ID you entered:  ENSP00000269886

Ensembl protein: ENSP00000269886   

          Protein sequence 
Name: SH3GL1
Description: SH3-domain GRB2-like 1 [Source:HGNC Symbol;Acc:HGNC:10830]
Location:
            chr19 p13.3
Gene Ontology:
           Biological process 
           Molecular function 
           Cellular localization 
Interactions:   
          Interaction partner with cancer_related variations :  (  pvalue=0.0965681, hypergeometric test )
                 20 
          Interaction partner with cancer related differentially expressed proteins :    NA
                         

  • Cancer-related variations in CanProVar:
    • NO.csIDvariationchange conservation+Domaincancer namePubMeddata source++validated dbSNP*interface
    1cs83323G5R-2Skin Cancer(Melanoma)23856246   COSMIC
    2cs11786G23V-3PF03114  Gastric Cancer COSMICSH3GL1, SH3GL3
    3cs93365A24S1PF03114  Urinary Bladder Cancer COSMICSH3GL1, SH3GL3
    4cs90582E25*-4PF03114  Lung Cancer COSMICSH3GL1, SH3GL3
    5cs11978E25K1PF03114  Intestines Cancer COSMICSH3GL1, SH3GL3
    6cs92516A46V0PF03114  Prostate Cancer COSMICSH3GL1, SH3GL3
    7cs39568T54I-1PF03114  Intestines Cancer COSMICSH3GL1, SH3GL3
    8cs67748S64L-2PF03114  Esophageal Cancer COSMICSH3GL1, SH3GL3
    9cs14211R65Q1PF03114  Intestines Cancer22895193   COSMICSH3GL1, SH3GL3
    10cs32492K67M-1PF03114  Uterine Cancer COSMICSH3GL1, SH3GL3
    11cs35723K76N0PF03114  Breast Cancer COSMICSH3GL1, SH3GL3
    12cs69580S89L-2PF03114  Skin Cancer(Melanoma) COSMICSH3GL1, SH3GL3
    13cs44066E103G-2PF03114  Liver Cancer COSMICSH3GL1, SH3GL3
    14cs45634M121I1PF03114  PF10455  Skin Cancer(Melanoma) COSMICSH3GL1, SH3GL3
    15cs83354K122*-4PF03114  PF10455  Lung Cancer22980975   COSMICSH3GL1, SH3GL3
    16cs48369L143I2PF03114  PF10455  Intestines Cancer22895193   COSMICSH3GL1, SH3GL3
    17cs21178E162K1PF03114  PF10455  Urinary Bladder Cancer COSMICSH3GL1, SH3GL3
    18cs24193R164H0PF03114  PF10455  Gastric Cancer COSMICSH3GL1, SH3GL3
    19cs14449Y170C-2PF03114  PF10455  Gastric Cancer COSMICSH3GL1, SH3GL3
    20cs27879E181K1PF03114  PF10455  Skin Cancer(Melanoma) COSMICSH3GL1, SH3GL3
    21cs44944R184C-3PF03114  PF10455  Renal Cancer22385958   COSMICSH3GL1, SH3GL3
    22cs11167E188D2PF03114  PF10455  Urinary Bladder Cancer COSMICSH3GL1, SH3GL3
    23cs85398A217T0PF03114  PF10455  Uterine Cancer COSMICSH3GL1, SH3GL3
    24cs92112A221T0PF03114  PF10455  Ovarian Cancer COSMICSH3GL1, SH3GL3
    25cs65833Y225D-3PF03114  PF10455  Ovarian Cancer20668451   COSMICSH3GL1, SH3GL3
    26cs96636Y225C-2PF03114  PF10455  Renal Cancer COSMICSH3GL1, SH3GL3
    27cs17559E254K1Uterine Cancer COSMIC
    28cs57197F263V-1Liver Cancer COSMIC
    29cs25645E269Q2Intestines Cancer COSMIC
    30cs30550S271F-2Urinary Bladder Cancer COSMIC
    31cs39445C277Y-2Uterine Cancer COSMIC
    32cs78963R290*-4Ovarian Cancer21720365   COSMIC
    33cs55011R301W-3Intestines Cancer COSMICrs150284370
    34cs87883P304S-1Lung Cancer23033341   COSMIC
    35cs59889P309L-3Gastric Cancer COSMIC
    36cs56683P309S-1Ovarian Cancer23780408   COSMIC
    37cs14885E320K1PF07653  PF00018  Gastric Cancer COSMICSH2D4A, DNM1, SH3GL1, SH3
    38cs77125I333M1PF07653  PF00018  Lung Cancer COSMICSH2D4A, DNM1, SH3GL1, SH3

    +Conservation of amino acid substitutions are defined here according to the BLOSUM62 matrix, conservative changes were those having a positive or neutral sign in the matrix, whereas non-conservative changes were those having a negative value (Cargill, et al. 1999).
    ++Data sources:  HPI,  COSMIC,  OMIM,  TCGA,  BIOMART,  Greenman2007,  Sjoblom2006,  Ding2008
    *Cross-reference databases: dbSNP
    Interface information was collected from Wang 2012


  • Non-cancer specific variations derived from database dbSNP:

    • NO.dbSNP_IDvariationvalidated
    1rs142802456L71F1000Genome
    2rs139264612R242CFrequency
    3rs138726702A284T1000Genome
    4rs146037902I296TFrequency
    5rs149527990R297WCluster
    6rs150284370R301WFrequency
    7rs138715687E318QCluster
    8rs150388848G350SCluster,Frequency,1000Genome


  • Cancer-related differential expression proteins derived from database dbDEPC:


    • No entry in dbDEPC was found



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