ID you entered:  ENSP00000248244

Ensembl protein: ENSP00000248244   

          Protein sequence 
Name: TICAM1
Description: toll-like receptor adaptor molecule 1 [Source:HGNC Symbol;Acc:HGNC:18348]
Location:
            chr19 p13.3
Gene Ontology:
           Biological process 
           Molecular function 
           Cellular localization 
Interactions:   
          Interaction partner with cancer_related variations :  (  pvalue=0.0345598, hypergeometric test )
                 19 
          Interaction partner with cancer related differentially expressed proteins :    NA
                         

  • Cancer-related variations in CanProVar:
    • NO.csIDvariationchange conservation+Domaincancer namePubMeddata source++validated dbSNP*interface
    1cs3208M46I1Breast Cancer16959974   HPI, COSMIC, Sjoblom2006
    2cs36239S327F-2Skin Cancer21984974   COSMIC
    3cs88676F528L0Skin Cancer21984974   COSMIC
    4cs36174Q612K1Skin Cancer21984974   COSMIC
    5cs77365G675E-2Breast Cancer21930502  21930507   BIOMART

    +Conservation of amino acid substitutions are defined here according to the BLOSUM62 matrix, conservative changes were those having a positive or neutral sign in the matrix, whereas non-conservative changes were those having a negative value (Cargill, et al. 1999).
    ++Data sources:  HPI,  COSMIC,  OMIM,  TCGA,  BIOMART,  Greenman2007,  Sjoblom2006,  Ding2008
    *Cross-reference databases: dbSNP
    Interface information was collected from Wang 2012


  • Non-cancer specific variations derived from database dbSNP:

    • NO.dbSNP_IDvariationvalidated
    1rs114566317T4ICluster,Frequency,1000Genome
    2rs79591246T32ICluster,Frequency,1000Genome
    3rs11466719R75CCluster,Frequency,1000Genome
    4rs139070404R114Q1000Genome
    5rs145148929S160FFrequency
    6rs141394423R180CFrequency
    7rs146550489S186LFrequency
    8rs141739488D233H1000Genome
    9rs151272128G245SFrequency
    10rs11466721L275VHapMap
    11rs201243827S327P1000Genome
    12rs150740529A521TFrequency
    13rs142171170Q534KFrequency
    14rs143066432D557NFrequency
    15rs139939816R560W1000Genome
    16rs143679494A568TFrequency
    17rs146025102Y580C1000Genome
    18rs74359855G592RCluster,Frequency
    19rs113327885T623ICluster,Frequency,1000Genome
    20rs3177471P628SCluster
    21rs11466724A666TCluster,Frequency
    22rs200326236A703TCluster


  • Cancer-related differential expression proteins derived from database dbDEPC:


    • No entry in dbDEPC was found



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