ID you entered:  ENSP00000263621

Ensembl protein: ENSP00000263621   

          Protein sequence 
Name: ELANE
Description: elastase, neutrophil expressed [Source:HGNC Symbol;Acc:HGNC:3309]
Location:
            chr19 p13.3
Gene Ontology:
           Biological process 
           Molecular function 
           Cellular localization 
Interactions:   
          Interaction partner with cancer_related variations :  (  pvalue=0.0275149, hypergeometric test )
                 20 
          Interaction partner with cancer related differentially expressed proteins :  (  pvalue=0.000101203, hypergeometric test )
                 13 
                         

  • Cancer-related variations in CanProVar:
    • NO.csIDvariationchange conservation+Domaincancer namePubMeddata source++validated dbSNP*interface
    1cs82889R5H0Pancreatic Cancer COSMIC

    +Conservation of amino acid substitutions are defined here according to the BLOSUM62 matrix, conservative changes were those having a positive or neutral sign in the matrix, whereas non-conservative changes were those having a negative value (Cargill, et al. 1999).
    ++Data sources:  HPI,  COSMIC,  OMIM,  TCGA,  BIOMART,  Greenman2007,  Sjoblom2006,  Ding2008
    *Cross-reference databases: dbSNP
    Interface information was collected from Wang 2012


  • Non-cancer specific variations derived from database dbSNP:

    • NO.dbSNP_IDvariationvalidated
    1rs201792358R35*Cluster
    2rs28931611C71RCluster
    3rs137854449V101LCluster
    4rs137854449V101MCluster
    5rs200993994R143HCluster
    6rs112990855G164RCluster
    7rs193141883T175M1000Genome
    8rs140880838G210RFrequency
    9rs17216656V219ICluster,Frequency,1000Genome
    10rs137854445R220QCluster
    11rs137854445R220PCluster
    12rs17216663P257LCluster,Frequency
    13rs202234596R258QCluster
    14rs143579306P260TFrequency
    15rs138211132P262SFrequency
    16rs17216670P262LCluster,Frequency,1000Genome


  • Cancer-related differential expression proteins derived from database dbDEPC:

    • NO.dbDEPC_IDchangeratiocancer namedesignsample_controlsample_casesamplepubmed
    1EXP00024Uterine CancerNormal vs. CancerNegative for Intraepithelial Lesions or Malignancy (NILM)High-Grade Squamous Intraepithelial Lesion(HSIL) tissue17902640  



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