ID you entered:  ENSP00000301264

Ensembl protein: ENSP00000301264   

          Protein sequence 
Name: DAPK3
Description: death-associated protein kinase 3 [Source:HGNC Symbol;Acc:HGNC:2676]
Location:
            chr19 p13.3
Gene Ontology:
           Biological process 
           Molecular function 
           Cellular localization 
Interactions:   
          Interaction partner with cancer_related variations :  (  pvalue=0.0580027, hypergeometric test )
                 13 
          Interaction partner with cancer related differentially expressed proteins :  (  pvalue=0.100604, hypergeometric test )
                 5 
                         

  • Cancer-related variations in CanProVar:
    • NO.csIDvariationchange conservation+Domaincancer namePubMeddata source++validated dbSNP*interface
    1cs549T112M-1PF00069  PF06293  PF07714  Intestines Cancer21487036  18428421  17344846   Greenman2007
    2cs549T112M-1PF00069  PF06293  PF07714  Colorectal Cancer21487036   HPI
    3cs551D161N1PF00069  PF06293  PF07714  Ovarian Cancer21487036  18428421  17344846   HPI, Greenman2007
    4cs550P216S-1PF00069  PF07714  Lung Cancer21487036  18428421  21487036  17344846   HPI, Greenman2007

    +Conservation of amino acid substitutions are defined here according to the BLOSUM62 matrix, conservative changes were those having a positive or neutral sign in the matrix, whereas non-conservative changes were those having a negative value (Cargill, et al. 1999).
    ++Data sources:  HPI,  COSMIC,  OMIM,  TCGA,  BIOMART,  Greenman2007,  Sjoblom2006,  Ding2008
    *Cross-reference databases: dbSNP
    Interface information was collected from Wang 2012


  • Non-cancer specific variations derived from database dbSNP:

    • NO.dbSNP_IDvariationvalidated
    1rs139511601R28WCluster
    2rs199986718R31WCluster
    3rs150676155E62QFrequency
    4rs141934386H73YFrequency
    5rs200475430S97CCluster
    6rs201446546K327ECluster
    7rs181345641A358T1000Genome
    8rs147011394S373NFrequency
    9rs201287470R382WCluster
    10rs200352688E389KCluster


  • Cancer-related differential expression proteins derived from database dbDEPC:

    • NO.dbDEPC_IDchangeratiocancer namedesignsample_controlsample_casesamplepubmed
    1EXP000150.31Gastric CancerMetastasisthe noninvasive gastric cancer SC-M1 cellthe metastatic gastric cancer TMC-1 cellscell line17022644  
    2EXP001860.31Gastric CancerMetastasisthe noninvasive gastric cancer SC-M1 cell(a well-established human gastric carcinoma cell line, originally cultured from a poorly differentiated adenocarcinoma that invaded through the stomach wall but showed no metastasis to lymph nodes or adjacent organs)the metastatic gastric cancer TMC-1 cells(derived from the lymph node of an individual with a moderately differentiated adenocarcinoma of the stomach and exhibited highly tumorigenic features)cell line17022644  



    [ continue search ]



    Dr. Jing Li's Group

    ©2015 Menghuan Zhang, Jing Li