CanProVar 2.0:Human Cancer Proteome Variation Database

ID you entered: ENSP00000357494

Ensembl protein: ENSP00000357494

Protein sequence

1 MKNIYCLIPKLVNFATLGCLWISVVQCTVLNSCLKSCVTNLGQQLDLGTPHNLSEPCIQG

61 CHFWNSVDQKNCALKCRESCEVGCSSAEGAYEEEVLENADLPTAPFASSIGSHNMTLRWK

121 SANFSGVKYIIQWKYAQLLGSWTYTKTVSRPSYVVKPLHPFTEYIFRVVWIFTAQLQLYS

181 PPSPSYRTHPHGVPETAPLIRNIESSSPDTVEVSWDPPQFPGGPILGYNLRLISKNQKLD

241 AGTQRTSFQFYSTLPNTIYRFSIAAVNEVGEGPEAESSITTSSSAVQQEEQWLFLSRKTS

301 LRKRSLKHLVDEAHCLRLDAIYHNITGISVDVHQQIVYFSEGTLIWAKKAANMSDVSDLR

361 IFYRGSGLISSISIDWLYQRMYFIMDELVCVCDLENCSNIEEITPPSISAPQKIVADSYN

421 GYVFYLLRDGIYRADLPVPSGRCAEAVRIVESCTLKDFAIKPQAKRIIYFNDTAQVFMST

481 FLDGSASHLILPRIPFADVKSFACENNDFLVTDGKVIFQQDALSFNEFIVGCDLSHIEEF

541 GFGNLVIFGSSSQLHPLPGRPQELSVLFGSHQALVQWKPPALAIGANVILISDIIELFEL

601 GPSAWQNWTYEVKVSTQDPPEVTHIFLNISGTMLNVPELQSAMKYKVSVRASSPKRPGPW

661 SEPSVGTTLVPASEPPFIMAVKEDGLWSKPLNSFGPGEFLSSDIGNVSDMDWYNNSLYYS

721 DTKGDVFVWLLNGTDISENYHLPSIAGAGALAFEWLGHFLYWAGKTYVIQRQSVLTGHTD

781 IVTHVKLLVNDMVVDSVGGYLYWTTLYSVESTRLNGESSLVLQTQPWFSGKKVIALTLDL

841 SDGLLYWLVQDSQCIHLYTAVLRGQSTGDTTITEFAAWSTSEISQNALMYYSGRLFWING

901 FRIITTQEIGQKTSVSVLEPARFNQFTIIQTSLKPLPGNFSFTPKVIPDSVQESSFRIEG

961 NASSFQILWNGPPAVDWGVVFYSVEFSAHSKFLASEQHSLPVFTVEGLEPYALFNLSVTP

1021 YTYWGKGPKTSLSLRAPETVPSAPENPRIFILPSGKCCNKNEVVVEFRWNKPKHENGVLT

1081 KFEIFYNISNQSITNKTCEDWIAVNVTPSVMSFQLEGMSPRCFIAFQVRAFTSKGPGPYA

1141 DVVKSTTSEINPFPHLITLLGNKIVFLDMDQNQVVWTFSAERVISAVCYTADNEMGYYAE

1201 GDSLFLLHLHNRSSSELFQDSLVFDITVITIDWISRHLYFALKESQNGMQVFDVDLEHKV

1261 KYPREVKIHNRNSTIISFSVYPLLSRLYWTEVSNFGYQMFYYSIISHTLHRILQPTATNQ

1321 QNKRNQCSCNVTEFELSGAMAIDTSNLEKPLIYFAKAQEIWAMDLEGCQCWRVITVPAML

1381 AGKTLVSLTVDGDLIYWIITAKDSTQIYQAKKGNGAIVSQVKALRSRHILAYSSVMQPFP

1441 DKAFLSLASDTVEPTILNATNTSLTIRLPLAKTNLTWYGITSPTPTYLVYYAEVNDRKNS

1501 SDLKYRILEFQDSIALIEDLQPFSTYMIQIAVKNYYSDPLEHLPPGKEIWGKTKNGVPEA

1561 VQLINTTVRSDTSLIISWRESHKPNGPKESVRYQLAISHLALIPETPLRQSEFPNGRLTL

1621 LVTRLSGGNIYVLKVLACHSEEMWCTESHPVTVEMFNTPEKPYSLVPENTSLQFNWKAPL

1681 NVNLIRFWVELQKWKYNEFYHVKTSCSQGPAYVCNITNLQPYTSYNVRVVVVYKTGENST

1741 SLPESFKTKAGVPNKPGIPKLLEGSKNSIQWEKAEDNGCRITYYILEIRKSTSNNLQNQN

1801 LRWKMTFNGSCSSVCTWKSKNLKGIFQFRVVAANNLGFGEYSGISENIILVGDDFWIPET

1861 SFILTIIVGIFLVVTIPLTFVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLAN

1921 ACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVK

1981 TLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRK

2041 ARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKI

2101 GDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQ

2161 PYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRN

2221 FFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATE

2281 CGQGEEKSEGPLGSQESESCGLRKEEKEPHADKDFCQEKQVAYCPSGKPEGLNYACLTHS

2341 GYGDGSD*

. cancer related . dbSNP

Name: ROS1

Description: ROS proto-oncogene 1 , receptor tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:10261]

Location:

chr6 q22.1

Gene Ontology:

Biological process

Molecular function

Cellular localization

Interactions:

Interaction partner with cancer_related variations : ( pvalue=0.278331, hypergeometric test )

Interaction partner with cancer related differentially expressed proteins : NA

Cancer-related variations in CanProVar:

