ID you entered:  ENSP00000443574

Ensembl protein: ENSP00000443574   

          Protein sequence 
Name: ATP8B3
Description: ATPase, aminophospholipid transporter, class I, type 8B, member 3 [Source:HGNC Symbol;Acc:13535]
Location:
            chr19 p13.3
Gene Ontology:
           Biological process 
           Molecular function 
           Cellular localization 
Interactions:   
          Interaction partner with cancer_related variations :  (  pvalue=0.724056, hypergeometric test )
                 1 
          Interaction partner with cancer related differentially expressed proteins :    NA
                         

  • Cancer-related variations in CanProVar:
    • NO.csIDvariationchange conservation+Domaincancer namePubMeddata source++validated dbSNP*interface
    1cs47734G774R-2PF00702  Head and Neck Cancer21798893   COSMIC
    2cs34190H1250Y2Ovarian Cancer21720365   COSMIC

    +Conservation of amino acid substitutions are defined here according to the BLOSUM62 matrix, conservative changes were those having a positive or neutral sign in the matrix, whereas non-conservative changes were those having a negative value (Cargill, et al. 1999).
    ++Data sources:  HPI,  COSMIC,  OMIM,  TCGA,  BIOMART,  Greenman2007,  Sjoblom2006,  Ding2008
    *Cross-reference databases: dbSNP
    Interface information was collected from Wang 2012


  • Non-cancer specific variations derived from database dbSNP:

    • NO.dbSNP_IDvariationvalidated
    1rs7250872G45RHapMap,1000Genome,Cluster,Frequency
    2rs141216755I170-1000Genome
    3rs45574836A213TCluster,Frequency,1000Genome
    4rs186171636V249I1000Genome
    5rs142875994N333S1000Genome
    6rs185527103G399S1000Genome
    7rs115821228A424T1000Genome
    8rs8100856V618ICluster,Frequency,1000Genome
    9rs145805623R641C1000Genome
    10rs182855776R669C1000Genome
    11rs185225335R724W1000Genome
    12rs186722296E801K1000Genome
    13rs140363712S813G1000Genome
    14rs191598401R875L1000Genome
    15rs187141822D1081E1000Genome
    16rs16994563V1179ICluster,Frequency,1000Genome
    17rs183931951V1193M1000Genome
    18rs116586018P1249L1000Genome
    19rs143042487R1256H1000Genome
    20rs12461709H1266PHapMap
    21rs78153786R1267HCluster,Frequency,1000Genome
    22rs16994559N1272HCluster,Frequency,1000Genome


  • Cancer-related differential expression proteins derived from database dbDEPC:


    • No entry in dbDEPC was found



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