ID you entered:  ENSP00000357615

Ensembl protein: ENSP00000357615   

          Protein sequence 
Name: FRK
Description: fyn-related kinase [Source:HGNC Symbol;Acc:3955]
Location:
            chr6 q22.1
Gene Ontology:
           Biological process 
           Molecular function 
           Cellular localization 
Interactions:   
          Interaction partner with cancer_related variations :  (  pvalue=0.274799, hypergeometric test )
                 4 
          Interaction partner with cancer related differentially expressed proteins :    NA
                         

  • Cancer-related variations in CanProVar:
    • NO.csIDvariationchange conservation+Domaincancer namePubMeddata source++validated dbSNP*interface
    1cs2485Y193*-4PF00017  Lung Cancer18428421  16140923  17344846   Greenman2007
    2cs8771R406H0PF00069  PF07714  Lung Cancer21930502  21930507  18948947   Ding2008, BIOMART

    +Conservation of amino acid substitutions are defined here according to the BLOSUM62 matrix, conservative changes were those having a positive or neutral sign in the matrix, whereas non-conservative changes were those having a negative value (Cargill, et al. 1999).
    ++Data sources:  HPI,  COSMIC,  OMIM,  TCGA,  BIOMART,  Greenman2007,  Sjoblom2006,  Ding2008
    *Cross-reference databases: dbSNP
    Interface information was collected from Wang 2012


  • Non-cancer specific variations derived from database dbSNP:

    • NO.dbSNP_IDvariationvalidated
    1rs148022890Y99FCluster,Frequency,1000Genome
    2rs34704018I100VCluster,Frequency
    3rs142770112G119AFrequency
    4rs3756772G122RHapMap,1000Genome,Cluster,Frequency
    5rs117605537D125EFrequency,1000Genome
    6rs34064900S133LCluster,Frequency,1000Genome
    7rs143351471V161ICluster,Frequency,1000Genome
    8rs190975105T178M1000Genome
    9rs148594761V202L1000Genome
    10rs146859190N272S1000Genome
    11rs190064484R348Q1000Genome
    12rs146191498V362ACluster,Frequency,1000Genome
    13rs185354663E392K1000Genome
    14rs149341971I393RFrequency
    15rs12209851R451KCluster,Frequency
    16rs150528750E481V1000Genome
    17rs141525046R484H1000Genome


  • Cancer-related differential expression proteins derived from database dbDEPC:


    • No entry in dbDEPC was found



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