ID you entered:  ENSP00000324856

Ensembl protein: ENSP00000324856   

          Protein sequence 
Name: STK11
Description: serine/threonine kinase 11 [Source:HGNC Symbol;Acc:HGNC:11389]
Location:
            chr19 p13.3
Gene Ontology:
           Biological process 
           Molecular function 
           Cellular localization 
Interactions:   
          Interaction partner with cancer_related variations :  (  pvalue=0.000619436, hypergeometric test )
                 35 
          Interaction partner with cancer related differentially expressed proteins :    NA
                         

  • Cancer-related variations in CanProVar:
    • NO.csIDvariationchange conservation+Domaincancer namePubMeddata source++validated dbSNP*interface
    1cs82434M1V1Intestines Cancer COSMIC
    2cs973M1T-1Ovarian Cancer10389980   COSMIC
    3cs52645V4M1Lung Cancer24468202   COSMIC
    4cs92295P6Q-1Cervical Cancer19340305   COSMIC
    5cs982E14K1Cervical Cancer12533684   COSMIC
    6cs982E14K1Uterine Cancer12533684   HPI
    7cs63837S19*-4Cervical Cancer19340305   COSMIC
    8cs44682E33*-4Lung Cancer22980975  20668451   COSMIC
    9cs940Y36*-4Pancreatic Cancer10362809   COSMIC
    10cs977Q37*-4Lung Cancer18428421  15021901  12097271  18948947  
    17711506  20668451  16140923  
    17344846      		 Ding2008, COSMIC, Greenman2007
    11cs38498Q37K1Intestines Cancer COSMIC
    12cs8647Q37L-2Lung Cancer18948947   Ding2008, COSMIC
    13cs977Q37*-4Gastric Cancer21097718   COSMIC
    14cs91950R39C-3Liver Cancer COSMIC
    15cs979K44*-4Lung Cancer12097271   COSMIC
    16cs966Y49D-3Skin Cancer(Melanoma)10201537   COSMICRPS6KA3, CAB39, RPS6KB1,
    17cs10034Y49H2Intestines Cancer COSMICRPS6KA3, CAB39, RPS6KB1,
    18cs87228L50R-2Head and Neck Cancer23907151   COSMICRPS6KA3, CAB39, RPS6KB1,
    19cs8640G56W-2PF00069  PF07714  Lung Cancer18948947   Ding2008, COSMICRPS6KA3, CAB39, RPS6KB1,
    20cs30420G56V-3PF00069  PF07714  Lung Cancer COSMICRPS6KA3, CAB39, RPS6KB1,
    21cs18454E57*-4PF00069  PF07714  Cervical Cancer19340305   COSMICRPS6KA3, CAB39, RPS6KB1,
    22cs45233E57G-2PF00069  PF07714  Intestines Cancer COSMICRPS6KA3, CAB39, RPS6KB1,
    23cs13103Y60C-2PF00069  PF07714  Intestines Cancer COSMICRPS6KA3, CAB39, RPS6KB1,
    24cs951Y60*-4PF00069  PF07714  Lung Cancer18428421  15077168  18948947  21816872   Ding2008, COSMICRPS6KA3, CAB39, RPS6KB1,
    25cs97203K62*-4PF00069  PF07714  Lung Cancer22980975   COSMICRPS6KA3, CAB39, RPS6KB1,
    26cs15692E65G-2PF00069  PF07714  Intestines Cancer COSMICRPS6KA3, CAB39, RPS6KB1,
    27cs988E65*-4PF00069  PF07714  Lung Cancer15077168   COSMICRPS6KA3, CAB39, RPS6KB1,
    28cs946V66M1PF00069  PF07714  Cervical Cancer12533684   COSMICRPS6KA3, CAB39, RPS6KB1,
