ID you entered:  ENSP00000233607

Ensembl protein: ENSP00000233607   

          Protein sequence 
Name: APC2
Description: adenomatosis polyposis coli 2 [Source:HGNC Symbol;Acc:HGNC:24036]
Location:
            chr19 p13.3
Gene Ontology:
           Biological process 
           Molecular function 
           Cellular localization 
Interactions:   
          Interaction partner with cancer_related variations :  (  pvalue=0.147757, hypergeometric test )
                 23 
          Interaction partner with cancer related differentially expressed proteins :  (  pvalue=0.000003647, hypergeometric test )
                 18 
                         

  • Cancer-related variations in CanProVar:
    • NO.csIDvariationchange conservation+Domaincancer namePubMeddata source++validated dbSNP*interface
    1cs8075I377M1Breast Cancer COSMIC
    2cs8076A562S1Breast Cancer16959974   HPI, COSMIC, Sjoblom2006
    3cs49868H941Q0Pancreatic Cancer COSMIC
    4cs8077G2003S0PF05956  Breast Cancer16959974   HPI, COSMIC, Sjoblom2006

    +Conservation of amino acid substitutions are defined here according to the BLOSUM62 matrix, conservative changes were those having a positive or neutral sign in the matrix, whereas non-conservative changes were those having a negative value (Cargill, et al. 1999).
    ++Data sources:  HPI,  COSMIC,  OMIM,  TCGA,  BIOMART,  Greenman2007,  Sjoblom2006,  Ding2008
    *Cross-reference databases: dbSNP
    Interface information was collected from Wang 2012


  • Non-cancer specific variations derived from database dbSNP:

    • NO.dbSNP_IDvariationvalidated
    1rs139475598G45ACluster,1000Genome
    2rs144391493T70MFrequency
    3rs201679326S85RCluster
    4rs150959468G112S1000Genome
    5rs143295265F140SCluster,Frequency,1000Genome
    6rs146579468P266TFrequency
    7rs143870588G323R1000Genome
    8rs188279084Q410R1000Genome
    9rs146114138R429HFrequency
    10rs185503053R455Q1000Genome
    11rs150518571V478I1000Genome
    12rs139596517R487HFrequency
    13rs35991061G489SCluster
    14rs143631108A577TCluster
    15rs150888374S599NCluster
    16rs193036016A829V1000Genome
    17rs201308289S921GCluster
    18rs61735597A949TCluster,1000Genome
    19rs189432097Q1000K1000Genome
    20rs145292370P1015L1000Genome
    21rs181829726A1017G1000Genome
    22rs137877386A1219V1000Genome
    23rs142307435T1227I1000Genome
    24rs116169601R1456PFrequency,1000Genome
    25rs202171992A1505TCluster
    26rs73516821P1799LCluster,1000Genome
    27rs166453A2024VFrequency,1000Genome
    28rs189440287A2057T1000Genome
    29rs166452T2077SCluster,1000Genome
    30rs77359769P2081LCluster
    31rs265277S2241ACluster,Frequency,1000Genome


  • Cancer-related differential expression proteins derived from database dbDEPC:

    • NO.dbDEPC_IDchangeratiocancer namedesignsample_controlsample_casesamplepubmed
    1EXP000158.4Gastric CancerMetastasisthe noninvasive gastric cancer SC-M1 cellthe metastatic gastric cancer TMC-1 cellscell line17022644  
    2EXP001868.4Gastric CancerMetastasisthe noninvasive gastric cancer SC-M1 cell(a well-established human gastric carcinoma cell line, originally cultured from a poorly differentiated adenocarcinoma that invaded through the stomach wall but showed no metastasis to lymph nodes or adjacent organs)the metastatic gastric cancer TMC-1 cells(derived from the lymph node of an individual with a moderately differentiated adenocarcinoma of the stomach and exhibited highly tumorigenic features)cell line17022644  



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