ID you entered:  ENSP00000250896

Ensembl protein: ENSP00000250896   

          Protein sequence 
Name: MKNK2
Description: MAP kinase interacting serine/threonine kinase 2 [Source:HGNC Symbol;Acc:HGNC:7111]
Location:
            chr19 p13.3
Gene Ontology:
           Biological process 
           Molecular function 
           Cellular localization 
Interactions:   
          Interaction partner with cancer_related variations :  (  pvalue=0.230295, hypergeometric test )
                 7 
          Interaction partner with cancer related differentially expressed proteins :    NA
                         

  • Cancer-related variations in CanProVar:
    • NO.csIDvariationchange conservation+Domaincancer namePubMeddata source++validated dbSNP*interface
    1cs8964F149L0PF00069  PF07714  PF06293  Lung Cancer21930502  21930507  18948947   Ding2008, BIOMARTMAPK1
    2cs72819D228N1PF00069  PF07714  PF06293  Breast Cancer20668451   COSMICMAPK1
    3cs8963K390*-4Lung Cancer18948947   Ding2008, COSMIC

    +Conservation of amino acid substitutions are defined here according to the BLOSUM62 matrix, conservative changes were those having a positive or neutral sign in the matrix, whereas non-conservative changes were those having a negative value (Cargill, et al. 1999).
    ++Data sources:  HPI,  COSMIC,  OMIM,  TCGA,  BIOMART,  Greenman2007,  Sjoblom2006,  Ding2008
    *Cross-reference databases: dbSNP
    Interface information was collected from Wang 2012


  • Non-cancer specific variations derived from database dbSNP:

    • NO.dbSNP_IDvariationvalidated
    1rs3746101Q10KCluster,Frequency,1000Genome
    2rs144836311D32NFrequency
    3rs148831224V112ICluster
    4rs139155366R175Q1000Genome
    5rs201949864A360TCluster
    6rs142610986E416KFrequency
    7rs140693851G422SCluster,Frequency,1000Genome
    8rs34475638R428QCluster,Frequency,1000Genome
    9rs148261115A429SFrequency


  • Cancer-related differential expression proteins derived from database dbDEPC:


    • No entry in dbDEPC was found



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