ID you entered:  ENSP00000263620

Ensembl protein: ENSP00000263620   

          Protein sequence 
Name: ARID3A
Description: AT rich interactive domain 3A (BRIGHT-like) [Source:HGNC Symbol;Acc:HGNC:3031]
Location:
            chr19 p13.3
Gene Ontology:
           Biological process 
           Molecular function 
           Cellular localization 
Interactions:   
          Interaction partner with cancer_related variations :  (  pvalue=0.0948801, hypergeometric test )
                 11 
          Interaction partner with cancer related differentially expressed proteins :  (  pvalue=0.273778, hypergeometric test )
                 2 
                         

  • Cancer-related variations in CanProVar:
    • NO.csIDvariationchange conservation+Domaincancer namePubMeddata source++validated dbSNP*interface
    1cs37078S357F-2Breast Cancer21930502  21930507   BIOMART
    2cs33154Y530D-3Ovarian Cancer21720365   COSMIC

    +Conservation of amino acid substitutions are defined here according to the BLOSUM62 matrix, conservative changes were those having a positive or neutral sign in the matrix, whereas non-conservative changes were those having a negative value (Cargill, et al. 1999).
    ++Data sources:  HPI,  COSMIC,  OMIM,  TCGA,  BIOMART,  Greenman2007,  Sjoblom2006,  Ding2008
    *Cross-reference databases: dbSNP
    Interface information was collected from Wang 2012


  • Non-cancer specific variations derived from database dbSNP:

    • NO.dbSNP_IDvariationvalidated
    1rs116393241G79SFrequency,1000Genome
    2rs187709308D120N1000Genome
    3rs71335278E148KCluster
    4rs71335278E148QCluster
    5rs141023843E152KFrequency
    6rs61735587A171TCluster,Frequency,1000Genome
    7rs145850291A404VCluster,Frequency,1000Genome
    8rs143073569R412CFrequency
    9rs140675218R494QCluster,Frequency,1000Genome
    10rs143256319R503H1000Genome
    11rs1051505G556SHapMap,1000Genome,Cluster,Frequency
    12rs143689585R564QFrequency


  • Cancer-related differential expression proteins derived from database dbDEPC:

    • NO.dbDEPC_IDchangeratiocancer namedesignsample_controlsample_casesamplepubmed
    1EXP000042.3Hepatocellular CarcinomaNormal vs. CancerHL-7702 normal cellsAFP-deficient SK-HEP-1 liver cancer cellscell line18646787  
    2EXP000039.8Hepatocellular CarcinomaNormal vs. CancerHL-7702 normal cellsAFP-producing HepG2 liver cancer cellscell line18646787  



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