CanProVar 2.0:Human Cancer Proteome Variation Database

ID you entered: ENSP00000349087

Ensembl protein: ENSP00000349087

Protein sequence

Name: TMEM259

Description: transmembrane protein 259 [Source:HGNC Symbol;Acc:HGNC:17039]

Location:

chr19 p13.3

Gene Ontology:

Biological process

Molecular function

Cellular localization

Interactions:

Interaction partner with cancer_related variations : NA

Interaction partner with cancer related differentially expressed proteins : NA

Cancer-related variations in CanProVar:

NO.	csID	variation	change conservation⁺	Domain	cancer name	PubMed	data source⁺⁺	validated dbSNP*	interface
1	cs12952	E6K	1		Pancreatic Cancer		COSMIC

⁺Conservation of amino acid substitutions are defined here according to the BLOSUM62 matrix, conservative changes were those having a positive or neutral sign in the matrix, whereas non-conservative changes were those having a negative value (Cargill, et al. 1999).
⁺⁺Data sources: HPI, COSMIC, OMIM, TCGA, BIOMART, Greenman2007, Sjoblom2006, Ding2008
*Cross-reference databases: dbSNP
Interface information was collected from Wang 2012

Non-cancer specific variations derived from database dbSNP:

NO.	dbSNP_ID	variation	validated
1	rs141314760	V82I	Frequency
2	rs144593243	R107S	Frequency
3	rs137931484	A122T	Cluster
4	rs149855778	A187V	Frequency
5	rs142318806	R284Q	Cluster,1000Genome
6	rs202085162	R293C	Cluster
7	rs202006160	R459H	Cluster
8	rs1058810	P469T	Frequency,1000Genome
9	rs10401738	S486L	Cluster,Frequency,1000Genome
10	rs183061118	P504L	1000Genome
11	rs185964545	R564W	1000Genome
12	rs151265454	T594A	1000Genome
13	rs77868901	P606A	1000Genome

Cancer-related differential expression proteins derived from database dbDEPC:

NO.	dbDEPC_ID	change	ratio	cancer name	design	sample_control	sample_case	sample	pubmed
1	EXP00284			Testicular Cancer	Normal vs. Cancer	Human embryonic stem cells (hESC) line HUES-7	Human embryonal carcinoma cells (hECCs) line NT2/D1	cell line	18489135

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