NO.	csID	variation	change conservation⁺	Domain	cancer name	PubMed	data source⁺⁺	validated dbSNP*	interface
1	cs59599	P9S	-1		Skin Cancer(Melanoma)		COSMIC
2	cs64952	C19S	-1		Renal Cancer		COSMIC
3	cs67331	L47F	0		Skin Cancer(Melanoma)		COSMIC
4	cs91764	G48D	-1		Intestines Cancer		COSMIC
5	cs47939	L53M	2		Renal Cancer		COSMIC
6	cs40537	N65S	1		Skin Cancer(Melanoma)		COSMIC
7	cs95703	C72R	-3		Uterine Cancer		COSMIC
8	cs52268	S112R	-1	PF00041	Head and Neck Cancer	21798893	COSMIC		PTPN6
9	cs84091	R118G	-2	PF00041	Skin Cancer	21984974	COSMIC		PTPN6
10	cs90843	R118Q	1	PF00041	Intestines Cancer		COSMIC		PTPN6
11	cs90843	R118Q	1	PF00041	Uterine Cancer		COSMIC		PTPN6
12	cs38317	A122V	0	PF00041	Esophageal Cancer	22877736	COSMIC		PTPN6
13	cs17232	G126E	-2	PF00041	Skin Cancer(Melanoma)		COSMIC		PTPN6
14	cs35063	T145P	-1	PF00041	Lymphocytic Leukemia		COSMIC		PTPN6
15	cs75017	K146N	0	PF00041	Intestines Cancer		COSMIC		PTPN6
16	cs94371	V148M	1	PF00041	Intestines Cancer		COSMIC		PTPN6
17	cs15334	P151S	-1	PF00041	Intestines Cancer	23856246	COSMIC		PTPN6
18	cs50856	Q177*	-4		Ovarian Cancer	21720365	COSMIC
19	cs42482	H189Y	2		Breast Cancer		COSMIC
20	cs53990	G192R	-2		Skin Cancer(Melanoma)		COSMIC
21	cs57473	P194S	-1		Urinary Bladder Cancer		COSMIC
22	cs65823	P198L	-3		Lung Cancer	20668451	COSMIC		PTPN6
23	cs49292	Q237P	-1	PF00041	Skin Cancer(Melanoma)	22622578	COSMIC		PTPN6
24	cs64264	Q237*	-4	PF00041	Skin Cancer(Melanoma)		COSMIC		PTPN6
25	cs88591	T243K	-1	PF00041	Renal Cancer		COSMIC		PTPN6
26	cs67264	R245I	-3	PF00041	Uterine Cancer		COSMIC		PTPN6
27	cs22069	F250L	0	PF00041	Uterine Cancer		COSMIC		PTPN6
28	cs85085	K298*	-4		Intestines Cancer		COSMIC
29	cs97939	T299A	0		Pancreatic Cancer		COSMIC
30	cs18990	R304I	-3		Uterine Cancer		COSMIC
31	cs77115	L306V	1		Gastric Cancer		COSMIC
32	cs40789	K307N	0		Intestines Cancer		COSMIC
33	cs11939	V310I	3		Intestines Cancer		COSMIC
34	cs67662	E312G	-2		Intestines Cancer		COSMIC
35	cs59274	R317W	-3		Skin Cancer	21984974	COSMIC
36	cs59274	R317W	-3		Lymphocytic Leukemia	24145436	COSMIC
37	cs56108	H323Q	0		Pancreatic Cancer	22156295	COSMIC
38	cs61449	I325N	-3		Breast Cancer	20668451	COSMIC
39	cs94600	G327E	-2		Skin Cancer(Melanoma)		COSMIC
40	cs97908	S329C	-1		Urinary Bladder Cancer	24121792	COSMIC
41	cs69127	V337L	1		Lung Cancer		COSMIC
42	cs13881	W346C	-2		Lung Cancer	22980975	COSMIC
43	cs21766	A350S	1		Intestines Cancer		COSMIC
44	cs67872	R360I	-3		Intestines Cancer	22895193	COSMIC
45	cs67872	R360I	-3		Lymphocytic Leukemia	23856246	COSMIC
46	cs67872	R360I	-3		Uterine Cancer		COSMIC
47	cs72181	L368F	0		Intestines Cancer		COSMIC
48	cs33800	L368I	2		Skin Cancer(Melanoma)		COSMIC
49	cs12399	S370P	-1		Intestines Cancer		COSMIC
50	cs37383	S370Y	-2		Ovarian Cancer	21720365	COSMIC
51	cs95089	R380I	-3		Intestines Cancer		COSMIC
52	cs65838	F383S	-2		Gastric Cancer		COSMIC
53	cs14348	I384F	0		Lung Cancer		COSMIC
54	cs73998	L388V	1		Central Nervous System Neoplasms		COSMIC
55	cs14034	E395D	2		Uterine Cancer		COSMIC
56	cs63323	S398*	-4		Head and Neck Cancer	21798893	COSMIC
57	cs62038	E402K	1		Skin Cancer(Melanoma)		COSMIC
58	cs17256	S409I	-2		Urinary Bladder Cancer		COSMIC
59	cs31287	Q412K	1		Prostate Cancer	22610119	COSMIC
60	cs17637	Y419C	-2		Intestines Cancer		COSMIC
61	cs4455	Y419H	2		Gastric Cancer	22037554 18428421 17344846	HPI, COSMIC, Greenman2007
62	cs30421	G421W	-2		Lung Cancer	23856246	COSMIC
