CanProVar 2.0:Human Cancer Proteome Variation Database

ID you entered: ENSP00000262948

Ensembl protein: ENSP00000262948

Protein sequence

Name: MAP2K2

Description: mitogen-activated protein kinase kinase 2 [Source:HGNC Symbol;Acc:HGNC:6842]

Location:

chr19 p13.3

Gene Ontology:

Biological process

Molecular function

Cellular localization

Interactions:

Interaction partner with cancer_related variations :  ( pvalue=0.0482043, hypergeometric test )                 21

Interaction partner with cancer related differentially expressed proteins : NA

Cancer-related variations in CanProVar:

NO.	csID	variation	change conservation⁺	Domain	cancer name	PubMed	data source⁺⁺	validated dbSNP*	interface
1	cs93200	E27K	1		Skin Cancer(Melanoma)	22389471	COSMIC
2	cs65571	N33H	1		Renal Cancer		COSMIC
3	cs15902	K39M	-1		Ovarian Cancer	21720365	COSMIC
4	cs23408	L46F	0		Skin Cancer(Melanoma)		COSMIC
5	cs13504	Q50H	0		Breast Cancer		COSMIC
6	cs38911	R53Q	1		Uterine Cancer		COSMIC
7	cs98473	F57V	-1		Skin Cancer(Melanoma)		COSMIC
8	cs87048	F57L	0		Pancreatic Cancer		COSMIC
9	cs98473	F57V	-1		Gastric Cancer		COSMIC
10	cs87048	F57L	0		Lymphocytic Leukemia	23396385	COSMIC
11	cs75814	Q60P	-1		Lymphocytic Leukemia	23396385	COSMIC
12	cs75814	Q60P	-1		Skin Cancer(Melanoma)	24265154 24055054	COSMIC
13	cs94047	G65S	0		Uterine Cancer		COSMIC
14	cs21613	E66K	1		Intestines Cancer		COSMIC
15	cs65487	G83S	0	PF00069 PF07714	Breast Cancer		COSMIC		MAP2K2, RAB11A, MAPK3, MA
16	cs69741	S94L	-2	PF00069 PF07714	Pancreatic Cancer	24293293	COSMIC	rs202220799	MAP2K2, RAB11A, MAPK3, MA
17	cs78235	Q114H	0	PF00069 PF07714	Bone Neoplasms	23770606	COSMIC		MAP2K2, RAB11A, MAPK3, MA
18	cs65806	N126D	1	PF00069 PF07714	Lymphocytic Leukemia	24127483	COSMIC		MAP2K2, RAB11A, MAPK3, MA
19	cs18116	S127L	-2	PF00069 PF07714	Uterine Cancer		COSMIC		MAP2K2, RAB11A, MAPK3, MA
20	cs81991	P128L	-3	PF00069 PF07714	Skin Cancer(Melanoma)		COSMIC		MAP2K2, RAB11A, MAPK3, MA
21	cs27638	Y134C	-2	PF00069 PF07714	Head and Neck Cancer	23685749	COSMIC		MAP2K2, RAB11A, MAPK3, MA
22	cs53956	M150L	2	PF00069 PF07714	Lung Cancer		COSMIC		MAP2K2, RAB11A, MAPK3, MA
23	cs37822	Q157H	0	PF00069 PF07714	Ovarian Cancer		COSMIC		MAP2K2, RAB11A, MAPK3, MA
24	cs72776	V215E	-2	PF00069 PF07714	Intestines Cancer	22402123	COSMIC		MAP2K2, RAB11A, MAPK3, MA
25	cs26156	S248L	-2	PF00069 PF07714	Intestines Cancer		COSMIC		MAP2K2, RAB11A, MAPK3, MA
26	cs76180	H292R	0	PF00069	Gastric Cancer		COSMIC		MAP2K2, RAB11A, MAPK3, MA
27	cs49332	P298L	-3	PF00069	Lung Cancer	9121773	COSMIC		MAP2K2, RAB11A, MAPK3, MA
28	cs51620	P300L	-3	PF00069	Renal Cancer		COSMIC		MAP2K2, RAB11A, MAPK3, MA
29	cs71001	E328D	2	PF00069	Liver Cancer	23788652	COSMIC		MAP2K2, RAB11A, MAPK3, MA
30	cs34967	P331T	-1	PF00069	Esophageal Cancer		COSMIC		MAP2K2, RAB11A, MAPK3, MA
31	cs50076	D341H	-1	PF00069	Lung Cancer		COSMIC		MAP2K2, RAB11A, MAPK3, MA
32	cs35911	R388Q	1		Intestines Cancer	18186519	COSMIC

⁺Conservation of amino acid substitutions are defined here according to the BLOSUM62 matrix, conservative changes were those having a positive or neutral sign in the matrix, whereas non-conservative changes were those having a negative value (Cargill, et al. 1999).
⁺⁺Data sources: HPI, COSMIC, OMIM, TCGA, BIOMART, Greenman2007, Sjoblom2006, Ding2008
*Cross-reference databases: dbSNP
Interface information was collected from Wang 2012

Non-cancer specific variations derived from database dbSNP:

NO.	dbSNP_ID	variation	validated
1	rs187018595	E73Q	1000Genome
2	rs202220799	S94L	Cluster
3	rs138873805	V262I	Frequency
4	rs142307980	P282S	Frequency
5	rs185999703	V283L	1000Genome
6	rs150369301	D285N	Cluster,1000Genome
7	rs151133017	R313Q	Cluster
8	rs144383241	R388W	Frequency
9	rs117945277	T396M	1000Genome

Cancer-related differential expression proteins derived from database dbDEPC:

No entry in dbDEPC was found

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