ID you entered:  ENSP00000309493

Ensembl protein: ENSP00000309493   

          Protein sequence 
Name: GPRC6A
Description: G protein-coupled receptor, class C, group 6, member A [Source:HGNC Symbol;Acc:HGNC:18510]
Location:
            chr6 q22.1
Gene Ontology:
           Biological process 
           Molecular function 
           Cellular localization 
Interactions:   
          Interaction partner with cancer_related variations :    NA
          Interaction partner with cancer related differentially expressed proteins :    NA

  • Cancer-related variations in CanProVar:
    • NO.csIDvariationchange conservation+Domaincancer namePubMeddata source++validated dbSNP*interface
    1cs61836M77I1PF01094  Melanoma21499247   COSMIC
    2cs14801I99N-3PF01094  Ovarian Cancer21720365   COSMIC
    3cs94566K130T-1PF01094  Head and Neck Cancer21798893   COSMIC
    4cs59327L262P-3PF01094  Head and Neck Cancer21798893   COSMIC
    5cs79700D428G-1PF01094  Ovarian Cancer21720365   COSMIC
    6cs81304Q519*-4PF07562  Skin Cancer21984974   COSMIC

    +Conservation of amino acid substitutions are defined here according to the BLOSUM62 matrix, conservative changes were those having a positive or neutral sign in the matrix, whereas non-conservative changes were those having a negative value (Cargill, et al. 1999).
    ++Data sources:  HPI,  COSMIC,  OMIM,  TCGA,  BIOMART,  Greenman2007,  Sjoblom2006,  Ding2008
    *Cross-reference databases: dbSNP
    Interface information was collected from Wang 2012


  • Non-cancer specific variations derived from database dbSNP:

    • NO.dbSNP_IDvariationvalidated
    1rs78492331S18PFrequency,1000Genome
    2rs148708177P33L1000Genome
    3rs6907580R57*Cluster,Frequency,1000Genome
    4rs2274911P91SCluster,Frequency,1000Genome
    5rs185709000D101G1000Genome
    6rs28360548I144RCluster,Frequency,1000Genome
    7rs145460545R187QCluster,Frequency,1000Genome
    8rs149304182A224SFrequency
    9rs61745784V237MCluster,Frequency,1000Genome
    10rs140603319I254TFrequency
    11rs144964096H282RCluster,Frequency,1000Genome
    12rs117018536D371NFrequency,1000Genome
    13rs140120868R382GCluster,Frequency,1000Genome
    14rs187095771D401Y1000Genome
    15rs183900159L417I1000Genome
    16rs200889200R427WCluster
    17rs143913245F464YCluster,Frequency,1000Genome
    18rs138434111I482TCluster,1000Genome
    19rs80280966A492ECluster
    20rs143716393N510HCluster,Frequency,1000Genome
    21rs142066905P528SCluster,Frequency,1000Genome
    22rs35937022I599TCluster,Frequency,1000Genome
    23rs140601827L600FCluster,Frequency,1000Genome
    24rs184216909K625I1000Genome
    25rs144698290Q655*Cluster,Frequency,1000Genome
    26rs191632433F657L1000Genome
    27rs118009892T679MCluster,Frequency,1000Genome
    28rs139828071P704SFrequency
    29rs142578038T712MCluster,Frequency
    30rs148099318I768MFrequency
    31rs143644044F771YFrequency
    32rs149439793F771LFrequency
    33rs146895917K772TFrequency
    34rs139364930K772EFrequency
    35rs148346142K774KKL1000Genome
    36rs188971795G787D1000Genome
    37rs147708254M788LFrequency
    38rs142053954I843TFrequency
    39rs191908044G876S1000Genome
    40rs142518238S885YCluster,Frequency,1000Genome
    41rs41291912S886GCluster,Frequency
    42rs144545899A902PFrequency
    43rs41290852S924LCluster,Frequency,1000Genome


  • Cancer-related differential expression proteins derived from database dbDEPC:


    • No entry in dbDEPC was found



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