    29cs946V66M1PF00069  PF07714  Uterine Cancer12533684   HPIRPS6KA3, CAB39, RPS6KB1,
    30cs62752S69L-2PF00069  PF07714  Intestines Cancer COSMICRPS6KA3, CAB39, RPS6KB1,
    31cs943S69*-4PF00069  PF07714  Intestines Cancer COSMICRPS6KA3, CAB39, RPS6KB1,
    32cs943S69*-4PF00069  PF07714  Lung Cancer18594528   COSMICRPS6KA3, CAB39, RPS6KB1,
    33cs20818S69P-1PF00069  PF07714  Intestines Cancer COSMICRPS6KA3, CAB39, RPS6KB1,
    34cs968E70*-4PF00069  PF07714  Lung Cancer22980975  24236184  17676035   COSMICRPS6KA3, CAB39, RPS6KB1,
    35cs90929E70K1PF00069  PF07714  Intestines Cancer COSMICRPS6KA3, CAB39, RPS6KB1,
    36cs67866R75M-1PF00069  PF07714  Lymphocytic Leukemia22675565   COSMICRPS6KA3, CAB39, RPS6KB1,
    37cs40475K78R2PF00069  PF07714  Intestines Cancer COSMICRPS6KA3, CAB39, RPS6KB1,
    38cs8643K78E1PF00069  PF07714  Lung Cancer18948947   Ding2008, COSMICRPS6KA3, CAB39, RPS6KB1,
    39cs23007K84*-4PF00069  PF07714  Pancreatic Cancer COSMICRPS6KA3, CAB39, RPS6KB1,
    40cs61399R86G-2PF00069  PF07714  Other Cancer19892943   HPIRPS6KA3, CAB39, RPS6KB1,
    41cs61399R86G-2PF00069  PF07714  Lung Cancer19229701   COSMICRPS6KA3, CAB39, RPS6KB1,
    42cs942R87K2PF00069  PF07714  Skin Cancer(Melanoma) COSMICRPS6KA3, CAB39, RPS6KB1,
    43cs48276R87M-1PF00069  PF07714  Intestines Cancer COSMICRPS6KA3, CAB39, RPS6KB1,
    44cs942R87K2PF00069  PF07714  Skin Cancer18428421  17344846   Greenman2007RPS6KA3, CAB39, RPS6KB1,
    45cs12282I88M1PF00069  PF07714  Central Nervous System Neoplasms COSMICRPS6KA3, CAB39, RPS6KB1,
    46cs8646G91L-4PF00069  PF07714  Lung Cancer18948947   Ding2008, COSMICRPS6KA3, CAB39, RPS6KB1,
    47cs86830Q100E2PF00069  PF07714  Urinary Bladder Cancer19789314   COSMICRPS6KA3, CAB39, RPS6KB1,
    48cs13414H107R0PF00069  PF07714  Cervical Cancer19340305   COSMICRPS6KA3, CAB39, RPS6KB1,
    49cs47646K108*-4PF00069  PF07714  Lung Cancer COSMICRPS6KA3, CAB39, RPS6KB1,
    50cs49761Q112*-4PF00069  PF07714  Skin Cancer(Melanoma) COSMICRPS6KA3, CAB39, RPS6KB1,
    51cs959E120*-4PF00069  PF07714  Lung Cancer21532627  15077168  22980975   COSMICRPS6KA3, CAB39, RPS6KB1,
    52cs944Q123R1PF00069  PF07714  Other Cancer19892943   HPIRPS6KA3, CAB39, RPS6KB1,
    53cs93694Q123*-4PF00069  PF07714  Breast Cancer COSMICRPS6KA3, CAB39, RPS6KB1,
    54cs944Q123R1PF00069  PF07714  Lung Cancer17676035   COSMICRPS6KA3, CAB39, RPS6KB1,
    55cs93694Q123*-4PF00069  PF07714  Lung Cancer22980975   COSMICRPS6KA3, CAB39, RPS6KB1,
    56cs52734C132*-4PF00069  PF07714  Liver Cancer COSMICRPS6KA3, CAB39, RPS6KB1,
    57cs981G135R-2PF00069  PF07714  Skin Cancer(Melanoma)10201537   COSMICRPS6KA3, CAB39, RPS6KB1,