63	cs72065	Y422D	-3		Breast Cancer		COSMIC
64	cs35145	R428I	-3		Intestines Cancer		COSMIC
65	cs18528	S440F	-2		Head and Neck Cancer	21984974	COSMIC
66	cs84176	R448G	-2		Gastric Cancer		COSMIC
67	cs79463	K456T	-1		Liver Cancer		COSMIC
68	cs53761	R466Q	1		Uterine Cancer		COSMIC
69	cs47602	I468L	2		Skin Cancer(Melanoma)		COSMIC
70	cs73875	R493C	-3		Skin Cancer(Melanoma)		COSMIC
71	cs21297	T512S	1		Lung Cancer		COSMIC
72	cs24390	S524P	-1		Intestines Cancer		COSMIC
73	cs96346	E527K	1		Intestines Cancer		COSMIC
74	cs96346	E527K	1		Skin Cancer(Melanoma)		COSMIC
75	cs64722	E539*	-4		Uterine Cancer		COSMIC
76	cs47105	S551F	-2		Breast Cancer		COSMIC
77	cs62737	R560C	-3		Breast Cancer	20668451	COSMIC
78	cs20066	P561L	-3		Urinary Bladder Cancer		COSMIC
79	cs19692	E596K	1		Breast Cancer		COSMIC
80	cs95212	V614A	0		Lung Cancer		COSMIC
81	cs73798	P620L	-3		Skin Cancer(Melanoma)		COSMIC
82	cs73711	E621K	1		Skin Cancer(Melanoma)		COSMIC
83	cs80369	G658S	0		Skin Cancer(Melanoma)		COSMIC
84	cs66171	V681A	0		Lung Cancer		COSMIC
85	cs16252	K682Q	1		Uterine Cancer		COSMIC
86	cs60265	K682R	2		Skin Cancer(Melanoma)		COSMIC
87	cs39277	G705E	-2		Skin Cancer(Melanoma)	24265154	COSMIC
88	cs46531	D711N	1		Lung Cancer		COSMIC
89	cs52592	Y713F	3		Intestines Cancer		COSMIC
90	cs89667	S716I	-2		Lung Cancer	20668451	COSMIC
91	cs83791	Y718*	-4		Uterine Cancer		COSMIC
92	cs66572	D725N	1		Renal Cancer		COSMIC
93	cs66572	D725N	1		Intestines Cancer	22810696	COSMIC
94	cs53723	F727S	-2		Lung Cancer	20668451	COSMIC
95	cs16196	G733R	-2		Skin Cancer(Melanoma)		COSMIC
96	cs62885	E738G	-2		Lung Cancer		COSMIC
97	cs21726	E738D	2		Intestines Cancer		COSMIC
98	cs64029	L742I	2		Uterine Cancer		COSMIC
99	cs59202	P743S	-1		Lymphocytic Leukemia	23415222	COSMIC
100	cs30129	A746V	0		Skin Cancer(Melanoma)		COSMIC
101	cs62033	G757S	0		Intestines Cancer		COSMIC
102	cs73081	D780E	2		Renal Cancer		COSMIC
103	cs98051	D780Y	-3		Uterine Cancer		COSMIC
104	cs51680	V789A	0		Lung Cancer		COSMIC
105	cs64516	M792I	1		Thyroid Carcinoma		COSMIC
106	cs41196	S808L	-2		Skin Cancer(Melanoma)		COSMIC
107	cs69355	L814I	2		Lymphocytic Leukemia	23856246	COSMIC
108	cs53949	P826S	-1		Liver Cancer	23788652	COSMIC
109	cs79760	G830W	-2		Lung Cancer		COSMIC
110	cs39084	Q850E	2		Lung Cancer		COSMIC
111	cs57485	I855M	1		Breast Cancer		COSMIC
112	cs62113	H856Y	2		Skin Cancer(Melanoma)		COSMIC
113	cs94471	V861I	3		Head and Neck Cancer	21798893	COSMIC
114	cs10472	L862F	0		Skin Cancer(Melanoma)		COSMIC
115	cs16299	R863W	-3		Skin Cancer(Melanoma)		COSMIC
116	cs16299	R863W	-3		Uterine Cancer		COSMIC
117	cs4457	Q865H	0		Non-small cell lung carcinoma	17344846	HPI
118	cs58976	Q865R	1		Intestines Cancer		COSMIC
119	cs4457	Q865H	0		Lung Cancer	18428421 16140923 17344846	COSMIC, Greenman2007
120	cs86795	T880S	1		Prostate Cancer	22722839	COSMIC
121	cs46903	S884F	-2		Skin Cancer(Melanoma)	21499247	COSMIC
122	cs40175	Y891C	-2		Lung Cancer	20668451	COSMIC
123	cs38653	S914N	1		Intestines Cancer	23700467	COSMIC
124	cs76230	V915I	3		Breast Cancer	22495314	COSMIC
125	cs33110	L918V	1		Lung Cancer	22980975	COSMIC
126	cs17204	E919K	1		Uterine Cancer		COSMIC
127	cs32414	S932T	1		Breast Cancer		COSMIC
128	cs44425	L933R	-2		Lymphocytic Leukemia	22158541	COSMIC
129	cs50678	S941F	-2		Skin Cancer(Melanoma)	22622578	COSMIC
130	cs37773	W969C	-2		Esophageal Cancer	23525077	COSMIC
