ID you entered:  ENSP00000078429

Ensembl protein: ENSP00000078429   

          Protein sequence 
Name: GNA11
Description: guanine nucleotide binding protein (G protein), alpha 11 (Gq class) [Source:HGNC Symbol;Acc:HGNC:4379]
Location:
            chr19 p13.3
Gene Ontology:
           Biological process 
           Molecular function 
           Cellular localization 
Interactions:   
          Interaction partner with cancer_related variations :  (  pvalue=0.120134, hypergeometric test )
                 13 
          Interaction partner with cancer related differentially expressed proteins :    NA
                         

  • Cancer-related variations in CanProVar:
    • NO.csIDvariationchange conservation+Domaincancer namePubMeddata source++validated dbSNP*interface
    1cs60200R30W-3PF00503  Urinary Bladder Cancer COSMIC
    2cs81378I56V3PF00503  Intestines Cancer22895193   COSMIC
    3cs65411K57Q1PF00503  Gastric Cancer COSMIC
    4cs23039G66S0PF00503  Intestines Cancer COSMIC
    5cs94419R114W-3PF00503  Breast Cancer COSMIC
    6cs50168I132M1PF00503  Lung Cancer COSMIC
    7cs78604I132V3PF00503  Lung Cancer COSMIC
    8cs58814L135P-3PF00503  Gastric Cancer COSMIC
    9cs58362R147H0PF00503  Renal Cancer COSMIC
    10cs81483V164I3PF00503  Intestines Cancer COSMIC
    11cs54745V164G-3PF00503  Intestines Cancer22895193   COSMIC
    12cs10729R183L-2PF00025  PF00503  Intestines Cancer COSMIC
    13cs3623R183C-3PF00025  PF00503  Skin Cancer(Melanoma)23778528  23572068  23887304  24423917  
    22842228  21083380      		 COSMIC
    14cs3623R183C-3PF00025  PF00503  Melanoma COSMIC
    15cs98252R183H0PF00025  PF00503  Skin Cancer21083380   COSMIC
    16cs92974M203L2PF00025  PF00503  Skin Cancer(Melanoma) COSMIC
    17cs42611Q209K1PF00025  PF00503  Prostate Cancer22722839   COSMIC
    18cs11381Q209L-2PF00025  PF00503  Cancer21083380   COSMIC
    19cs90047Q209H0PF00025  PF00503  Head and Neck Cancer24633157   COSMIC
    20cs52362Q209P-1PF00025  PF00503  Brain Cancer22307269   COSMIC
    21cs11381Q209L-2PF00025  PF00503  Skin Cancer(Melanoma)24714776  22236444  23778528  23456173  
    23887304  22977135  23861464  
    23634288  22817889  22842228  
    22569040  21874003  23793026  
    21083380  22515704  23934701  
    24423917  22758774  23464620      		 COSMIC
    22cs11381Q209L-2PF00025  PF00503  Skin Cancer21083380  23599145  23261261   COSMIC
    23cs95645Q209*-4PF00025  PF00503  Intestines Cancer COSMIC
    24cs52362Q209P-1PF00025  PF00503  Skin Cancer(Melanoma)21083380  22977135  23778528   COSMIC
    25cs11381Q209L-2PF00025  PF00503  Brain Cancer22421249  22758774   COSMIC
    26cs41110Q209R1PF00025  PF00503  Skin Cancer(Melanoma)23934701   COSMIC
    27cs11381Q209L-2PF00025  PF00503  Head and Neck Cancer21874003   COSMIC
    28cs36388R214M-1PF00025  PF00503  Skin Cancer(Melanoma)23778528   COSMIC
    29cs45204E221Q2PF00025  PF00503  Breast Cancer COSMIC
    30cs51735V223A0PF00025  PF00503  Intestines Cancer COSMIC
    31cs60099V223M1PF00025  PF00503  Skin Cancer(Melanoma)20424519   COSMIC
    32cs60099V223M1PF00025  PF00503  Melanoma20424519   COSMIC
    33cs66905Y235*-4PF00025  PF00503  Ovarian Cancer21720365   COSMIC
    34cs3622R256W-3PF00025  PF00503  Skin Cancer(Melanoma) COSMIC
    35cs3622R256W-3PF00025  PF00503  Melanoma COSMIC
    36cs20989N266K0PF00025  PF00503  Melanoma20424519   COSMIC
    37cs20989N266K0PF00025  PF00503  Skin Cancer(Melanoma)20424519   COSMIC
    38cs46605S268A1PF00025  PF00503  Gastric Cancer COSMIC
    39cs46661V269I3PF00025  PF00503  Gastric Cancer COSMIC
    40cs12561S286L-2PF00503  Gastric Cancer22484628   COSMIC
    41cs23068F292V-1PF00503  Ovarian Cancer COSMIC
    42cs52923P293S-1PF00503  Skin Cancer(Melanoma) COSMIC
    43cs61354E294*-4PF00503  Breast Cancer COSMIC
    44cs58224R306L-2PF00503  Lung Cancer COSMIC
    45cs78511H327R0PF00503  Skin Cancer(Melanoma) COSMIC
    46cs40650D333N1PF00503  Uterine Cancer COSMIC
    47cs83619D333Y-3PF00503  Melanoma20424519   COSMIC
    48cs83619D333Y-3PF00503  Skin Cancer(Melanoma)20424519   COSMIC
    49cs80803V344M1PF00503  Uterine Cancer COSMIC
    50cs42474L351P-3PF00503  Gastric Cancer COSMIC

    +Conservation of amino acid substitutions are defined here according to the BLOSUM62 matrix, conservative changes were those having a positive or neutral sign in the matrix, whereas non-conservative changes were those having a negative value (Cargill, et al. 1999).
    ++Data sources:  HPI,  COSMIC,  OMIM,  TCGA,  BIOMART,  Greenman2007,  Sjoblom2006,  Ding2008
    *Cross-reference databases: dbSNP
    Interface information was collected from Wang 2012


  • Non-cancer specific variations derived from database dbSNP:

    • NO.dbSNP_IDvariationvalidated
    1rs147528229A65TCluster,Frequency,1000Genome
    2rs74913870F84SCluster
    3rs191421665L170M1000Genome


  • Cancer-related differential expression proteins derived from database dbDEPC:


    • No entry in dbDEPC was found



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