    58cs78348M136N-2PF00069  PF07714  Lung Cancer COSMICRPS6KA3, CAB39, RPS6KB1,
    59cs8637Q137*-4PF00069  PF07714  Lung Cancer18948947   Ding2008, COSMICRPS6KA3, CAB39, RPS6KB1,
    60cs71710K146*-4PF00069  PF07714  Lung Cancer COSMICRPS6KA3, CAB39, RPS6KB1,
    61cs22084Q152R1PF00069  PF07714  Intestines Cancer COSMICRPS6KA3, CAB39, RPS6KB1,
    62cs97624Q152K1PF00069  PF07714  Intestines Cancer COSMICRPS6KA3, CAB39, RPS6KB1,
    63cs66110Q152*-4PF00069  PF07714  Lung Cancer21532627   COSMICRPS6KA3, CAB39, RPS6KB1,
    64cs73916F157S-2PF00069  PF07714  Other Cancer19892943   HPIRPS6KA3, CAB39, RPS6KB1,
    65cs21687C158W-2PF00069  PF07714  Lung Cancer22975805   COSMICRPS6KA3, CAB39, RPS6KB1,
    66cs980Q159*-4PF00069  PF07714  Lung Cancer18428421  18594528  18948947  22975805   Ding2008, COSMICRPS6KA3, CAB39, RPS6KB1,
    67cs953L160P-3PF00069  PF07714  Uterine Cancer12533684   HPIRPS6KA3, CAB39, RPS6KB1,
    68cs953L160P-3PF00069  PF07714  Cervical Cancer12533684   COSMICRPS6KA3, CAB39, RPS6KB1,
    69cs963G163C-3PF00069  PF07714  Lung Cancer17676035   COSMICRPS6KA3, CAB39, RPS6KB1,
    70cs955G163D-1PF00069  PF07714  Testicular Cancer9887330  9605748  9887330   OMIM, COSMIC, HPIRPS6KA3, CAB39, RPS6KB1,
    71cs50019G163S0PF00069  PF07714  Intestines Cancer COSMICRPS6KA3, CAB39, RPS6KB1,
    72cs8642E165*-4PF00069  PF07714  Lung Cancer22980975  22327622  18948947   Ding2008, COSMICRPS6KA3, CAB39, RPS6KB1,
    73cs80549H168R0PF00069  PF07714  Lung Cancer COSMICRPS6KA3, CAB39, RPS6KB1,
    74cs28851Q170R1PF00069  PF07714  Intestines Cancer COSMICRPS6KA3, CAB39, RPS6KB1,
    75cs970Q170*-4PF00069  PF07714  Lung Cancer18428421  18549475  10208439  18948947   Ding2008, COSMICrs121913323RPS6KA3, CAB39, RPS6KB1,
    76cs92603Q170P-1PF00069  PF07714  Other Cancer19892943   HPIRPS6KA3, CAB39, RPS6KB1,
    77cs970Q170*-4PF00069  PF07714  Skin Cancer(Melanoma)10208439  24457427   COSMICrs121913323RPS6KA3, CAB39, RPS6KB1,
    78cs970Q170*-4PF00069  PF07714  Skin Cancer18428421  18549475  10208439  18948947   Ding2008rs121913323RPS6KA3, CAB39, RPS6KB1,
    79cs964G171S0PF00069  PF07714  Colorectal Cancer9731485   HPIRPS6KA3, CAB39, RPS6KB1,
    80cs964G171S0PF00069  PF07714  Intestines Cancer9731485   COSMICRPS6KA3, CAB39, RPS6KB1,
    81cs83939H174Y2PF00069  PF07714  Renal Cancer COSMICRPS6KA3, CAB39, RPS6KB1,
    82cs945H174R0PF00069  PF07714  Other Cancer19892943   HPIRPS6KA3, CAB39, RPS6KB1,
    83cs945H174R0PF00069  PF07714  Lung Cancer18549475   COSMICRPS6KA3, CAB39, RPS6KB1,
    84cs72203K175M-1PF00069  PF07714  Lymphocytic Leukemia22675565   COSMICRPS6KA3, CAB39, RPS6KB1,
    85cs19417D176H-1PF00069  PF07714  Lung Cancer22980975   COSMICRPS6KA3, CAB39, RPS6KB1,
