ID you entered:  ENSP00000252674

Ensembl protein: ENSP00000252674   

          Protein sequence 
Name: MLLT1
Description: myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 [Source:HGNC Symbol;Acc:HGNC:7134]
Location:
            chr19 p13.3
Gene Ontology:
           Biological process 
           Molecular function 
           Cellular localization 
Interactions:   
          Interaction partner with cancer_related variations :  (  pvalue=0.0264117, hypergeometric test )
                 24 
          Interaction partner with cancer related differentially expressed proteins :    NA
                         

  • Cancer-related variations in CanProVar:
    • NO.csIDvariationchange conservation+Domaincancer namePubMeddata source++validated dbSNP*interface
    1cs36040C5Y-2Prostate Cancer23265383   COSMIC
    2cs85930L13Q-2Renal Cancer COSMIC
    3cs13455A17T0Uterine Cancer COSMIC
    4cs69784E26Q2Breast Cancer COSMIC
    5cs55567V34L1PF03366  Central Nervous System Neoplasms COSMIC
    6cs63957D57N1PF03366  Gastric Cancer COSMIC
    7cs45997E75Q2PF03366  Lung Cancer22980975   COSMIC
    8cs75117E94*-4PF03366  Liver Cancer COSMIC
    9cs15565C99F-2PF03366  Head and Neck Cancer23619168   COSMIC
    10cs25861C99Y-2PF03366  Urinary Bladder Cancer COSMIC
    11cs90322N111S1Intestines Cancer22810696   COSMIC
    12cs19732P112L-3Gastric Cancer22037554   COSMIC
    13cs96128V114M1Uterine Cancer COSMIC
    14cs96128V114M1Intestines Cancer COSMIC
    15cs30261V114L1Urinary Bladder Cancer COSMIC
    16cs61070N115S1Thyroid Carcinoma COSMIC
    17cs70820N115K0Uterine Cancer COSMIC
    18cs45290K121R2Urinary Bladder Cancer COSMIC
    19cs24424R132W-3Skin Cancer21984974   COSMIC
    20cs80966G140V-3Lung Cancer COSMIC
    21cs33809G180S0Liver Cancer23788652   COSMIC
    22cs53902R204W-3Intestines Cancer22895193   COSMIC
    23cs89020R206G-2Pancreatic Cancer COSMIC
    24cs78284R206H0Lung Cancer23033341   COSMIC
    25cs78284R206H0Thyroid Carcinoma COSMIC
    26cs80295R231W-3Uterine Cancer COSMIC
    27cs82468P277S-1Pancreatic Cancer COSMIC
    28cs51537S305L-2Uterine Cancer COSMIC
    29cs71846R309W-3Skin Cancer(Melanoma) COSMIC
    30cs73848R317C-3Uterine Cancer COSMIC
    31cs91260S322F-2Skin Cancer(Melanoma)23793026   COSMIC
    32cs78250A365S1Lung Cancer COSMIC
    33cs43302S366F-2Skin Cancer(Melanoma) COSMIC
    34cs57546S382G0Intestines Cancer COSMIC
    35cs73820S382I-2Intestines Cancer COSMIC
    36cs64864S383L-2Intestines Cancer COSMIC
    37cs74062G432W-2Esophageal Cancer COSMIC
    38cs64978D449N1Intestines Cancer22895193   COSMIC
    39cs74012L452Q-2Lung Cancer22975805   COSMIC
    40cs35769E477K1Intestines Cancer COSMIC
    41cs15636S480G0Liver Cancer COSMIC
    42cs61815R504L-2Prostate Cancer COSMIC
    43cs41610N520I-3Intestines Cancer23856246   COSMIC
    44cs73090V547M1Gastric Cancer COSMIC
    45cs84331E555G-2Ovarian Cancer COSMIC

    +Conservation of amino acid substitutions are defined here according to the BLOSUM62 matrix, conservative changes were those having a positive or neutral sign in the matrix, whereas non-conservative changes were those having a negative value (Cargill, et al. 1999).
    ++Data sources:  HPI,  COSMIC,  OMIM,  TCGA,  BIOMART,  Greenman2007,  Sjoblom2006,  Ding2008
    *Cross-reference databases: dbSNP
    Interface information was collected from Wang 2012


  • Non-cancer specific variations derived from database dbSNP:

    • NO.dbSNP_IDvariationvalidated
    1rs143656133S211NCluster,Frequency,1000Genome
    2rs146940691S230LFrequency
    3rs185592757A244V1000Genome
    4rs11880101A297TCluster,Frequency,1000Genome,HapMap
    5rs144530683G313AFrequency
    6rs144291468P329LCluster,Frequency
    7rs138601995S380TFrequency
    8rs142182747R504G1000Genome


  • Cancer-related differential expression proteins derived from database dbDEPC:


    • No entry in dbDEPC was found



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