131	cs67636	P973H	-2		Ovarian Cancer		COSMIC
132	cs47952	Y982F	3		Lung Cancer		COSMIC
133	cs31626	H989Y	2		Skin Cancer(Melanoma)		COSMIC
134	cs44496	F992L	0		Ovarian Cancer		COSMIC
135	cs61609	A994V	0		Lung Cancer	22980975	COSMIC
136	cs71239	A994D	-2		Central Nervous System Neoplasms		COSMIC
137	cs41020	S995C	-1		Thyroid Carcinoma		COSMIC
138	cs43301	E996K	1		Skin Cancer(Melanoma)	24265154	COSMIC
139	cs10439	V1002L	1		Liver Cancer		COSMIC
140	cs68326	P1020H	-2		Thyroid Carcinoma		COSMIC
141	cs33915	Y1023H	2		Ovarian Cancer		COSMIC
142	cs39529	G1025R	-2		Skin Cancer(Melanoma)		COSMIC
143	cs73130	T1030I	-1		Renal Cancer	23797736	COSMIC
144	cs70097	R1035*	-4		Central Nervous System Neoplasms		COSMIC
145	cs70097	R1035*	-4		Skin Cancer(Melanoma)	22622578	COSMIC
146	cs80260	A1043S	1		Lung Cancer	22941189 22941188	COSMIC
147	cs44891	I1051V	3		Urinary Bladder Cancer		COSMIC
148	cs33748	P1053R	-2		Urinary Bladder Cancer		COSMIC
149	cs77711	C1058G	-3		Lung Cancer		COSMIC		PTPN6
150	cs20088	K1071*	-4	PF00041	Central Nervous System Neoplasms	22722829	COSMIC		PTPN6
151	cs42844	E1075G	-2	PF00041	Pancreatic Cancer		COSMIC		PTPN6
152	cs36262	K1081Q	1	PF00041	Intestines Cancer	22810696	COSMIC		PTPN6
153	cs96405	E1083K	1	PF00041	Skin Cancer(Melanoma)		COSMIC		PTPN6
154	cs35821	S1089C	-1	PF00041	Lung Cancer		COSMIC		PTPN6
155	cs46039	Q1091R	1	PF00041	Prostate Cancer	23265383	COSMIC		PTPN6
156	cs59000	S1092N	1	PF00041	Skin Cancer(Melanoma)		COSMIC		PTPN6
157	cs97149	D1100E	2	PF00041	Intestines Cancer		COSMIC		PTPN6
158	cs44098	W1101*	-4	PF00041	Skin Cancer(Melanoma)	24265154	COSMIC		PTPN6
159	cs86414	P1108S	-1	PF00041	Skin Cancer(Melanoma)	24265154	COSMIC		PTPN6
160	cs86808	M1111I	1	PF00041	Lung Cancer	22941188	COSMIC		PTPN6
161	cs20801	R1121I	-3	PF00041	Uterine Cancer		COSMIC		PTPN6
162	cs11681	R1129S	-1	PF00041	Lung Cancer		COSMIC		PTPN6
163	cs72041	A1140T	0		Intestines Cancer		COSMIC		PTPN6
164	cs52788	V1143A	0		Intestines Cancer		COSMIC
165	cs27143	E1149K	1		Lung Cancer		COSMIC
166	cs73150	P1152T	-1		Gastric Cancer		COSMIC
167	cs70308	P1154S	-1		Skin Cancer(Melanoma)		COSMIC
168	cs68524	K1163N	0		Intestines Cancer		COSMIC
169	cs59934	T1177M	-1		Intestines Cancer		COSMIC
170	cs93091	A1180T	0		Uterine Cancer		COSMIC
171	cs93091	A1180T	0		Skin Cancer(Melanoma)		COSMIC
172	cs27448	D1192V	-3		Gastric Cancer		COSMIC
173	cs93960	G1196R	-2		Skin Cancer(Melanoma)	21499247	COSMIC
174	cs43607	E1200D	2		Head and Neck Cancer	21798893	COSMIC
175	cs63338	N1211T	0		Intestines Cancer	22810696	COSMIC
176	cs12621	R1212H	0		Uterine Cancer		COSMIC
177	cs30661	D1225H	-1		Lung Cancer	20668451	COSMIC
178	cs12134	E1244*	-4		Uterine Cancer		COSMIC
179	cs59167	P1263H	-2		Central Nervous System Neoplasms	23917401	COSMIC
180	cs75689	P1263F	-4		Skin Cancer	21984974	COSMIC
181	cs66496	I1268T	-1		Skin Cancer(Melanoma)		COSMIC
182	cs88558	S1273*	-4		Skin Cancer(Melanoma)		COSMIC
183	cs26431	T1274K	-1		Renal Cancer	22138691	COSMIC
184	cs22586	S1277F	-2		Skin Cancer(Melanoma)	22622578	COSMIC
185	cs50487	P1282S	-1		Skin Cancer(Melanoma)		COSMIC
186	cs45379	S1293F	-2		Skin Cancer(Melanoma)		COSMIC
187	cs17789	N1294S	1		Uterine Cancer		COSMIC
188	cs61106	F1295V	-1		Skin Cancer	21984974	COSMIC
189	cs75454	R1311Q	1		Uterine Cancer		COSMIC
190	cs81741	R1324M	-1		Uterine Cancer		COSMIC
191	cs31365	R1324S	-1		Uterine Cancer		COSMIC
192	cs23870	E1333K	1		Skin Cancer(Melanoma)		COSMIC
