cancer_related variations :  (  pvalue=0.379258, hypergeometric test )
                 4 
          Interaction partner with cancer related differentially expressed proteins :    NA
                         

  • Cancer-related variations in CanProVar:
    • NO.csIDvariationchange conservation+Domaincancer namePubMeddata source++validated dbSNP*interface
    1cs3458A37G0PF04589  Breast Cancer16959974   HPI, COSMIC, Sjoblom2006
    2cs3457E110K1PF04589  Breast Cancer16959974   HPI, COSMIC, Sjoblom2006
    3cs12795T189S1Head and Neck Cancer21798893   COSMIC
    4cs41677V549L1Ovarian Cancer21720365   COSMIC

    +Conservation of amino acid substitutions are defined here according to the BLOSUM62 matrix, conservative changes were those having a positive or neutral sign in the matrix, whereas non-conservative changes were those having a negative value (Cargill, et al. 1999).
    ++Data sources:  HPI,  COSMIC,  OMIM,  TCGA,  BIOMART,  Greenman2007,  Sjoblom2006,  Ding2008
    *Cross-reference databases: dbSNP
    Interface information was collected from Wang 2012


  • Non-cancer specific variations derived from database dbSNP:

    • NO.dbSNP_IDvariationvalidated
    1rs142338131E5KFrequency
    2rs201485682R17HCluster
    3rs2288846A86TCluster,Frequency,1000Genome
    4rs150537865T118IFrequency
    5rs190511322G140E1000Genome
    6rs144698636A148T1000Genome
    7rs143838272G156VFrequency
    8rs77515817H166PCluster
    9rs199570398I188VCluster
    10rs78767825R271HCluster,Frequency,1000Genome
    11rs144879552G318SFrequency
    12rs34026770V329MCluster,Frequency,1000Genome
    13rs79564339F355VCluster,Frequency,1000Genome
    14rs189822363I392M1000Genome
    15rs138852957V424ICluster
    16rs148402356T531MFrequency
    17rs35216341E696KCluster,Frequency
    18rs141415407R702LFrequency


  • Cancer-related differential expression proteins derived from database dbDEPC:


    • No entry in dbDEPC was found



    [ continue search ]



    Dr. Jing Li's Group

    ©2015 Menghuan Zhang, Jing Li