    86cs15896D176A-2PF00069  PF07714  Lung Cancer COSMICRPS6KA3, CAB39, RPS6KB1,
    87cs960D176Y-3PF00069  PF07714  Lung Cancer18594528   COSMICRPS6KA3, CAB39, RPS6KB1,
    88cs960D176Y-3PF00069  PF07714  Other Cancer19892943   HPIRPS6KA3, CAB39, RPS6KB1,
    89cs21523I177N-3PF00069  PF07714  Other Cancer19892943   HPIRPS6KA3, CAB39, RPS6KB1,
    90cs78762K178*-4PF00069  PF07714  Renal Cancer COSMICRPS6KA3, CAB39, RPS6KB1,
    91cs52128P179L-3PF00069  PF07714  Lung Cancer20559149   COSMICRPS6KA3, CAB39, RPS6KB1,
    92cs47683P179S-1PF00069  PF07714  Prostate Cancer22722839   COSMICRPS6KA3, CAB39, RPS6KB1,
    93cs12695G180V-3PF00069  PF07714  Lung Cancer21532627   COSMICRPS6KA3, CAB39, RPS6KB1,
    94cs12662N181I-3PF00069  PF07714  Lung Cancer COSMICRPS6KA3, CAB39, RPS6KB1,
    95cs89747N181Y-2PF00069  PF07714  Lung Cancer COSMICRPS6KA3, CAB39, RPS6KB1,
    96cs20111N181E0PF00069  PF07714  Other Cancer19892943   HPIRPS6KA3, CAB39, RPS6KB1,
    97cs8644K191*-4PF00069  PF07714  Lung Cancer18948947   Ding2008, COSMICRPS6KA3, CAB39, RPS6KB1,
    98cs22599S193F-2PF00069  PF07714  Skin Cancer(Melanoma) COSMICRPS6KA3, CAB39, RPS6KB1,
    99cs969D194Y-3PF00069  PF07714  Lung Cancer18594528  18549475  22327622  22980975   COSMICrs121913315RPS6KA3, CAB39, RPS6KB1,
    100cs21541D194H-1PF00069  PF07714  Lung Cancer21816872   COSMICRPS6KA3, CAB39, RPS6KB1,
    101cs947D194V-3PF00069  PF07714  Lung Cancer10079245   HPI, COSMICRPS6KA3, CAB39, RPS6KB1,
    102cs969D194Y-3PF00069  PF07714  Skin Cancer(Melanoma)10208439   COSMICrs121913315RPS6KA3, CAB39, RPS6KB1,
    103cs954D194N1PF00069  PF07714  Intestines Cancer24797764   COSMICrs121913315RPS6KA3, CAB39, RPS6KB1,
    104cs954D194N1PF00069  PF07714  Lung Cancer17676035   COSMICrs121913315RPS6KA3, CAB39, RPS6KB1,
    105cs969D194Y-3PF00069  PF07714  Renal Cancer25078331   COSMICrs121913315RPS6KA3, CAB39, RPS6KB1,
    106cs47052L195M2PF00069  PF07714  Uterine Cancer COSMICRPS6KA3, CAB39, RPS6KB1,
    107cs8645G196V-3PF00069  PF07714  Lung Cancer18948947   Ding2008, COSMICRPS6KA3, CAB39, RPS6KB1,
    108cs8645G196V-3PF00069  PF07714  Skin Cancer(Melanoma) COSMICRPS6KA3, CAB39, RPS6KB1,
    109cs965E199Q2PF00069  PF07714  Lung Cancer18549475   COSMICRPS6KA3, CAB39, RPS6KB1,
    110cs41746E199D2PF00069  PF07714  Pancreatic Cancer24604757   COSMICRPS6KA3, CAB39, RPS6KB1,
    111cs937E199K1PF00069  PF07714  Intestines Cancer9731485   COSMICrs121913317RPS6KA3, CAB39, RPS6KB1,
    112cs965E199Q2PF00069  PF07714  Other Cancer19892943   HPIRPS6KA3, CAB39, RPS6KB1,
    113cs936E199*-4PF00069  PF07714  Lung Cancer18428421  22980975  18948947   Ding2008, COSMICrs121913317RPS6KA3, CAB39, RPS6KB1,
