ID you entered:  ENSP00000222033

Ensembl protein: ENSP00000222033   

          Protein sequence 
Name: ZNRF4
Description: zinc and ring finger 4 [Source:HGNC Symbol;Acc:HGNC:17726]
Location:
            chr19 p13.3
Gene Ontology:
           Biological process 
           Molecular function 
           Cellular localization 
Interactions:   
          Interaction partner with cancer_related variations :  (  pvalue=0.286061, hypergeometric test )
                 7 
          Interaction partner with cancer related differentially expressed proteins :    NA
                         

  • Cancer-related variations in CanProVar:
    • NO.csIDvariationchange conservation+Domaincancer namePubMeddata source++validated dbSNP*interface
    1cs12624A208T0PF02225  Head and Neck Cancer21798893   COSMIC
    2cs86003D239N1Skin Cancer21984974   COSMIC
    3cs57622V350M1PF00097  Intestines Cancer17932254   COSMIC
    4cs71496P377Q-1Intestines Cancer17932254   COSMIC

    +Conservation of amino acid substitutions are defined here according to the BLOSUM62 matrix, conservative changes were those having a positive or neutral sign in the matrix, whereas non-conservative changes were those having a negative value (Cargill, et al. 1999).
    ++Data sources:  HPI,  COSMIC,  OMIM,  TCGA,  BIOMART,  Greenman2007,  Sjoblom2006,  Ding2008
    *Cross-reference databases: dbSNP
    Interface information was collected from Wang 2012


  • Non-cancer specific variations derived from database dbSNP:

    • NO.dbSNP_IDvariationvalidated
    1rs78645830R5CCluster,1000Genome
    2rs144624511S14T1000Genome
    3rs200586901A20VCluster
    4rs2240743P37SCluster,Frequency,1000Genome
    5rs199689222W73GCluster
    6rs2240744R78QCluster,Frequency,1000Genome,HapMap
    7rs2240745V100ICluster,Frequency,1000Genome,HapMap
    8rs141487677R101Q1000Genome
    9rs149951234A118V1000Genome
    10rs61740899R130G1000Genome
    11rs182381348E146K1000Genome
    12rs8103406A157SCluster,Frequency,1000Genome
    13rs8107825V159ACluster,Frequency,1000Genome
    14rs17304380R163HCluster,Frequency,1000Genome
    15rs8104246R163CHapMap,1000Genome,Cluster,Frequency
    16rs187068340G179S1000Genome
    17rs16992985D192NCluster,Frequency
    18rs114216623V214M1000Genome
    19rs145022317R300H1000Genome
    20rs199505275R380QCluster


  • Cancer-related differential expression proteins derived from database dbDEPC:


    • No entry in dbDEPC was found



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