ID you entered:  ENSP00000245907

Ensembl protein: ENSP00000245907   

          Protein sequence 
Name: C3
Description: complement component 3 [Source:HGNC Symbol;Acc:HGNC:1318]
Location:
            chr19 p13.3
Gene Ontology:
           Biological process 
           Molecular function 
           Cellular localization 
Interactions:   
          Interaction partner with cancer_related variations :  (  pvalue=0.00444452, hypergeometric test )
                 32 
          Interaction partner with cancer related differentially expressed proteins :  (  pvalue=0.000013999, hypergeometric test )
                 19 
                         

  • Cancer-related variations in CanProVar:
    • NO.csIDvariationchange conservation+Domaincancer namePubMeddata source++validated dbSNP*interface
    1cs88188S283F-2Head and Neck Cancer21984974   COSMIC
    2cs83480T654I-1Skin Cancer21984974   COSMIC
    3cs71882R764Q1Melanoma21499247   COSMIC
    4cs35994R834Q1PF00207  Breast Cancer21930502  21930507   BIOMARTCR2, CR1, CFH, VSIG4, CFB
    5cs15368V886I3Breast Cancer21930502  21930507   BIOMART
    6cs81733G1132R-2PF07678  Skin Cancer21984974   COSMICCR2, CR1, CFH, CFB, ITGAM
    7cs45035P1251L-3PF07678  Melanoma21499247   COSMICCR2, CR1, CFH, CFB, ITGAM
    8cs68095E1314K1Head and Neck Cancer21984974   COSMIC
    9cs22045T1341N0Ovarian Cancer21720365   COSMIC
    10cs23991E1487K1PF07677  Melanoma21499247   COSMICCFB, CFI

    +Conservation of amino acid substitutions are defined here according to the BLOSUM62 matrix, conservative changes were those having a positive or neutral sign in the matrix, whereas non-conservative changes were those having a negative value (Cargill, et al. 1999).
    ++Data sources:  HPI,  COSMIC,  OMIM,  TCGA,  BIOMART,  Greenman2007,  Sjoblom2006,  Ding2008
    *Cross-reference databases: dbSNP
    Interface information was collected from Wang 2012


  • Non-cancer specific variations derived from database dbSNP:

    • NO.dbSNP_IDvariationvalidated
    1rs138214338L9PFrequency
    2rs184455094H16Q1000Genome
    3rs2230199R102GCluster,Frequency,1000Genome
    4rs147859257K155QFrequency
    5rs1047286P314LCluster,Frequency,1000Genome
    6rs138945756L324F1000Genome
    7rs192989551D337E1000Genome
    8rs141737564I348VCluster,Frequency,1000Genome
    9rs143430438S452TFrequency
    10rs11569422E469DCluster,Frequency,1000Genome
    11rs149692538A482TCluster,Frequency
    12rs143887460G542DFrequency
    13rs140637006K607ECluster
    14rs146613648V619MFrequency
    15rs144432231I625FFrequency
    16rs140655115K633RFrequency
    17rs149850773G637RCluster
    18rs139893485Q653R1000Genome
    19rs112187261P663LCluster
    20rs112187261P663RCluster
    21rs117793540R735WCluster,Frequency,1000Genome
    22rs11569472R863KCluster,Frequency
    23rs149395057V886I1000Genome
    24rs75299866V944GCluster
    25rs146026441G1044RFrequency
    26rs11569534G1224DCluster,Frequency,1000Genome
    27rs112747284G1267CCluster
    28rs112747284G1267RCluster
    29rs112747284G1267SCluster
    30rs74722736V1365ICluster,1000Genome
    31rs11569541I1367TCluster,Frequency,1000Genome
    32rs139100972T1383NCluster
    33rs146172605I1385NFrequency
    34rs111228502Y1392CCluster
    35rs147116781D1440AFrequency
    36rs113742728D1457HCluster,Frequency,1000Genome
    37rs147883317A1460GFrequency
    38rs192424805V1463A1000Genome
    39rs140928439R1491WCluster,Frequency
    40rs142868256R1512HCluster
    41rs7256789Q1521RCluster
    42rs199911426R1532WCluster
    43rs149202905L1549MCluster,Frequency,1000Genome
    44rs144156850K1551NCluster,Frequency
    45rs139381845N1556SFrequency
    46rs2230210S1619RCluster,Frequency
    47rs34370481E1641GCluster


  • Cancer-related differential expression proteins derived from database dbDEPC:

    • NO.dbDEPC_IDchangeratiocancer namedesignsample_controlsample_casesamplepubmed
    1EXP00024Uterine CancerNormal vs. CancerNegative for Intraepithelial Lesions or Malignancy (NILM)High-Grade Squamous Intraepithelial Lesion(HSIL) tissue17902640  
    2EXP00094Breast CancerNormal vs. Cancerclinically normal peripheral tissuebreast cancer tissuestissue18257521  
    3EXP00286Ovarian CancerNormal vs. Cancerplasma of age-matched controlsplasma of ovarian cancer (OVC) patientstissue17137333  
    4EXP00286Ovarian CancerNormal vs. Cancerplasma of age-matched controlsplasma of ovarian cancer (OVC) patientstissue17137333  
    5EXP00327Uterine CancerNormal vs. CancerPlasma samples from patients with benign gynecological diseasePlasma samples from patients with cervical cancertissue19471570  
    6EXP000980.24breast ductal carcinomaNormal vs. Cancersurrounding histologically normal tissuesbreast tumor samplestissue18401453  
    7EXP002951.8Ovarian CancerNormal vs. Cancerserum of non-cancer controlsserum of ovarian carcinomatissue20162585  
    8EXP002952.1Ovarian CancerNormal vs. Cancerserum of non-cancer controlsserum of ovarian carcinomatissue20162585  
    9EXP002952.3Ovarian CancerNormal vs. Cancerserum of non-cancer controlsserum of ovarian carcinomatissue20162585  
    10EXP000023hepatitis C virusNormal vs. Canceradjacent non-neoplastic liver tissuesliver tumor tissuetissue18715028  
    11EXP003363Pancreatic CancerNormal vs. Cancerpooled pancreatic juices from 10 normal controlspancreatic cancerous juicetissue16739137  
    12EXP002635.4Brain CancerNormal vs. Cancercerebrospinal fluid (CSF) from non-neoplastic control patientscerebrospinal fluid (CSF) from patients with CNS lymphomatissue18056677  



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