CanProVar 2.0:Human Cancer Proteome Variation Database

ID you entered: ENSP00000262965

Ensembl protein: ENSP00000262965

Protein sequence

Name: TCF3

Description: transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:11633]

Location:

chr19 p13.3

Gene Ontology:

Biological process

Molecular function

Cellular localization

Interactions:

Interaction partner with cancer_related variations :  ( pvalue=0.00384976, hypergeometric test )                 45

Interaction partner with cancer related differentially expressed proteins : NA

Cancer-related variations in CanProVar:

NO.	csID	variation	change conservation⁺	Domain	cancer name	PubMed	data source⁺⁺	interface
1	cs4817	A8V	0		Intestines Cancer	16959974	COSMIC, Sjoblom2006
2	cs4817	A8V	0		Colorectal Cancer	16959974	HPI
3	cs54470	A8S	1		Intestines Cancer		COSMIC
4	cs74421	V10L	1		Lung Cancer	20668451	COSMIC
5	cs46518	V10A	0		Renal Cancer		COSMIC
6	cs90809	L20R	-2		Ovarian Cancer		COSMIC
7	cs51969	A41T	0		Liver Cancer		COSMIC
8	cs22668	R105Q	1		Thyroid Carcinoma		COSMIC
9	cs39243	A107T	0		Uterine Cancer		COSMIC
10	cs39243	A107T	0		Gastric Cancer		COSMIC
11	cs58492	L120P	-3		Liver Cancer		COSMIC
12	cs69597	S134N	1		Renal Cancer		COSMIC
13	cs66980	S157Y	-2		Intestines Cancer		COSMIC
14	cs26012	R159W	-3		Lung Cancer		COSMIC
15	cs87843	R160I	-3		Intestines Cancer		COSMIC
16	cs91814	T168M	-1		Central Nervous System Neoplasms		COSMIC
17	cs91814	T168M	-1		Intestines Cancer		COSMIC
18	cs27098	P201S	-1		Skin Cancer(Melanoma)		COSMIC
19	cs87982	D218E	2		Breast Cancer	20668451	COSMIC
20	cs40937	P255Q	-1		Lymphocytic Leukemia	23415222	COSMIC
21	cs20490	G298*	-4		Thyroid Carcinoma		COSMIC
22	cs53935	S359F	-2		Liver Cancer		COSMIC
23	cs76254	R371*	-4		Intestines Cancer		COSMIC
24	cs11627	S391T	1		Central Nervous System Neoplasms	23917401	COSMIC
25	cs13502	G431S	0		Lung Cancer	20505728	COSMIC
26	cs76287	G470C	-3		Lung Cancer		COSMIC
27	cs23925	S476C	-1		Lung Cancer		COSMIC
28	cs42422	G486W	-2		Thyroid Carcinoma		COSMIC
29	cs47493	T491M	-1		Skin Cancer	21984974	COSMIC
30	cs12708	K518E	1		Intestines Cancer		COSMIC
31	cs20529	A544V	0		Intestines Cancer		COSMIC
32	cs95496	E545K	1		Lung Cancer	20668451	COSMIC
33	cs68041	R557W	-3	PF00010	Intestines Cancer		COSMIC	TCF4, TAL1, MYF5, MYF6, T
34	cs21950	R559W	-3	PF00010	Lymphocytic Leukemia	23856246	COSMIC	TCF4, TAL1, MYF5, MYF6, T
35	cs21950	R559W	-3	PF00010	Intestines Cancer	22895193	COSMIC	TCF4, TAL1, MYF5, MYF6, T
36	cs33279	R561W	-3	PF00010	Breast Cancer		COSMIC	TCF4, TAL1, MYF5, MYF6, T
37	cs34231	R563C	-3	PF00010	Gastric Cancer		COSMIC	TCF4, TAL1, MYF5, MYF6, T
38	cs71166	E567K	1	PF00010	Gastric Cancer		COSMIC	TCF4, TAL1, MYF5, MYF6, T
39	cs71166	E567K	1	PF00010	Uterine Cancer		COSMIC	TCF4, TAL1, MYF5, MYF6, T
40	cs26851	L572M	2	PF00010	Uterine Cancer		COSMIC	TCF4, TAL1, MYF5, MYF6, T
41	cs38216	R574H	0	PF00010	Gastric Cancer		COSMIC	TCF4, TAL1, MYF5, MYF6, T
42	cs56923	V598I	3	PF00010	Lymphocytic Leukemia	23856246	COSMIC	TCF4, TAL1, MYF5, MYF6, T
43	cs53165	R607*	-4		Uterine Cancer		COSMIC
44	cs18764	R607Q	1		Lymphocytic Leukemia		COSMIC
45	cs45987	R609Q	1		Lymphocytic Leukemia		COSMIC
46	cs93842	R621*	-4		Uterine Cancer		COSMIC
47	cs66723	P633L	-3		Ovarian Cancer	20668451	COSMIC
48	cs10874	P640L	-3		Skin Cancer(Melanoma)		COSMIC

⁺Conservation of amino acid substitutions are defined here according to the BLOSUM62 matrix, conservative changes were those having a positive or neutral sign in the matrix, whereas non-conservative changes were those having a negative value (Cargill, et al. 1999).
⁺⁺Data sources: HPI, COSMIC, OMIM, TCGA, BIOMART, Greenman2007, Sjoblom2006, Ding2008
*Cross-reference databases: dbSNP
Interface information was collected from Wang 2012

Non-cancer specific variations derived from database dbSNP:

NO.	dbSNP_ID	variation	validated
1	rs147133056	A8S	Cluster,Frequency,1000Genome
2	rs143787476	D63N	Frequency
3	rs41275842	K101R	Cluster,Frequency,1000Genome
4	rs113419714	A115T	Cluster,Frequency
5	rs35936626	G119S	Cluster,Frequency,1000Genome
6	rs35354874	L120P	Cluster,Frequency,1000Genome
7	rs11879402	T198A	HapMap,1000Genome,Cluster,Frequency
8	rs138005323	A203T	Cluster
9	rs138005323	A203P	Cluster
10	rs145095368	T300A	Frequency
11	rs148928381	G362D	Cluster,Frequency,1000Genome
12	rs117006898	G385D	Frequency,1000Genome
13	rs77342409	I401T	Cluster
14	rs201296678	R405H	Cluster
15	rs76812041	T411P	Cluster
16	rs76459051	A424V	Cluster,Frequency,1000Genome
17	rs1052692	G431S	Cluster,Frequency,1000Genome
18	rs200168957	G451S	Cluster
19	rs2074888	A492V	Cluster,Frequency,1000Genome
20	rs182482393	R499W	1000Genome
21	rs149277795	R499L	Frequency
22	rs190995532	K502E	1000Genome
23	rs139492270	T508M	Cluster
24	rs115383004	H513Q	Cluster,Frequency,1000Genome
25	rs145878545	R525W	Frequency
26	rs141432924	R527Q	Frequency
27	rs1052793	P585R	HapMap

Cancer-related differential expression proteins derived from database dbDEPC:

No entry in dbDEPC was found

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