193	cs53329	E1348D	2		Intestines Cancer		COSMIC
194	cs59142	P1350Q	-1		Renal Cancer		COSMIC
195	cs10347	E1366*	-4		Liver Cancer	23788652	COSMIC
196	cs58506	I1374F	0		Renal Cancer	23797736	COSMIC
197	cs58506	I1374F	0		Lung Cancer		COSMIC
198	cs82650	T1384S	1		Skin Cancer(Melanoma)		COSMIC
199	cs97571	I1399V	3		Ovarian Cancer	21720365	COSMIC
200	cs61680	I1399T	-1		Intestines Cancer		COSMIC
201	cs97571	I1399V	3		Intestines Cancer		COSMIC
202	cs81641	K1422N	0		Gastric Cancer		COSMIC
203	cs47264	S1434L	-2		Skin Cancer	21984974	COSMIC
204	cs12724	P1440S	-1		Uterine Cancer		COSMIC
205	cs12724	P1440S	-1		Skin Cancer(Melanoma)		COSMIC
206	cs93964	F1444V	-1		Lung Cancer	22980975	COSMIC
207	cs36321	L1445Q	-2		Renal Cancer		COSMIC
208	cs53933	D1450Y	-3		Intestines Cancer		COSMIC
209	cs82737	A1459T	0		Lung Cancer		COSMIC
210	cs96458	Y1487D	-3		Lymphocytic Leukemia	23297126	COSMIC
211	cs53907	Y1487F	3		Ovarian Cancer		COSMIC
212	cs83252	V1489F	-1		Lung Cancer		COSMIC
213	cs46508	N1495S	1		Intestines Cancer		COSMIC
214	cs35020	N1495D	1		Ovarian Cancer	21720365	COSMIC
215	cs69510	I1514M	1		Renal Cancer		COSMIC
216	cs50362	P1539S	-1		Skin Cancer(Melanoma)		COSMIC
217	cs66426	G1546E	-2		Uterine Cancer		COSMIC
218	cs52798	G1551E	-2		Lung Cancer		COSMIC
219	cs44658	K1552T	-1		Intestines Cancer		COSMIC
220	cs40026	V1557I	3		Renal Cancer		COSMIC	rs150852319
221	cs39984	R1569Q	1		Gastric Cancer		COSMIC
222	cs36399	R1569W	-3		Skin Cancer(Melanoma)		COSMIC	rs199762082
223	cs46629	S1573N	1		Intestines Cancer		COSMIC
224	cs98463	R1579K	2		Skin Cancer(Melanoma)		COSMIC
225	cs85136	S1581C	-1		Urinary Bladder Cancer		COSMIC
226	cs62460	E1589*	-4		Intestines Cancer		COSMIC
227	cs78416	P1607L	-3		Skin Cancer(Melanoma)		COSMIC
228	cs52640	P1614S	-1		Skin Cancer(Melanoma)		COSMIC
229	cs81421	S1626C	-1		Lung Cancer	22941189	COSMIC
230	cs78463	G1627D	-1		Skin Cancer(Melanoma)		COSMIC
231	cs49554	H1639Y	2		Lymphocytic Leukemia	23297126	COSMIC
232	cs38254	E1642K	1		Skin Cancer(Melanoma)	24265154	COSMIC
233	cs60584	K1661Q	1		Breast Cancer		COSMIC		PTPN6
234	cs4459	V1666I	3		Central Nervous System Neoplasms		COSMIC		PTPN6
235	cs87291	P1667L	-3		Gastric Cancer		COSMIC		PTPN6
236	cs40554	P1679Q	-1	PF00041	Gastric Cancer	22484628	COSMIC		PTPN6
237	cs33940	V1682F	-1	PF00041	Lung Cancer		COSMIC		PTPN6
238	cs79464	W1694*	-4	PF00041	Breast Cancer		COSMIC		PTPN6
239	cs43318	S1705L	-2	PF00041	Skin Cancer(Melanoma)	24265154	COSMIC		PTPN6
240	cs79750	S1707N	1	PF00041	Skin Cancer(Melanoma)		COSMIC		PTPN6
241	cs21169	Y1712S	-2	PF00041	Lymphocytic Leukemia	22158541	COSMIC		PTPN6
242	cs45424	T1723S	1	PF00041	Lymphocytic Leukemia	24145436	COSMIC		PTPN6
243	cs89006	V1729L	1	PF00041	Intestines Cancer		COSMIC		PTPN6
244	cs95491	E1737*	-4	PF00041	Gastric Cancer		COSMIC		PTPN6
245	cs95491	E1737*	-4	PF00041	Intestines Cancer		COSMIC		PTPN6
246	cs86474	P1743S	-1		Lung Cancer	22980975	COSMIC
247	cs51061	S1768L	-2		Skin Cancer(Melanoma)	22622578	COSMIC
248	cs23680	W1771*	-4		Skin Cancer(Melanoma)	22622578	COSMIC
249	cs61669	D1776H	-1		Gastric Cancer		COSMIC
250	cs75331	G1778*	-4		Gastric Cancer		COSMIC
251	cs63102	Q1797H	0		Uterine Cancer		COSMIC
252	cs19860	Q1797*	-4		Renal Cancer	23797736	COSMIC
253	cs68408	N1800T	0		Gastric Cancer		COSMIC
254	cs61804	K1804N	0		Uterine Cancer		COSMIC
255	cs24432	S1810F	-2		Skin Cancer(Melanoma)		COSMIC
