ID you entered:  ENSP00000349428

Ensembl protein: ENSP00000349428   

          Protein sequence 
Name: PTBP1
Description: polypyrimidine tract binding protein 1 [Source:HGNC Symbol;Acc:HGNC:9583]
Location:
            chr19 p13.3
Gene Ontology:
           Biological process 
           Molecular function 
           Cellular localization 
Interactions:   
          Interaction partner with cancer_related variations :  (  pvalue=0.145809, hypergeometric test )
                 25 
          Interaction partner with cancer related differentially expressed proteins :  (  pvalue=0.0196533, hypergeometric test )
                 12 
                         

  • Cancer-related variations in CanProVar:
    • NO.csIDvariationchange conservation+Domaincancer namePubMeddata source++validated dbSNP*interface
    1cs71735T71M-1Head and Neck Cancer21984974   COSMIC
    2cs20713T138I-1Skin Cancer21984974   COSMIC
    3cs30762F222L0PF00076  Head and Neck Cancer21798893   COSMICSFPQ, HNRNPL, PTBP2, PTBP
    4cs30539G310R-2Head and Neck Cancer21798893   COSMIC
    5cs77924A311V0Ovarian Cancer18772890  21720365   TCGA, COSMIC

    +Conservation of amino acid substitutions are defined here according to the BLOSUM62 matrix, conservative changes were those having a positive or neutral sign in the matrix, whereas non-conservative changes were those having a negative value (Cargill, et al. 1999).
    ++Data sources:  HPI,  COSMIC,  OMIM,  TCGA,  BIOMART,  Greenman2007,  Sjoblom2006,  Ding2008
    *Cross-reference databases: dbSNP
    Interface information was collected from Wang 2012


  • Non-cancer specific variations derived from database dbSNP:

    • NO.dbSNP_IDvariationvalidated
    1rs140010693S16F1000Genome
    2rs202040078F29L1000Genome
    3rs140945539A54T1000Genome
    4rs11549885R64WHapMap
    5rs11549886S116LHapMap
    6rs150661031A173TFrequency
    7rs144400768A176V1000Genome
    8rs189076650H201Q1000Genome
    9rs201221864A229VCluster
    10rs147259741S288LCluster,Frequency,1000Genome
    11rs189842365A338T1000Genome
    12rs146498992V507IFrequency


  • Cancer-related differential expression proteins derived from database dbDEPC:


    • No entry in dbDEPC was found



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