ID you entered:  ENSP00000377969

Ensembl protein: ENSP00000377969   

          Protein sequence 
Name: GTF2F1
Description: general transcription factor IIF, polypeptide 1, 74kDa [Source:HGNC Symbol;Acc:HGNC:4652]
Location:
            chr19 p13.3
Gene Ontology:
           Biological process 
           Molecular function 
           Cellular localization 
Interactions:   
          Interaction partner with cancer_related variations :  (  pvalue=0.100357, hypergeometric test )
                 35 
          Interaction partner with cancer related differentially expressed proteins :    NA
                         

  • Cancer-related variations in CanProVar:
    • NO.csIDvariationchange conservation+Domaincancer namePubMeddata source++validated dbSNP*interface
    1cs29664E259K1PF05793  Breast Cancer21930502  21930507   BIOMARTGTF2F2, CTDP1

    +Conservation of amino acid substitutions are defined here according to the BLOSUM62 matrix, conservative changes were those having a positive or neutral sign in the matrix, whereas non-conservative changes were those having a negative value (Cargill, et al. 1999).
    ++Data sources:  HPI,  COSMIC,  OMIM,  TCGA,  BIOMART,  Greenman2007,  Sjoblom2006,  Ding2008
    *Cross-reference databases: dbSNP
    Interface information was collected from Wang 2012


  • Non-cancer specific variations derived from database dbSNP:

    • NO.dbSNP_IDvariationvalidated
    1rs34826931A3VCluster,Frequency
    2rs150462935P6LFrequency
    3rs140541374S7GFrequency
    4rs151336104S7RFrequency
    5rs148541576V87IFrequency
    6rs188082753L100F1000Genome
    7rs75905892K105TCluster
    8rs78502158K105*Cluster
    9rs141810642V118IFrequency
    10rs142604322R206CFrequency
    11rs142704916F266LCluster,1000Genome
    12rs143977043R386CFrequency
    13rs190305979R413W1000Genome
    14rs73563878S436LCluster,Frequency,1000Genome
    15rs149599017R499Q1000Genome


  • Cancer-related differential expression proteins derived from database dbDEPC:


    • No entry in dbDEPC was found



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