    114cs40885P203L-3PF00069  PF07714  Intestines Cancer COSMICRPS6KA3, CAB39, RPS6KB1,
    115cs976A205T0PF00069  PF07714  Other Cancer19892943   HPIRPS6KA3, CAB39, RPS6KB1,
    116cs976A205T0PF00069  PF07714  Head and Neck Cancer16407837   COSMICRPS6KA3, CAB39, RPS6KB1,
    117cs975D208N1PF00069  PF07714  Colorectal Cancer9731485   HPIRPS6KA3, CAB39, RPS6KB1,
    118cs975D208N1PF00069  PF07714  Intestines Cancer9731485   COSMICRPS6KA3, CAB39, RPS6KB1,
    119cs40340C210R-3PF00069  PF07714  Intestines Cancer COSMICRPS6KA3, CAB39, RPS6KB1,
    120cs972C210*-4PF00069  PF07714  Lung Cancer12097271   COSMICRPS6KA3, CAB39, RPS6KB1,
    121cs962Q214*-4PF00069  PF07714  Intestines Cancer22327622   COSMICRPS6KA3, CAB39, RPS6KB1,
    122cs941G215D-1PF00069  PF07714  Colorectal Cancer9731485   HPIRPS6KA3, CAB39, RPS6KB1,
    123cs12716G215S0PF00069  PF07714  Lung Cancer24468202   COSMICRPS6KA3, CAB39, RPS6KB1,
    124cs941G215D-1PF00069  PF07714  Intestines Cancer9731485   COSMICRPS6KA3, CAB39, RPS6KB1,
    125cs967S216F-2PF00069  PF07714  Other Cancer19892943   HPIRPS6KA3, CAB39, RPS6KB1,
    126cs967S216F-2PF00069  PF07714  Cervical Cancer19340305   COSMICRPS6KA3, CAB39, RPS6KB1,
    127cs967S216F-2PF00069  PF07714  Lung Cancer17676035   COSMICRPS6KA3, CAB39, RPS6KB1,
    128cs97389S216P-1PF00069  PF07714  Lung Cancer20668451   COSMICRPS6KA3, CAB39, RPS6KB1,
    129cs974Q220*-4PF00069  PF07714  Uterine Cancer18428421  18948947   Ding2008RPS6KA3, CAB39, RPS6KB1,
    130cs974Q220*-4PF00069  PF07714  Lung Cancer18428421  22980975  18948947  20559149   Ding2008, COSMICRPS6KA3, CAB39, RPS6KB1,
    131cs61329P221L-3PF00069  PF07714  Lung Cancer22980975   COSMICRPS6KA3, CAB39, RPS6KB1,
    132cs26294E223L-3PF00069  PF07714  Lung Cancer21816872   COSMICRPS6KA3, CAB39, RPS6KB1,
    133cs971E223*-4PF00069  PF07714  Lung Cancer22980975  12097271   COSMICRPS6KA3, CAB39, RPS6KB1,
    134cs28950E223V-2PF00069  PF07714  Other Cancer19892943   HPIRPS6KA3, CAB39, RPS6KB1,
    135cs37009T230P-1PF00069  PF07714  Other Cancer19892943   HPIRPS6KA3, CAB39, RPS6KB1,
    136cs984F231L0PF00069  PF07714  Cervical Cancer12533684   COSMICRPS6KA3, CAB39, RPS6KB1,
    137cs984F231L0PF00069  PF07714  Uterine Cancer12533684   HPIRPS6KA3, CAB39, RPS6KB1,
    138cs48592S232P-1PF00069  PF07714  Other Cancer19892943   HPIRPS6KA3, CAB39, RPS6KB1,
    139cs73255K235*-4PF00069  PF07714  Lung Cancer COSMICRPS6KA3, CAB39, RPS6KB1,
    140cs56758V236A0PF00069  PF07714  Skin Cancer(Melanoma) COSMICRPS6KA3, CAB39, RPS6KB1,
    141cs8641D237Y-3PF00069  PF07714  Lung Cancer18948947   Ding2008, COSMICRPS6KA3, CAB39, RPS6KB1,
    142cs51400D237G-1PF00069  PF07714  Intestines Cancer COSMICRPS6KA3, CAB39, RPS6KB1,
