ID you entered:  ENSP00000414062

Ensembl protein: ENSP00000414062   

          Protein sequence 
Name: ABCA7
Description: ATP-binding cassette, sub-family A (ABC1), member 7 [Source:HGNC Symbol;Acc:HGNC:37]
Location:
            chr19 p13.3
Gene Ontology:
           Biological process 
           Molecular function 
           Cellular localization 
Interactions:   
          Interaction partner with cancer_related variations :  (  pvalue=0.724056, hypergeometric test )
                 1 
          Interaction partner with cancer related differentially expressed proteins :    NA
                         

  • Cancer-related variations in CanProVar:
    • NO.csIDvariationchange conservation+Domaincancer namePubMeddata source++validated dbSNP*interface
    1cs90301M153I1Ovarian Cancer18772890  21720365   TCGA
    2cs49437R286C-3Neoplasms by Histologic Type21930502  21930507   BIOMART

    +Conservation of amino acid substitutions are defined here according to the BLOSUM62 matrix, conservative changes were those having a positive or neutral sign in the matrix, whereas non-conservative changes were those having a negative value (Cargill, et al. 1999).
    ++Data sources:  HPI,  COSMIC,  OMIM,  TCGA,  BIOMART,  Greenman2007,  Sjoblom2006,  Ding2008
    *Cross-reference databases: dbSNP
    Interface information was collected from Wang 2012


  • Non-cancer specific variations derived from database dbSNP:

    • NO.dbSNP_IDvariationvalidated
    1rs199776416N58KCluster
    2rs148580487P68AFrequency
    3rs146597357L85MFrequency
    4rs151054304P152LCluster,Frequency,1000Genome
    5rs3764645E188GCluster,Frequency,1000Genome,HapMap
    6rs138777686L190VFrequency
    7rs142809982A196VFrequency
    8rs72973581G215SCluster,Frequency,1000Genome
    9rs150820818S231NFrequency
    10rs77403558R285*Cluster,Frequency
    11rs3752232T319ACluster,Frequency,1000Genome
    12rs146086314R334WFrequency
    13rs143296441M354TCluster,1000Genome
    14rs146982710P364RFrequency
    15rs3764647H395RCluster,Frequency,1000Genome
    16rs10405305A414GCluster,Frequency,1000Genome
    17rs150867671R433QCluster,Frequency,1000Genome
    18rs3752233R463HCluster,Frequency,1000Genome
    19rs142700284P492TFrequency
    20rs200770980V499M1000Genome
    21rs144979723A589VFrequency
    22rs138819755L591PFrequency
    23rs144852598L620PFrequency
    24rs140710007F635L1000Genome
    25rs145232000S647LCluster,1000Genome
    26rs59851484A676TCluster,Frequency,1000Genome
    27rs3752239N718TCluster,Frequency,1000Genome
    28rs76282929Q758HCluster,Frequency,1000Genome
    29rs149949633G776RFrequency
    30rs199517653G826RCluster
    31rs149652747T849NFrequency
    32rs139251928D871HFrequency
    33rs74176364A877TCluster,Frequency,1000Genome
    34rs139415355A878TCluster
    35rs143718918R880QCluster,Frequency,1000Genome
    36rs111940546A914SCluster,Frequency
    37rs146448899Q959*Cluster,Frequency
    38rs139214131R989HFrequency
    39rs143226982T990MFrequency
    40rs141322593R1026CFrequency
    41rs150012110G1111SFrequency
    42rs139615270L1116F1000Genome
    43rs147086830R1177QFrequency
    44rs142601420P1181L1000Genome
    45rs148143428G1190RCluster,Frequency
    46rs150557489A1223T1000Genome
    47rs114614802R1237HFrequency,1000Genome
    48rs138363826V1244MFrequency
    49rs3745842R1349QHapMap,1000Genome,Cluster,Frequency
    50rs139467472G1351SCluster,Frequency,1000Genome
    51rs144595576R1385QFrequency
    52rs112719199F1390LCluster,Frequency
    53rs145667385R1397CFrequency
    54rs145321888R1400HFrequency
    55rs149196228K1407RCluster,Frequency,1000Genome
    56rs140313804G1421VFrequency
    57rs145232000S1428LCluster,1000Genome
    58rs142617105A1441VCluster
    59rs138567176G1448DFrequency
    60rs144562001R1453GCluster,Frequency,1000Genome
    61rs144562001R1453CCluster,Frequency,1000Genome
    62rs151112873R1489QFrequency
    63rs201941781A1493TCluster
    64rs141113429R1496HCluster
    65rs149824618G1502VFrequency
    66rs113269196R1505HCluster,Frequency,1000Genome
    67rs192694824A1507T1000Genome
    68rs3752246G1527ACluster,Frequency,1000Genome,HapMap
    69rs140816246V1538IFrequency
    70rs145632609C1541Y1000Genome
    71rs187233122L1581F1000Genome
    72rs117187003V1599MCluster,Frequency,1000Genome
    73rs184590335S1629L1000Genome
    74rs143083561P1632LFrequency
    75rs141237099V1643MCluster,1000Genome
    76rs187637927S1645R1000Genome
    77rs4147918Q1686RCluster,Frequency,1000Genome
    78rs184218896I1690T1000Genome
    79rs142462701R1715HFrequency
    80rs146448899Q1722*Cluster,Frequency
    81rs73505232S1723LCluster,Frequency,1000Genome
    82rs188971580G1731S1000Genome
    83rs200364821R1764QCluster
    84rs139765732G1770ECluster,Frequency,1000Genome
    85rs145071620E1774K1000Genome
    86rs147558402R1778H1000Genome
    87rs148891749R1780WFrequency
    88rs114782266R1812HCluster,Frequency,1000Genome
    89rs189602802A1919S1000Genome
    90rs114787084R1932CCluster,Frequency,1000Genome
    91rs142573667C1988F1000Genome
    92rs4147934A2045SCluster,Frequency,1000Genome
    93rs190013803F2071C1000Genome
    94rs139706726E2108K1000Genome


  • Cancer-related differential expression proteins derived from database dbDEPC:


    • No entry in dbDEPC was found



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