ID you entered:  ENSP00000269907

Ensembl protein: ENSP00000269907   

          Protein sequence 
Name: PTPRS
Description: protein tyrosine phosphatase, receptor type, S [Source:HGNC Symbol;Acc:HGNC:9681]
Location:
            chr19 p13.3
Gene Ontology:
           Biological process 
           Molecular function 
           Cellular localization 
Interactions:   
          Interaction partner with cancer_related variations :  (  pvalue=0.14734, hypergeometric test )
                 19 
          Interaction partner with cancer related differentially expressed proteins :  (  pvalue=0.196994, hypergeometric test )
                 5 
                         

  • Cancer-related variations in CanProVar:
    • NO.csIDvariationchange conservation+Domaincancer namePubMeddata source++validated dbSNP*interface
    1cs3228T974M-1PF00041  Intestines Cancer21930502  16959974  21930507   Sjoblom2006
    2cs3228T974M-1PF00041  Colorectal Cancer21930502  21930507   BIOMART

    +Conservation of amino acid substitutions are defined here according to the BLOSUM62 matrix, conservative changes were those having a positive or neutral sign in the matrix, whereas non-conservative changes were those having a negative value (Cargill, et al. 1999).
    ++Data sources:  HPI,  COSMIC,  OMIM,  TCGA,  BIOMART,  Greenman2007,  Sjoblom2006,  Ding2008
    *Cross-reference databases: dbSNP
    Interface information was collected from Wang 2012


  • Non-cancer specific variations derived from database dbSNP:

    • NO.dbSNP_IDvariationvalidated
    1rs61729776C27YCluster,Frequency,1000Genome
    2rs115231439K40R1000Genome
    3rs146675930T80MCluster,Frequency
    4rs114080870V113ACluster,Frequency,1000Genome
    5rs139336866N136SCluster
    6rs79388082S348FCluster
    7rs79960932S348TCluster
    8rs115982731T372I1000Genome
    9rs73545312V449ICluster,1000Genome
    10rs144686472E482KCluster,1000Genome
    11rs145504993P535LFrequency
    12rs185326821P562L1000Genome
    13rs138765579A578TCluster
    14rs141070507R813C1000Genome
    15rs199604489R829LCluster
    16rs115276698E831A1000Genome
    17rs151114416R850C1000Genome
    18rs200860780A885VCluster
    19rs61729778R907CFrequency,1000Genome
    20rs201357930A969TCluster
    21rs2230610A969V1000Genome
    22rs3202678F1075LHapMap
    23rs201447856T1090MCluster
    24rs140049694G1114SFrequency
    25rs115469963R1172HCluster,1000Genome
    26rs142918634R1184QCluster,Frequency,1000Genome
    27rs115469963R1190HCluster,1000Genome
    28rs114904537H1199N1000Genome
    29rs202091186R1219HCluster
    30rs116545788V1227MCluster,Frequency,1000Genome
    31rs114166264R1346QCluster,Frequency,1000Genome
    32rs114545401A1389TCluster,1000Genome
    33rs190342971P1399L1000Genome
    34rs192807174V1414M1000Genome
    35rs4807697C1419RCluster,Frequency,1000Genome,HapMap
    36rs189135288A1422T1000Genome
    37rs116660613P1429LCluster,1000Genome
    38rs116515629V1450I1000Genome
    39rs147152459T1472MCluster
    40rs116099658G1476SCluster,1000Genome
    41rs182037655T1515M1000Genome
    42rs142364974R1570WCluster,Frequency
    43rs148739536R1570QFrequency
    44rs61729772G1636CFrequency
    45rs61729772G1641CFrequency
    46rs1064301N1663KHapMap
    47rs1064301N1667KHapMap
    48rs116345982V1738MCluster,1000Genome
    49rs148478353S1814LCluster,Frequency,1000Genome
    50rs142977438V1851ICluster,Frequency,1000Genome
    51rs115470613T1873M1000Genome


  • Cancer-related differential expression proteins derived from database dbDEPC:


    • No entry in dbDEPC was found



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