ID you entered:  ENSP00000234347

Ensembl protein: ENSP00000234347   

          Protein sequence 
Name: PRTN3
Description: proteinase 3 [Source:HGNC Symbol;Acc:HGNC:9495]
Location:
            chr19 p13.3
Gene Ontology:
           Biological process 
           Molecular function 
           Cellular localization 
Interactions:   
          Interaction partner with cancer_related variations :  (  pvalue=0.263157, hypergeometric test )
                 7 
          Interaction partner with cancer related differentially expressed proteins :  (  pvalue=0.0328366, hypergeometric test )
                 5 
                         

  • Cancer-related variations in CanProVar:
    • NO.csIDvariationchange conservation+Domaincancer namePubMeddata source++validated dbSNP*interface
    1cs35124Q78R1PF09342  PF00089  Ovarian Cancer21720365   COSMICSERPINB1

    +Conservation of amino acid substitutions are defined here according to the BLOSUM62 matrix, conservative changes were those having a positive or neutral sign in the matrix, whereas non-conservative changes were those having a negative value (Cargill, et al. 1999).
    ++Data sources:  HPI,  COSMIC,  OMIM,  TCGA,  BIOMART,  Greenman2007,  Sjoblom2006,  Ding2008
    *Cross-reference databases: dbSNP
    Interface information was collected from Wang 2012


  • Non-cancer specific variations derived from database dbSNP:

    • NO.dbSNP_IDvariationvalidated
    1rs140104242R4QCluster,Frequency,1000Genome
    2rs351111V119ICluster,Frequency,1000Genome
    3rs144775105S125G1000Genome
    4rs113284122S131NCluster
    5rs150278723G149SFrequency
    6rs145794662R159CCluster
    7rs139778046H185LCluster,Frequency,1000Genome
    8rs150802678R249HCluster,Frequency,1000Genome


  • Cancer-related differential expression proteins derived from database dbDEPC:

    • NO.dbDEPC_IDchangeratiocancer namedesignsample_controlsample_casesamplepubmed
    1EXP00024Uterine CancerNormal vs. CancerNegative for Intraepithelial Lesions or Malignancy (NILM)High-Grade Squamous Intraepithelial Lesion(HSIL) tissue17902640  
    2EXP00252LeukemiaCancer vs. Cancer (subtype)M1, M4, M5 acute myeloid leukemia subtypesM2 and/or M3 acute myeloid leukemia subtypestissue15501966  



    [ continue search ]



    Dr. Jing Li's Group

    ©2015 Menghuan Zhang, Jing Li