ID you entered:  ENSP00000262958

Ensembl protein: ENSP00000262958   

          Protein sequence 
Name: GNA15
Description: guanine nucleotide binding protein (G protein), alpha 15 (Gq class) [Source:HGNC Symbol;Acc:HGNC:4383]
Location:
            chr19 p13.3
Gene Ontology:
           Biological process 
           Molecular function 
           Cellular localization 
Interactions:   
          Interaction partner with cancer_related variations :  (  pvalue=0.2544, hypergeometric test )
                 6 
          Interaction partner with cancer related differentially expressed proteins :  (  pvalue=0.283431, hypergeometric test )
                 1 
                         

  • Cancer-related variations in CanProVar:
    • NO.csIDvariationchange conservation+Domaincancer namePubMeddata source++validated dbSNP*interface
    1cs56306E173K1PF00503  Melanoma21499247   COSMIC
    2cs58659P301S-1PF00503  Melanoma20424519   COSMIC
    3cs94554E328K1PF00503  Head and Neck Cancer21798893   COSMIC
    4cs56029R366C-3PF00503  Melanoma21499247   COSMIC

    +Conservation of amino acid substitutions are defined here according to the BLOSUM62 matrix, conservative changes were those having a positive or neutral sign in the matrix, whereas non-conservative changes were those having a negative value (Cargill, et al. 1999).
    ++Data sources:  HPI,  COSMIC,  OMIM,  TCGA,  BIOMART,  Greenman2007,  Sjoblom2006,  Ding2008
    *Cross-reference databases: dbSNP
    Interface information was collected from Wang 2012


  • Non-cancer specific variations derived from database dbSNP:

    • NO.dbSNP_IDvariationvalidated
    1rs75723333R3HCluster,1000Genome
    2rs139115108S114NCluster,Frequency,1000Genome
    3rs149877401M117I1000Genome
    4rs76346810E168KCluster
    5rs199847220R169CCluster
    6rs143953630V182MCluster
    7rs2230330M187ICluster,Frequency,1000Genome
    8rs151214875V199MFrequency
    9rs143247880E283GFrequency


  • Cancer-related differential expression proteins derived from database dbDEPC:

    • NO.dbDEPC_IDchangeratiocancer namedesignsample_controlsample_casesamplepubmed
    1EXP002250.02Breast CancerNormal vs. Cancer16N (normal) cellsNT cells (the primary tumor cells)cell line20198662  



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