256	cs24432	S1810F	-2		Skin Cancer	21984974	COSMIC
257	cs20335	W1817*	-4		Uterine Cancer		COSMIC
258	cs52169	F1826L	0		Intestines Cancer	22810696	COSMIC
259	cs56090	E1840*	-4		Uterine Cancer		COSMIC
260	cs70614	P1858T	-1		Intestines Cancer		COSMIC
261	cs78672	E1859*	-4		Prostate Cancer		COSMIC
262	cs84420	T1865I	-1		Intestines Cancer		COSMIC
263	cs34349	W1882*	-4		Gastric Cancer		COSMIC
264	cs18114	R1884I	-3		Lung Cancer	22980975	COSMIC
265	cs53541	K1887Q	1		Uterine Cancer		COSMIC
266	cs28720	Q1889P	-1		Uterine Cancer		COSMIC
267	cs94009	K1890R	2		Skin Cancer(Melanoma)	24265154	COSMIC
268	cs13490	E1894D	2		Gastric Cancer		COSMIC
269	cs86740	V1896G	-3		Breast Cancer		COSMIC
270	cs93145	N1901K	0		Central Nervous System Neoplasms	22820256	COSMIC
271	cs62259	R1910*	-4		Breast Cancer		COSMIC
272	cs92135	L1928F	0		Intestines Cancer		COSMIC
273	cs38338	E1933K	1		Skin Cancer(Melanoma)		COSMIC
274	cs63179	R1942L	-2		Lung Cancer		COSMIC
275	cs45855	E1943K	1		Skin Cancer(Melanoma)		COSMIC
276	cs46458	L1945P	-3		Intestines Cancer		COSMIC		PTPN6
277	cs40166	L1951M	2	PF00069 PF07714	Uterine Cancer		COSMIC		PTPN6
278	cs91740	Y1960H	2	PF00069 PF07714	Uterine Cancer		COSMIC		PTPN6
279	cs48743	A1964T	0	PF00069 PF07714	Intestines Cancer	22810696	COSMIC		PTPN6
280	cs98222	E1974K	1	PF00069 PF07714	Gastric Cancer		COSMIC		PTPN6
281	cs88513	T1981S	1	PF00069 PF07714	Intestines Cancer		COSMIC		PTPN6
282	cs4456	K2003R	2	PF00069 PF07714	Intestines Cancer	18428421 17344846	COSMIC, Greenman2007		PTPN6
283	cs4456	K2003R	2	PF00069 PF07714	Colorectal Cancer	17344846	HPI		PTPN6
284	cs80383	L2013V	1	PF00069 PF07714	Central Nervous System Neoplasms	23334666	COSMIC		PTPN6
285	cs89544	T2045K	-1	PF00069 PF07714	Lung Cancer		COSMIC		PTPN6
286	cs89544	T2045K	-1	PF00069 PF07714	Prostate Cancer		COSMIC		PTPN6
287	cs94066	F2046Y	3	PF00069 PF07714	Lung Cancer		COSMIC		PTPN6
288	cs55772	G2048D	-1	PF00069 PF07714	Gastric Cancer		COSMIC		PTPN6
289	cs32639	P2049L	-3	PF00069 PF07714	Skin Cancer(Melanoma)		COSMIC		PTPN6
290	cs25796	L2053S	-2	PF00069 PF07714	Uterine Cancer		COSMIC		PTPN6
291	cs62139	G2066C	-3	PF00069 PF07714	Lung Cancer		COSMIC		PTPN6
292	cs69818	C2067G	-3	PF00069 PF07714	Gastric Cancer		COSMIC		PTPN6
293	cs95775	R2072W	-3	PF00069 PF07714	Gastric Cancer		COSMIC		PTPN6
294	cs85412	R2078W	-3	PF00069 PF07714	Lung Cancer		COSMIC		PTPN6
295	cs23827	A2081T	0	PF00069 PF07714	Uterine Cancer		COSMIC		PTPN6
296	cs66088	S2088F	-2	PF00069 PF07714	Skin Cancer(Melanoma)		COSMIC		PTPN6
297	cs62705	Y2092C	-2	PF00069 PF07714	Lung Cancer		COSMIC		PTPN6
298	cs66690	R2096W	-3	PF00069 PF07714	Uterine Cancer		COSMIC		PTPN6
299	cs61271	R2096Q	1	PF00069 PF07714	Gastric Cancer		COSMIC		PTPN6
300	cs76427	A2106T	0	PF00069 PF07714	Ovarian Cancer	21720365	COSMIC		PTPN6
301	cs16787	V2125I	3	PF00069 PF07714	Skin Cancer	21984974	COSMIC		PTPN6
302	cs44237	R2126W	-3	PF00069 PF07714	Skin Cancer(Melanoma)	22622578	COSMIC		PTPN6
303	cs10800	R2126G	-2	PF00069 PF07714	Central Nervous System Neoplasms		COSMIC		PTPN6
304	cs87818	S2132N	1	PF00069 PF07714	Skin Cancer(Melanoma)		COSMIC		PTPN6
305	cs41719	F2138L	0	PF00069 PF07714	Intestines Cancer		COSMIC		PTPN6
306	cs4458	F2138S	-2	PF00069 PF07714	Intestines Cancer		COSMIC		PTPN6
307	cs60365	F2138V	-1	PF00069 PF07714	Intestines Cancer		COSMIC		PTPN6
308	cs4458	F2138S	-2	PF00069 PF07714	Gastric Cancer	18428421 17344846	HPI, COSMIC, Greenman2007		PTPN6
