ID you entered:  ENSP00000159111

Ensembl protein: ENSP00000159111   

          Protein sequence 
Name: KDM4B
Description: lysine (K)-specific demethylase 4B [Source:HGNC Symbol;Acc:HGNC:29136]
Location:
            chr19 p13.3
Gene Ontology:
           Biological process 
           Molecular function 
           Cellular localization 
Interactions:   
          Interaction partner with cancer_related variations :  (  pvalue=0.263157, hypergeometric test )
                 7 
          Interaction partner with cancer related differentially expressed proteins :    NA
                         

  • Cancer-related variations in CanProVar:
    • NO.csIDvariationchange conservation+Domaincancer namePubMeddata source++validated dbSNP*interface
    1cs18910Q85R1Hepatocellular Carcinoma21822264   COSMIC
    2cs31474P527S-1Skin Cancer21984974   COSMIC
    3cs11890E741K1Lung Cancer COSMIC
    4cs11176S978F-2Skin Cancer21984974   COSMIC
    5cs31312A1057D-2Head and Neck Cancer21984974   COSMIC

    +Conservation of amino acid substitutions are defined here according to the BLOSUM62 matrix, conservative changes were those having a positive or neutral sign in the matrix, whereas non-conservative changes were those having a negative value (Cargill, et al. 1999).
    ++Data sources:  HPI,  COSMIC,  OMIM,  TCGA,  BIOMART,  Greenman2007,  Sjoblom2006,  Ding2008
    *Cross-reference databases: dbSNP
    Interface information was collected from Wang 2012


  • Non-cancer specific variations derived from database dbSNP:

    • NO.dbSNP_IDvariationvalidated
    1rs188792784C13S1000Genome
    2rs11667206N29TCluster,Frequency,HapMap
    3rs200637487L201P1000Genome
    4rs138157752E264VFrequency
    5rs191502470K381T1000Genome
    6rs147027017E419-1000Genome
    7rs143126120R454QCluster
    8rs139154297V531MCluster,1000Genome
    9rs200691572A555VCluster
    10rs185663539A578V1000Genome
    11rs144327370A578PFrequency
    12rs148763203R584CFrequency
    13rs142412728P597LFrequency
    14rs143239564D953NFrequency
    15rs148375932R1020CCluster
    16rs202201915A1049SCluster
    17rs183777321G1073R1000Genome
    18rs200297667R1074QCluster


  • Cancer-related differential expression proteins derived from database dbDEPC:


    • No entry in dbDEPC was found



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