ID you entered:  ENSP00000384275

Ensembl protein: ENSP00000384275   

          Protein sequence 
Name: STK11
Description: serine/threonine kinase 11 [Source:HGNC Symbol;Acc:11389]
Location:
            chr19 p13.3
Gene Ontology:
           Biological process 
           Molecular function 
           Cellular localization 
Interactions:   
          Interaction partner with cancer_related variations :  (  pvalue=0.000619436, hypergeometric test )
                 35 
          Interaction partner with cancer related differentially expressed proteins :    NA
                         

  • Cancer-related variations in CanProVar:
    • NO.csIDvariationchange conservation+Domaincancer namePubMeddata source++validated dbSNP*interface
    1cs977Q37*-4Lung Cancer18428421  15021901  12097271  18948947  
    17711506  16140923  17344846      		 Ding2008, Greenman2007
    2cs8647Q37L-2Lung Cancer18948947   Ding2008
    3cs8640G56W-2PF00069  PF07714  Lung Cancer18948947   Ding2008RPS6KA3, CAB39, RPS6KB1,
    4cs951Y60*-4PF00069  PF07714  Lung Cancer18428421  15077168  18948947   Ding2008RPS6KA3, CAB39, RPS6KB1,
    5cs8643K78E1PF00069  PF07714  Lung Cancer18948947   Ding2008RPS6KA3, CAB39, RPS6KB1,
    6cs942R87K2PF00069  PF07714  Skin Cancer18428421  17344846   Greenman2007RPS6KA3, CAB39, RPS6KB1,
    7cs8646G91L-4PF00069  PF07714  Lung Cancer18948947   Ding2008RPS6KA3, CAB39, RPS6KB1,
    8cs8637Q137*-4PF00069  PF07714  Lung Cancer18948947   Ding2008RPS6KA3, CAB39, RPS6KB1,
    9cs980Q159*-4PF00069  PF07714  Lung Cancer18428421  18594528  18948947   Ding2008RPS6KA3, CAB39, RPS6KB1,
    10cs8642E165*-4PF00069  PF07714  Lung Cancer18948947   Ding2008RPS6KA3, CAB39, RPS6KB1,
    11cs970Q170*-4PF00069  PF07714  Lung Cancer18428421  18549475  10208439  18948947   Ding2008RPS6KA3, CAB39, RPS6KB1,
    12cs970Q170*-4PF00069  PF07714  Skin Cancer18428421  18549475  10208439  18948947   Ding2008RPS6KA3, CAB39, RPS6KB1,
    13cs8644K191*-4PF00069  PF07714  Lung Cancer18948947   Ding2008RPS6KA3, CAB39, RPS6KB1,
    14cs8645G196V-3PF00069  PF07714  Lung Cancer18948947   Ding2008RPS6KA3, CAB39, RPS6KB1,
    15cs936E199*-4PF00069  PF07714  Lung Cancer18428421  18948947   Ding2008RPS6KA3, CAB39, RPS6KB1,
    16cs974Q220*-4PF00069  PF07714  Uterine Cancer18428421  18948947   Ding2008RPS6KA3, CAB39, RPS6KB1,
    17cs974Q220*-4PF00069  PF07714  Lung Cancer18428421  18948947   Ding2008RPS6KA3, CAB39, RPS6KB1,
    18cs8641D237Y-3PF00069  PF07714  Lung Cancer18948947   Ding2008RPS6KA3, CAB39, RPS6KB1,
    19cs8638G242V-3PF00069  PF07714  Lung Cancer18948947   Ding2008RPS6KA3, CAB39, RPS6KB1,
    20cs8648R304G-2PF00069  PF07714  Lung Cancer18948947   Ding2008RPS6KA3, CAB39, RPS6KB1,
    21cs8639A389T0Lung Cancer18948947   Ding2008

    +Conservation of amino acid substitutions are defined here according to the BLOSUM62 matrix, conservative changes were those having a positive or neutral sign in the matrix, whereas non-conservative changes were those having a negative value (Cargill, et al. 1999).
    ++Data sources:  HPI,  COSMIC,  OMIM,  TCGA,  BIOMART,  Greenman2007,  Sjoblom2006,  Ding2008
    *Cross-reference databases: dbSNP
    Interface information was collected from Wang 2012


  • Non-cancer specific variations derived from database dbSNP:

    • NO.dbSNP_IDvariationvalidated
    1rs148830698R42Q1000Genome
    2rs121913323Q170*Cluster
    3rs121913315D194NCluster
    4rs121913315D194YCluster
    5rs185087320R211W1000Genome
    6rs121913322P281LCluster,1000Genome
    7rs59912467F354LCluster,Frequency,1000Genome


  • Cancer-related differential expression proteins derived from database dbDEPC:


    • No entry in dbDEPC was found



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