309	cs77469	Q2141H	0	PF00069 PF07714	Gastric Cancer		COSMIC		PTPN6
310	cs97297	V2144I	3	PF00069 PF07714	Lung Cancer		COSMIC		PTPN6
311	cs69991	W2145L	-2	PF00069 PF07714	Uterine Cancer		COSMIC		PTPN6
312	cs32558	I2151F	0	PF00069 PF07714	Lung Cancer	20668451	COSMIC		PTPN6
313	cs42071	L2155F	0	PF00069 PF07714	Skin Cancer(Melanoma)		COSMIC		PTPN6
314	cs42346	G2158S	0	PF00069 PF07714	Prostate Cancer		COSMIC		PTPN6
315	cs51310	E2181K	1	PF00069 PF07714	Skin Cancer(Melanoma)		COSMIC		PTPN6
316	cs50030	R2184K	2	PF00069 PF07714	Intestines Cancer		COSMIC		PTPN6
317	cs53810	R2184I	-3	PF00069 PF07714	Intestines Cancer	23856246	COSMIC		PTPN6
318	cs39563	P2187T	-1	PF00069 PF07714	Lung Cancer	22941188	COSMIC		PTPN6
319	cs38162	D2188G	-1	PF00069 PF07714	Lung Cancer		COSMIC		PTPN6
320	cs43914	D2188H	-1	PF00069 PF07714	Lung Cancer	22980975	COSMIC		PTPN6
321	cs76793	Q2200R	1	PF00069 PF07714	Lymphocytic Leukemia		COSMIC		PTPN6
322	cs12518	E2201*	-4	PF00069 PF07714	Intestines Cancer		COSMIC		PTPN6
323	cs12741	T2207S	1	PF00069 PF07714	Thyroid Carcinoma		COSMIC		PTPN6
324	cs95055	H2209N	1	PF00069 PF07714	Urinary Bladder Cancer		COSMIC		PTPN6
325	cs63257	R2210I	-3	PF00069 PF07714	Intestines Cancer		COSMIC		PTPN6
326	cs60731	R2210*	-4	PF00069 PF07714	Lung Cancer		COSMIC		PTPN6
327	cs32770	D2213N	1	PF07714	Intestines Cancer		COSMIC		PTPN6
328	cs32770	D2213N	1	PF07714	Skin Cancer(Melanoma)	24838835	COSMIC		PTPN6
329	cs32770	D2213N	1	PF07714	Lymphocytic Leukemia		COSMIC		PTPN6
330	cs79263	F2222L	0		Lung Cancer		COSMIC
331	cs55592	K2228Q	1		Intestines Cancer		COSMIC
332	cs55592	K2228Q	1		Lymphocytic Leukemia		COSMIC
333	cs33266	S2229C	-1		Intestines Cancer		COSMIC
334	cs33266	S2229C	-1		Lymphocytic Leukemia		COSMIC
335	cs62719	R2230K	2		Skin Cancer(Melanoma)		COSMIC
336	cs26824	E2232G	-2		Intestines Cancer		COSMIC
337	cs51020	N2234K	0		Breast Cancer		COSMIC
338	cs51020	N2234K	0		Intestines Cancer	22895193	COSMIC
339	cs79785	G2237E	-2		Skin Cancer(Melanoma)		COSMIC
340	cs85242	G2237V	-3		Lung Cancer	22941188	COSMIC
341	cs56682	E2241K	1		Skin Cancer(Melanoma)		COSMIC
342	cs79855	S2242C	-1		Skin Cancer(Melanoma)		COSMIC
343	cs76076	E2244G	-2		Lung Cancer	22941189	COSMIC
344	cs35414	D2247Y	-3		Uterine Cancer		COSMIC
345	cs33548	D2249N	1		Uterine Cancer		COSMIC
346	cs93398	P2260S	-1		Uterine Cancer		COSMIC
347	cs93398	P2260S	-1		Ovarian Cancer		COSMIC
348	cs74942	M2264I	1		Skin Cancer(Melanoma)		COSMIC
349	cs59356	T2266R	-1		Breast Cancer		COSMIC
350	cs25324	N2268T	0		Skin Cancer(Melanoma)		COSMIC
351	cs74085	E2270*	-4		Lung Cancer	22980975	COSMIC
352	cs80084	E2270K	1		Renal Cancer	22138691	COSMIC
353	cs77360	G2271R	-2		Skin Cancer(Melanoma)		COSMIC
354	cs44159	G2271E	-2		Skin Cancer(Melanoma)	22622578	COSMIC
355	cs72490	G2284D	-1		Intestines Cancer	22810696	COSMIC
356	cs63074	K2287T	-1		Esophageal Cancer	23525077	COSMIC
357	cs84353	Q2295H	0		Skin Cancer(Melanoma)		COSMIC
358	cs36663	E2296K	1		Lung Cancer		COSMIC
359	cs36663	E2296K	1		Skin Cancer(Melanoma)		COSMIC
360	cs53327	E2298K	1		Skin Cancer(Melanoma)		COSMIC
361	cs13276	E2308K	1		Skin Cancer(Melanoma)		COSMIC
362	cs78381	E2308Q	2		Renal Cancer		COSMIC
363	cs34961	S2326F	-2		Breast Cancer		COSMIC
364	cs56833	L2337R	-2		Esophageal Cancer	23525077	COSMIC
365	cs91144	Y2342H	2		Intestines Cancer	22810696	COSMIC
366	cs92581	*2348Y	-4		Intestines Cancer	22810696	COSMIC

