CanProVar 2.0:Human Cancer Proteome Variation Database

ID you entered: ENSP00000357480

Ensembl protein: ENSP00000357480

Protein sequence

Name: NUS1

Description: nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) [Source:HGNC Symbol;Acc:HGNC:21042]

Location:

chr6 q22.1

Gene Ontology:

Biological process

Molecular function

Cellular localization

Interactions:

Interaction partner with cancer_related variations : ( pvalue=0.724056, hypergeometric test )

Interaction partner with cancer related differentially expressed proteins : ( pvalue=0.78785, hypergeometric test )

Cancer-related variations in CanProVar:

NO.	csID	variation	change conservation⁺	Domain	cancer name	PubMed	data source⁺⁺	validated dbSNP*	interface
1	cs96913	G53D	-1		Central Nervous System Neoplasms	18772396	COSMIC

⁺Conservation of amino acid substitutions are defined here according to the BLOSUM62 matrix, conservative changes were those having a positive or neutral sign in the matrix, whereas non-conservative changes were those having a negative value (Cargill, et al. 1999).
⁺⁺Data sources: HPI, COSMIC, OMIM, TCGA, BIOMART, Greenman2007, Sjoblom2006, Ding2008
*Cross-reference databases: dbSNP
Interface information was collected from Wang 2012

Non-cancer specific variations derived from database dbSNP:

NO.	dbSNP_ID	variation	validated
1	rs150646335	P169R	Frequency
2	rs28362518	N175Y	1000Genome
3	rs28362519	D179E	1000Genome
4	rs1052237	L210*	Cluster
5	rs1052237	L210S	Cluster
6	rs146171115	K214E	Cluster,Frequency,1000Genome
7	rs76776814	A227G	Cluster,Frequency
8	rs550676	Q283H	Cluster,Frequency,1000Genome

Cancer-related differential expression proteins derived from database dbDEPC:

NO.	dbDEPC_ID	change	ratio	cancer name	design	sample_control	sample_case	sample	pubmed
1	EXP00232			Breast Cancer	Normal vs. Cancer	normal breast tissue	pathological tissue (adenoma and invasive carcinoma)	tissue	20560667

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