    143cs39916W239C-2PF00069  PF07714  Lung Cancer22980975   COSMICRPS6KA3, CAB39, RPS6KB1,
    144cs8638G242V-3PF00069  PF07714  Lung Cancer18948947   Ding2008, COSMICRPS6KA3, CAB39, RPS6KB1,
    145cs952G242R-2PF00069  PF07714  Lung Cancer17676035   COSMICRPS6KA3, CAB39, RPS6KB1,
    146cs97602G242W-2PF00069  PF07714  Lung Cancer COSMICRPS6KA3, CAB39, RPS6KB1,
    147cs92493L245F0PF00069  PF07714  Lung Cancer COSMICRPS6KA3, CAB39, RPS6KB1,
    148cs74305L245R-2PF00069  PF07714  Other Cancer19892943   HPIRPS6KA3, CAB39, RPS6KB1,
    149cs28327T250P-1PF00069  PF07714  Other Cancer19892943   HPIRPS6KA3, CAB39, RPS6KB1,
    150cs76232G251F-3PF00069  PF07714  Lung Cancer COSMICRPS6KA3, CAB39, RPS6KB1,
    151cs34781G251R-2PF00069  PF07714  Lung Cancer COSMICRPS6KA3, CAB39, RPS6KB1,
    152cs20274G251V-3PF00069  PF07714  Lung Cancer COSMICRPS6KA3, CAB39, RPS6KB1,
    153cs53171K262*-4PF00069  PF07714  Lung Cancer COSMICRPS6KA3, CAB39, RPS6KB1,
    154cs70920E265*-4PF00069  PF07714  Lung Cancer22980975   COSMICRPS6KA3, CAB39, RPS6KB1,
    155cs61824Y272H2PF00069  PF07714  Other Cancer19892943   HPIRPS6KA3, CAB39, RPS6KB1,
    156cs61824Y272H2PF00069  PF07714  Intestines Cancer COSMICRPS6KA3, CAB39, RPS6KB1,
    157cs948D277Y-3PF00069  PF07714  Other Cancer19892943   HPIRPS6KA3, CAB39, RPS6KB1,
    158cs948D277Y-3PF00069  PF07714  Lung Cancer18594528   COSMICRPS6KA3, CAB39, RPS6KB1,
    159cs44759G279F-3PF00069  PF07714  Lung Cancer21191700   COSMICRPS6KA3, CAB39, RPS6KB1,
    160cs939P281L-3PF00069  PF07714  Ovarian Cancer10429654   HPI, COSMICRPS6KA3, CAB39, RPS6KB1,
    161cs939P281L-3PF00069  PF07714  Gastric Cancer22723903   COSMICRPS6KA3, CAB39, RPS6KB1,
    162cs939P281L-3PF00069  PF07714  Lung Cancer17711506  18594528   COSMICRPS6KA3, CAB39, RPS6KB1,
    163cs939P281L-3PF00069  PF07714  Intestines Cancer9731485   COSMICRPS6KA3, CAB39, RPS6KB1,
    164cs950L285Q-2PF00069  PF07714  Other Cancer19892943   HPIRPS6KA3, CAB39, RPS6KB1,
    165cs23676K287*-4PF00069  PF07714  Lung Cancer22980975   COSMICRPS6KA3, CAB39, RPS6KB1,
    166cs75674R297G-2PF00069  PF07714  Intestines Cancer COSMICRPS6KA3, CAB39, RPS6KB1,
    167cs28465R297S-1PF00069  PF07714  Lung Cancer21532627   COSMICRPS6KA3, CAB39, RPS6KB1,
    168cs64530F298L0PF00069  PF07714  Cervical Cancer19340305   COSMICRPS6KA3, CAB39, RPS6KB1,
    169cs71614I303N-3PF00069  PF07714  Gastric Cancer COSMICRPS6KA3, CAB39, RPS6KB1,
    170cs97769I303S-2PF00069  PF07714  Biliary Tract Cancer24185509   COSMICRPS6KA3, CAB39, RPS6KB1,
    171cs8648R304G-2PF00069  PF07714  Lung Cancer21532627  18948947   Ding2008, COSMICRPS6KA3, CAB39, RPS6KB1,
    172cs10391R304W-3PF00069  PF07714  Cervical Cancer19340305   COSMICRPS6KA3, CAB39, RPS6KB1,