⁺Conservation of amino acid substitutions are defined here according to the BLOSUM62 matrix, conservative changes were those having a positive or neutral sign in the matrix, whereas non-conservative changes were those having a negative value (Cargill, et al. 1999).
⁺⁺Data sources: HPI, COSMIC, OMIM, TCGA, BIOMART, Greenman2007, Sjoblom2006, Ding2008
*Cross-reference databases: dbSNP
Interface information was collected from Wang 2012

Non-cancer specific variations derived from database dbSNP:

NO.	dbSNP_ID	variation	validated
1	rs34245787	G126V	Cluster
2	rs1998206	T145P	Cluster,Frequency,1000Genome
3	rs180777109	Y164H	1000Genome
4	rs2243380	R167Q	Cluster,Frequency,1000Genome
5	rs142201886	P217T	Cluster
6	rs55959124	P224S	Cluster,Frequency,1000Genome
7	rs189516374	Q291E	1000Genome
8	rs148185831	A320T	Frequency
9	rs146159167	H323N	Frequency
10	rs61743088	G365A	Cluster,Frequency,1000Genome
11	rs56274823	S370P	Cluster,Frequency,1000Genome
12	rs145259410	Y382H	Frequency
13	rs374934137	R448H	Cluster
14	rs41291920	A459S	Frequency,1000Genome
15	rs61729671	K461E	Cluster,Frequency,1000Genome
16	rs140178288	R466Q	Frequency
17	rs28639589	I537M	Cluster,Frequency,1000Genome
18	rs145765584	R560H	Frequency
19	rs142303126	S565L	Frequency
20	rs188607208	S615Y	1000Genome
21	rs151183861	D618G	Cluster,Frequency,1000Genome
22	rs34203286	S653F	Cluster,Frequency,1000Genome
23	rs200174940	V681G	Cluster
24	rs139359697	E698K	Frequency
25	rs141715386	L760I	Cluster,Frequency,1000Genome
26	rs149313880	T776M	Frequency
27	rs34582164	N790S	Cluster,Frequency,1000Genome
28	rs140511382	M792I	Cluster,Frequency,1000Genome
29	rs111621779	V797A	Cluster,Frequency
30	rs199731317	D839E	Cluster
31	rs142979736	R863Q	Frequency
32	rs117865341	A887V	Cluster,Frequency,1000Genome
33	rs115534545	F942L	Cluster,Frequency,1000Genome
34	rs147172890	V946F	Cluster
35	rs191810593	R957S	1000Genome
36	rs139467403	V979A	Frequency
37	rs200278757	P1010T	Cluster
38	rs200278757	P1010S	Cluster
39	rs141171688	Y1011C	Cluster,1000Genome
40	rs143148482	K1026M	Cluster,Frequency,1000Genome
41	rs149513638	G1027D	Frequency
42	rs61729673	G1077E	Cluster,Frequency
43	rs193271148	I1084V	1000Genome
44	rs115286894	N1095I	Cluster,Frequency,1000Genome
45	rs2229079	S1109L	Cluster,Frequency,1000Genome
46	rs151330473	G1135R	Cluster
47	rs35302901	L1209*	Cluster,Frequency
48	rs56192249	Y1239F	Cluster,1000Genome
49	rs35269727	Y1353S	Cluster
50	rs36106063	C1370R	Cluster
51	rs183156700	T1384P	1000Genome
52	rs17079086	F1439S	Cluster,Frequency,1000Genome
53	rs35841892	R1506G	Cluster,Frequency,1000Genome
54	rs112739824	P1522Q	Cluster,Frequency
55	rs150147295	I1549V	1000Genome
56	rs150852319	V1557I	Cluster,Frequency
57	rs199762082	R1569W	Cluster
58	rs192730088	S1570P	1000Genome
59	rs45439298	A1601D	Cluster,Frequency,1000Genome
60	rs146668165	L1620F	Cluster,1000Genome
61	rs142109327	S1626F	Cluster,Frequency,1000Genome
62	rs147104879	C1638Y	Cluster,Frequency
63	rs184429367	P1659T	1000Genome
64	rs140772370	Q1692R	Frequency
65	rs143435239	S1739R	Frequency
66	rs12664076	D1776H	Cluster,Frequency,1000Genome,HapMap
67	rs192321490	D1854E	1000Genome
68	rs147114498	P1877S	Cluster,Frequency
69	rs147114498	P1877T	Cluster,Frequency
70	rs144529412	K1890E	Cluster,Frequency,1000Genome
71	rs9489124	E1902K	Cluster,Frequency,1000Genome
72	rs144955662	H1926Y	Cluster,Frequency
73	rs144955662	H1926D	Cluster,Frequency
74	rs138420858	Y1960C	1000Genome
75	rs145889490	V1977A	Cluster,1000Genome
76	rs139620900	Q1989H	Frequency
77	rs45569132	H1999N	Cluster
78	rs3752566	R2039H	Cluster,Frequency,1000Genome
79	rs201894511	V2054I	Cluster
80	rs193121244	I2063N	1000Genome
81	rs147454452	R2078S	Cluster
82	rs150994413	Y2115C	1000Genome
83	rs182529844	Y2173N	1000Genome
84	rs140284927	T2195S	Frequency
85	rs145104466	R2205I	Cluster,Frequency
86	rs149949391	T2207A	Cluster
87	rs148104006	R2210T	Cluster,Frequency,1000Genome
88	rs529038	D2213H	Cluster,Frequency,1000Genome
89	rs529038	D2213N	Cluster,Frequency,1000Genome
90	rs529156	K2228Q	Cluster,Frequency,1000Genome
91	rs619203	S2229C	Cluster,Frequency,1000Genome
92	rs210968	N2240K	Cluster,Frequency,1000Genome
93	rs148710046	G2245D	Cluster,Frequency
94	rs149630222	E2265D	Frequency
95	rs183984056	T2279I	1000Genome
96	rs41291918	G2282D	Cluster
97	rs35932630	K2328R	Cluster,Frequency,1000Genome
98	rs143434059	P2329A	Cluster,Frequency,1000Genome

Cancer-related differential expression proteins derived from database dbDEPC:

No entry in dbDEPC was found

[ continue search ]