ID you entered:  ENSP00000308734

Ensembl protein: ENSP00000308734   

          Protein sequence 
Name: MATK
Description: megakaryocyte-associated tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:6906]
Location:
            chr19 p13.3
Gene Ontology:
           Biological process 
           Molecular function 
           Cellular localization 
Interactions:   
          Interaction partner with cancer_related variations :  (  pvalue=0.0395521, hypergeometric test )
                 10 
          Interaction partner with cancer related differentially expressed proteins :    NA
                         

  • Cancer-related variations in CanProVar:
    • NO.csIDvariationchange conservation+Domaincancer namePubMeddata source++validated dbSNP*interface
    1cs2695A354T0PF07714  PF00069  Ovarian Cancer18428421  17344846   HPI, Greenman2007ERBB2, LYN, KIT
    2cs2694R503Q1Intestines Cancer18428421  17344846   Greenman2007
    3cs2694R503Q1Colorectal Cancer17344846   HPI

    +Conservation of amino acid substitutions are defined here according to the BLOSUM62 matrix, conservative changes were those having a positive or neutral sign in the matrix, whereas non-conservative changes were those having a negative value (Cargill, et al. 1999).
    ++Data sources:  HPI,  COSMIC,  OMIM,  TCGA,  BIOMART,  Greenman2007,  Sjoblom2006,  Ding2008
    *Cross-reference databases: dbSNP
    Interface information was collected from Wang 2012


  • Non-cancer specific variations derived from database dbSNP:

    • NO.dbSNP_IDvariationvalidated
    1rs151078102G15SCluster,Frequency
    2rs145727316R70LCluster,1000Genome
    3rs145727316R70HCluster,1000Genome
    4rs201459758R378QCluster
    5rs183239464S403R1000Genome
    6rs147891344E481D1000Genome
    7rs35351680A496TCluster,Frequency,1000Genome


  • Cancer-related differential expression proteins derived from database dbDEPC:


    • No entry in dbDEPC was found



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