    173cs938W308L-2PF00069  Lung Cancer17711506  21521776   COSMICRPS6KA3, CAB39, RPS6KB1,
    174cs978P314H-2Intestines Cancer9809980  22895193   COSMIC
    175cs978P314H-2Colorectal Cancer9809980   HPI
    176cs987P324L-3Gastric Cancer9683800   HPI, COSMIC
    177cs961W332*-4Lung Cancer17711506  12097271   COSMIC
    178cs49685D350N1Intestines Cancer COSMIC
    179cs94161D350G-1Intestines Cancer COSMIC
    180cs92298D350E2Esophageal Cancer COSMIC
    181cs985F354L0Lung Cancer21816872  24956168  18549475  23907151  
    22460425  19229701      		 COSMIC
    182cs985F354L0Lymphocytic Leukemia24674452   COSMIC
    183cs985F354L0Breast Cancer23739063   COSMIC
    184cs985F354L0Head and Neck Cancer25234657   COSMIC
    185cs985F354L0Intestines Cancer9731485   COSMIC
    186cs985F354L0Colorectal Cancer9731485   HPI
    187cs949T367M-1Intestines Cancer9731485   COSMIC
    188cs949T367M-1Colorectal Cancer9731485   HPI
    189cs43902P369S-1Renal Cancer COSMIC
    190cs57918P373S-1Lung Cancer24468202   COSMIC
    191cs39184H379Q0Lung Cancer24468202   COSMIC
    192cs8639A389T0Lung Cancer18948947   Ding2008, COSMIC
    193cs41818V390M1Lung Cancer24468202   COSMIC
    194cs14622A397V0Lung Cancer24468202  22975805   COSMIC
    195cs21495K403I-3Lymphocytic Leukemia22675565   COSMIC
    196cs88644R409Q1Intestines Cancer COSMIC
    197cs957R409W-3Lung Cancer17676035   COSMIC
    198cs75779A414T0Pancreatic Cancer COSMIC
    199cs54609R425H0Lymphocytic Leukemia22675565   COSMIC
    200cs986R426W-3Lung Cancer18594528   COSMIC
    201cs31010*434Y-4Ovarian Cancer20826764   COSMIC

    +Conservation of amino acid substitutions are defined here according to the BLOSUM62 matrix, conservative changes were those having a positive or neutral sign in the matrix, whereas non-conservative changes were those having a negative value (Cargill, et al. 1999).
    ++Data sources:  HPI,  COSMIC,  OMIM,  TCGA,  BIOMART,  Greenman2007,  Sjoblom2006,  Ding2008
    *Cross-reference databases: dbSNP
    Interface information was collected from Wang 2012


  • Non-cancer specific variations derived from database dbSNP:

    • NO.dbSNP_IDvariationvalidated
    1rs148830698R42Q1000Genome
    2rs121913323Q170*Cluster
    3rs121913315D194YCluster
    4rs121913315D194NCluster
    5rs121913317E199*Cluster
    6rs121913317E199KCluster
    7rs185087320R211W1000Genome
    8rs121913322P281LCluster,1000Genome
    9rs59912467F354LCluster,Frequency,1000Genome
    10rs199973552A377VCluster


  • Cancer-related differential expression proteins derived from database dbDEPC:


    • No entry in dbDEPC was found



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