ID you entered:  ENSP00000348704

Ensembl protein: ENSP00000348704   

          Protein sequence 
Name: KPNA5
Description: karyopherin alpha 5 (importin alpha 6) [Source:HGNC Symbol;Acc:HGNC:6398]
Location:
            chr6 q22.1
Gene Ontology:
           Biological process 
           Molecular function 
           Cellular localization 
Interactions:   
          Interaction partner with cancer_related variations :  (  pvalue=0.3183, hypergeometric test )
                 5 
          Interaction partner with cancer related differentially expressed proteins :    NA
                         

  • Cancer-related variations in CanProVar:
    • NO.csIDvariationchange conservation+Domaincancer namePubMeddata source++validated dbSNP*interface
    1cs50876Q41K1PF01749  Ovarian Cancer21720365   COSMIC
    2cs3251F48L0PF01749  Breast Cancer18428421  16959974   COSMIC, Sjoblom2006
    3cs60214A97T0Hepatocellular Carcinoma21930502  21930507   BIOMART
    4cs3250R319S-1PF00514  Breast Cancer16959974   COSMIC
    5cs78764I355N-3PF00514  PF02985  Breast Cancer21930502  21930507   BIOMART
    6cs77305P384S-1PF00514  Melanoma21499247   COSMIC
    7cs17218A401S1PF00514  Head and Neck Cancer21798893   COSMIC

    +Conservation of amino acid substitutions are defined here according to the BLOSUM62 matrix, conservative changes were those having a positive or neutral sign in the matrix, whereas non-conservative changes were those having a negative value (Cargill, et al. 1999).
    ++Data sources:  HPI,  COSMIC,  OMIM,  TCGA,  BIOMART,  Greenman2007,  Sjoblom2006,  Ding2008
    *Cross-reference databases: dbSNP
    Interface information was collected from Wang 2012


  • Non-cancer specific variations derived from database dbSNP:

    • NO.dbSNP_IDvariationvalidated
    1rs137898003S16NCluster,Frequency,1000Genome
    2rs2243365P70SCluster,Frequency
    3rs140309737P77L1000Genome
    4rs148338986P79AFrequency
    5rs141534226D87NFrequency
    6rs147245391V165LCluster
    7rs140751697L209MCluster,Frequency
    8rs151204421K252NCluster,Frequency
    9rs140804688A292TFrequency
    10rs146135522R453C1000Genome
    11rs74502521I473T1000Genome
    12rs192935885Q522H1000Genome
    13rs150841721Q529RFrequency


  • Cancer-related differential expression proteins derived from database dbDEPC:


    • No entry in dbDEPC was found



    [ continue search ]



    Dr. Jing Li's Group

    ©2015 Menghuan Zhang, Jing Li